Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development

The transient receptor potential vanilloid 1 (TRPV1) ion channel plays an important role in the peripheral nociceptive pathway. TRPV1 is a polymodal receptor that can be activated by multiple types of ligands and painful stimuli, such as noxious heat and protons, and contributes to various acute and chronic pain conditions. Therefore, TRPV1 is emerging as a novel therapeutic target for the treatment of various pain conditions. Notably, various peptides isolated from venomous animals potently and selectively control the activation and inhibition of TRPV1 by binding to its outer pore region. This review will focus on the mechanisms by which venom-derived peptides interact with this portion of TRPV1 to control receptor functions and how these mechanisms can drive the development of new types of analgesics.     

Ag/LaNixCo1-xO3触点材料的制备及电接触性能研究

本文运用溶胶-凝胶燃烧法合成了双钙钛矿型LaNixCo1-xO3(LNCO)纳米材料,利用粉末冶金和热挤压技术制备了相应的Ag/LNCO触点材料及元件样品。重点考察了不同Ni、Co含量对Ag/LNCO触点材料微观结构、物相组成、物理性能、力学性能及电寿命服役能力的影响,对其电弧侵蚀失效行为进行了研究,并与SnO2粉体增强Ag基触点材料进行对比。结果表明:溶胶凝胶法合成的LNCO纳米颗粒粒径为20-30 nm,经粉末冶金工艺制备的Ag/LaNi0.5Co0.5O3触点材料电学性能和电寿命都优于Ag/SnO2触点材料,其电阻率低至2.10 μΩ?cm,电寿命性能达到51287次。表明Ag/LaNi0.5Co0.5O3触点材料性能较佳,是一种可以取代Ag/CdO的新型触点材料。     

Effect of carrier screening on ZnO-based resistive switching memory devices

The carrier screening effect occurs commonly in dielectric materials. It reduces the electric potential gradient, thus negatively affecting the functionality of resistive random access memory (RRAM) devices. An Au/ZnO film/Al-doped ZnO device fabricated in this work exhibited no resistive switching (RS), which was attributed to the carrier screening effect. Therefore, annealing was used for alleviating the screening effect, significantly enhancing the RS property. In addition, different on/off ratios were obtained for various bias values, and the screening effect was accounted for by investigating electron transport mechanisms. Furthermore, different annealing temperatures were employed to modulate the free carrier concentration in ZnO films to alleviate the screening effect. The maximal on/off ratio reached 10⁵ at an annealing temperature of 600 °C, yielding the lowest number of free carriers and the weakest screening effect in ZnO films. This work investigates the screening effect in RS devices. The screening effect not only modulates the characteristics of memory devices but also provides insight into the mechanism of RS in these devices.

Open image in new window

     

Characterization of Inhibitory Capability on Hyperpolarization-Activated Cation Current Caused by Lutein (β,ε-Carotene-3,3′-Diol), a Dietary Xanthophyll Carotenoid

Lutein (β,ε-carotene-3,3′-diol), a xanthophyll carotenoid, is found in high concentrations in the macula of the human retina. It has been recognized to exert potential effectiveness in antioxidative and anti-inflammatory properties. However, whether and how its modifications on varying types of plasmalemmal ionic currents occur in electrically excitable cells remain incompletely answered. The current hypothesis is that lutein produces any direct adjustments on ionic currents (e.g., hyperpolarization-activated cation current, I_h [or funny current, I_f]). In the present study, GH₃-cell exposure to lutein resulted in a time-, state- and concentration-dependent reduction in I_h amplitude with an IC₅₀ value of 4.1 μM. There was a hyperpolarizing shift along the voltage axis in the steady-state activation curve of I_h in the presence of this compound, despite being void of changes in the gating charge of the curve. Under continued exposure to lutein (3 μM), further addition of oxaliplatin (10 μM) or ivabradine (3 μM) could be effective at either reversing or further decreasing lutein-induced suppression of hyperpolarization-evoked I_h, respectively. The voltage-dependent anti-clockwise hysteresis of I_h responding to long-lasting inverted isosceles-triangular ramp concentration-dependently became diminished by adding this compound. However, the addition of 10 μM lutein caused a mild but significant suppression in the amplitude of erg-mediated or A-type K⁺ currents. Under current-clamp potential recordings, the sag potential evoked by long-lasting hyperpolarizing current stimulus was reduced under cell exposure to lutein. Altogether, findings from the current observations enabled us to reflect that during cell exposure to lutein used at pharmacologically achievable concentrations, lutein-perturbed inhibition of I_h would be an ionic mechanism underlying its changes in membrane excitability.     

土石坝防渗墙体与坝体间摩擦接触单元理论研究

土石坝中常存在变形性能相差很大的两种材料相接触的情况,如混凝土防渗墙与两侧坝体的接触等。在一定的受力情况下,有可能在接触面上发生错动或开裂。为反映这种情况,可在接触面上设置摩擦接触单元。     

基于脑机接口集成控制系统

针对目前大部分关于脑-机接口系统控制的目标都是单一对象（如：电灯、电视等）,利用界面分层方法实现了脑-机接口家电集成控制。此系统可以有效控制电灯、电视等设备并且可以进行文字输入操作,能辅助神经功能障碍患者（如瘫痪病人）,提高其自理能力和生活水平,也可以为特殊环境下（如太空环境）的健康者提供一种辅助控制方法。     

三角网格表面等残留高度刀轨生成算法

针对截平面法规划的三角网格表面的刀轨长度较长、加工表面残留高度不均匀的问题,提出一种基于改进截平面法的等残留高度刀轨生成算法.首先在估算刀触点轨迹线垂直方向曲率半径的基础上,计算刀触点轨迹投影线并对其进行修正,去除其中冗余的投影点;然后由修正后的刀触点轨迹投影线构造驱动表面,利用驱动表面和网格表面迭代计算刀触点轨迹线;最后由刀触点轨迹线计算无干涉刀轨.与截平面法生成的刀轨进行比较分析的结果表明,文中算法生成的刀轨长度较小且获得的残留高度保持均匀,适合于三角网格表面表示的复杂表面的精加工.     

利用动态规划和电势理论规划UAV三维航迹

用改进的电势理论规划无人机的三维航迹。充分考虑了地形威胁、火力及雷达威胁同时存在的情况,并对它们的权重对航迹规划的影响进行了研究。通过限制航线到包含任务起止点直线的距离,不但克服了电势法无法收敛目标点的问题,而且可以缩短飞行航程;研究惩罚函数中各因素不同权重对飞行航线的影响,选择出最优权重系数;通过仿真试验可知,该方法能够成功地为无人机规划出安全的飞行路径。     

微系统技术（连载六）─性能与测试

简要介绍了利用新型干涉仪测量微机械零件表面粗糙度的原理和方法，加载结构动摩擦系数测量，微系统器件残余应力分析和半导体器件表面电位测量。     

500kV断路器无保护跳闸故障分析

贵州省500kV六盘水变电站500kV5032断路器发生一起无保护跳闸事故,重点分析事故的动作行为及发生的原因,阐述了断路器辅助接点绝缘降低造成的危害,并针对本次事故提出了相应的反事故措施。