我国再制造产业及其发展战略

再制造是制造业产业链的延伸,属于先进制造和绿色制造的范畴,《中国制造2025》提出要"大力发展再制造产业,实施高端再制造、智能再制造、在役再制造"。当前,我国再制造试点企业数量和再制造产品种类不断增加,再制造政策法规、基础理论、关键技术、行业标准得到不断创新完善。未来,再制造工程将向"绿色、优质、高效、智能、服务"五大方向发展,重点突破若干再制造核心关键技术,完善多个支撑体系,形成一批再制造领军产业。     

中国海洋工程科技2035发展战略研究

提高海洋资源开发能力,发展海洋经济,保护海洋生态环境,坚决维护国家海洋权益,建设海洋强国是我国重要的长期发展战略目标。从全球视野和经略海洋能力来看,我国尚处于探索和开发海洋的初步阶段,需要将海洋资源探查、工程开发利用、环境保护和国家权益维护作为有机整体,开展海洋强国建设的顶层设计。本研究通过一系列海洋跨学科交叉和集成的技术预见分析,研判我国海洋领域的重要技术方向。从海洋环境立体观测技术与装备、海底资源勘查与开发、海洋生物资源勘查与开发、海水和海洋能资源综合利用、海洋环境安全保障及海洋开发装备6个关键领域,提出了面向2035的我国海洋工程科技的愿景、发展重点、发展战略及发展途径。     

我国细菌耐药问题的现状和防控策略

细菌耐药危机日趋严峻,已经成为全球范围内的重大公共安全问题,严重危害人类、动物的健康和生态环境。本文总结了我国各领域细菌耐药问题的现状,分析了加剧细菌耐药性的直接原因,揭示了细菌耐药问题对国民健康、食品安全、生态环境、经济发展等可能造成的危害,整理了我国目前开展的防控行动以及取得的主要成果,最后针对我国细菌耐药防控在耐药监测、抗生素监管、危害风险评估、人才队伍建设等方面的不足,提出了多领域合作、多部门联防联控的细菌耐药防控策略。     

中国健康服务业发展战略研究

为落实健康中国发展战略,推进中国健康服务业的发展,中国工程院于2015年启动"中国健康服务业发展战略研究"重大咨询项目。课题自启动以来,组织了28位院士和150余位专家,对京上广深等一至三线共12个城市进行了广泛的社会调查。本文在大量社会调查的基础上,从健康服务业的概念、内涵、发展特点入手,深入分析了国内健康服务业的发展现状;以全方位、全覆盖、全过程建立健康服务保障体系为目标,对健康服务业的定位、发展思路,城乡理想模式等进行了深入探讨;并针对健康管理体系建设、养生养老、医养结合、健康保险、社会办医、金融保障等重点问题,提出了为顺应中国健康服务业发展战略顺畅实施的保障措施和相关建议。     

我国农村废弃物分类资源化利用战略研究

本文围绕我国农村废弃物分类资源化利用问题,论述了农村废弃物的产生、危害以及资源化利用的重要意义,评估了我国农村废弃物的产生量、地区分布特征及资源化利用情况,深入分析了农村废弃物资源化利用存在的突出问题,结合美丽乡村建设及农村废弃物资源化利用的发展趋势,制定了农村废弃物资源化利用的发展战略及分阶段目标,提出了我国未来农村废弃物资源化开发利用的保障措施和政策建议。     

柴达木盐湖产业生态文明建设战略研究

盐湖产业事关我国粮食安全,也是新能源和新材料产业的重要支撑。柴达木盆地是中国盐湖产业的核心,建设其产业生态文明重要而迫切。为推进柴达木盐湖产业生态文明建设,做强中国盐湖产业,本文从柴达木盐湖产业生态文明建设的现状出发,辨识产业生态文明建设面临的严峻挑战,提出了盐湖产业生态文明建设的四大战略。     

Development and validation of a Re-Modified Work-Style Short Form Questionnaire for assessment of stress in medical practitioners working in Indian hospitals

Medical practitioners are unduly stressed, leading to ill health, loss of work efficiency, sometimes affecting decision-making capability. The present study was conducted with the aim to quantify the psychosocial factors that affect the medical practitioners working in Indian hospitals. This study constructed and validated Re-Modified Work-Style Short Form Questionnaire, an eight-item instrument based on work style of 108 medical practitioners comprising Indian physicians and surgeons. The re-modified tool had acceptable validity and internal consistency, which the modified one did not. Explorative factor analysis identified and labelled three factors: ‘Working through pain’, ‘Deadlines/pressure’ and ‘Self-imposed workload’. The findings of the study reveal that the mean total work style score exceeded the standardised limits ≥16, which suggests that the work style of medical practitioners working in Indian hospitals are at risk which may precipitate psychosocial stress. Factor weights was derived through Analytic Hierarchy Process to prioritise the relative importance of three potential work-style factors. The study may help to increase the preventive strategies to proactively reduce the effect of risk factors for the precipitation of stress, successfully leading to its attenuation.     

Drug self-assembly: A phenomenon at the nanometer scale with major impact in the structure–biological properties relationship and the treatment of disease

Under water-rich conditions, small amphiphilic and hydrophobic drug molecules self-assemble into supramolecular nanostructures. Thus, substantial modifications in their interaction with cellular structures and the ability to reach intracellular targets could happen. Additionally, drug aggregates could be more toxic than the non-aggregated counterparts, or vice versa. Moreover, since self-aggregation reduces the number of effective “monomeric” molecules that interact with the target, the drug potency could be underestimated. In other cases, the activity could be ascribed to the non-aggregated molecule while it stems from its aggregates. Thus, drug self-assembly could mislead from drug throughput screening assays to advanced preclinical and clinical trials. Finally, aggregates could serve as crystallization nuclei. The impact that this phenomenon has on the biological performance of active compounds, the inconsistent and often controversial nature of the published data and the need for recommendations/guidelines as preamble of more harmonized research protocols to characterize drug self-aggregation were main motivations for this review. First, the key molecular and environmental parameters governing drug self-aggregation, the main drug families for which this phenomenon and the methods used for its characterization are described. Then, promising nanotechnology platforms investigated to prevent/control it towards a more efficient drug development process are briefly discussed.     

Theoretical analysis of shunting effect in resistance spot welding (RSW) of AA2219

Shunting effect is the loss of electrical current via the secondary circuit provided due to existence of previous nugget in a series of welding spots. This phenomenon is important for products containing intermittent spots. In this study, a theoretical model is developed for shunting effect in resistance spot welding for aluminum alloy 2219. Welding distance together with welding current and time is included in the model to analyze the shunting effect on final nugget quality. Thermal and electrical interactions are considered in the model as well as geometrical aspects of the process. Temperature dependence of material properties, integration through the whole volume of the nugget and heat-affected zone, and assuming a simple cooling mechanism are the most important modifications designated in the proposed theoretical model. Predicted results of nugget diameter are compatible with experimental and finite element analysis results.     

Prediction of color changes in acetaminophen solution using the time–temperature superposition principle

A prediction method for color changes based on the time–temperature superposition principle (TTSP) was developed for acetaminophen solution. Color changes of acetaminophen solution are caused by the degradation of acetaminophen, such as hydrolysis and oxidation. In principle, the TTSP can be applied to only thermal aging. Therefore, the impact of oxidation on the color changes of acetaminophen solution was verified. The results of our experiment suggested that the oxidation products enhanced the color changes in acetaminophen solution. Next, the color changes of acetaminophen solution samples of the same head space volume after accelerated aging at various temperatures were investigated using the Commission Internationale de l’Eclairage (CIE) LAB color space (a*, b*, L* and ΔE*ab), following which the TTSP was adopted to kinetic analysis of the color changes. The apparent activation energies using the time–temperature shift factor of a*, b*, L* and ΔE*ab were calculated as 72.4, 69.2, 72.3 and 70.9 (kJ/mol), respectively, which are similar to the values for acetaminophen hydrolysis reported in the literature. The predicted values of a*, b*, L* and ΔE*ab at 40?°C were obtained by calculation using Arrhenius plots. A comparison between the experimental and predicted values for each color parameter revealed sufficiently high R² values (>0.98), suggesting the high reliability of the prediction. The kinetic analysis using TTSP was successfully applied to predicting the color changes under the controlled oxygen amount at any temperature and for any length of time.