Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment

Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However, PSMA-TRT cannot be used for curative intent yet, thus additional research on how to improve the therapeutic efficacy is warranted. A potential way of achieving this, is combining TRT with poly ADP-ribosylation inhibitors (PARPi), which has shown promising results for TRT of neuroendocrine tumor cells. Currently, several clinical trials have been initiated for this combination for PCa, however so far, no evidence of synergism is available for PCa. Therefore, we evaluated the combination of PSMA-TRT with three classes of PARPi in preclinical PCa models. In vitro viability and survival assays were performed using PSMA-expressing PCa cell lines PC3-PIP and LNCaP to assess the effect of increasing concentrations of PARPi veliparib, olaparib or talazoparib in combination with PSMA-TRT compared to single PARPi treatment. Next, DNA damage analyses were performed by quantifying the number of DNA breaks by immunofluorescent stainings. Lastly, the potential of the combination treatments was studied in vivo in mice bearing PC3-PIP xenografts. Our results show that combining PSMA-TRT with PARPi did not synergistically affect the in vitro clonogenic survival or cell viability. DNA-damage analysis revealed only a significant increase in DNA breaks when combining PSMA-TRT with veliparib and not in the other combination treatments. Moreover, PSMA-TRT with PARPi treatment did not improve tumor control compared to PSMA-TRT monotherapy. Overall, the data presented do not support the assumption that combining PSMA-TRT with PARPi leads to a synergistic antitumor effect in PCa. These results underline that extensive preclinical research using various PCa models is imperative to validate the applicability of the combination strategy for PCa, as it is for other cancer types.     

汽车空气流量传感技术现状与发展趋势

电喷系统是汽车的核心控制系统,它以空气流量传感器测量获得的进气量为依据确定喷油量与点火时间,从而使得燃料燃烧在理论空燃比附近,以实现更好的安全性、经济性、动力性以及更低的废气排放。因此,进气量的精确测量对汽车电喷系统具有非常重要的意义。介绍了汽车电喷系统空气流量传感技术的现状、存在的问题及发展趋势,并提出了一种采用平行平板电容原理结合涡街原理的传感方式。     

竞价环境下燃煤发电企业降低发电成本的储煤优化模型

未来的发电企业需要通过竞价实现上网,竞价成功的前提是具有低于竞争对手的发电成本。燃煤发电企业每年要消耗大量的物料(燃料、水、油、备品材料),以保证生产连续、稳定、正常地运行,这些物料会形成很大的库存成本。通过对煤炭库存成本最小化的研究,构造了燃煤发电企业的储煤库存优化模型,以此确定最优库存决策,这将有利于燃煤发电企业将库存占用的资金降至合理水平,同时又能保证正常的发电运行。     

农电实现降损增效的途径讨论

线损率和抄核收到位率是农电管理的重要经济技术指标,也是农电生产经营管理水平和实现经济效益的综合反映。多管齐下,加强用电管理,降低线损率,确保抄核收工作到位是实现农电降损增效的有效途径。     

熔融碳酸盐燃料电池(MCFC)用γ-LiAlO_2粉末的制备

本文简介了熔融碳酸盐燃料电池(MCFC)及其优点;叙述了合成LiAlO_2的方法,用Al_2O_3(a,γ)成功地制得了稳定的适合于MCFC用的γ-LiAlO_2,在MCFC工作温度(923K)下,β-LiAlO_2是不稳定的;973-1073K时,β-LiAlO_2向γ-LiAlO_2转变速度明显增大;a-LiAlO_2要在1073K以上转变为γ-LiAlO_2.     

水电机组调峰服务的成本分析及实用补偿方法

首先分析了在电力系统运行实践中,调峰服务的内涵及其与备用服务的关系;进而研究了水电调峰成本组成,指出水电机组调峰成本应重点考虑其有功出力频繁调整引起效率损失的机会成本。参照当前国内辅助服务管理实际,并结合水电实际运行特点,给出了水电调峰补偿的测算方法。具体测算思路以水电机组日平均出力为基准,上下各浮动一定比例形成基本调...     

越流区承压含水层特殊脆弱性评价模型的参数灵敏度分析

承压含水层特殊脆弱性评价中存在着诸多不确定性因素,影响评价结果的可靠性。本文分别运用局部灵敏度分析和Morris法的全局灵敏度分析对承压含水层特殊脆弱性评价模型中的参数进行灵敏度分析,为提高模型评价结果的可靠性奠定了基础。以济宁市承压含水层特殊脆弱性评价为例,对模型中各参数灵敏度进行分析。结果表明：弱透水层厚度、承压水与潜水水头差、弱透水层垂向渗透系数对承压含水层脆弱性评价模型的影响最为显著,弱透水层密度、分配系数与有效孔隙度对模型的影响次之,潜水含水层中污染物浓度与弱透水层弥散度对模型的影响最小;全局灵敏度分析结果显示,除弥散度外的各参数灵敏度系数的绝对值随着承压含水层脆弱等级的升高而降低。     

燃料棒中铯活度比A(~(134)Cs)/A(~(137)Cs)的轴向分布测量与分析

在热室中 ,用γ扫描装置对秦山核电厂 3× 3 -2考验组件中辐照历史、燃耗及冷却时间不同的两根燃料棒中的铯活度比A(13 4 Cs) /A(13 7Cs)的轴向分布进行了测量 ,并利用自行开发的压水堆燃料棒破损特性分析程序FCAC进行了理论计算。结果表明 :辐照和停堆冷却过程中燃料棒中铯原子的轴向迁移可以忽略 ,燃料棒中铯活度比的轴向分布由燃耗的轴向分布决定。     

国内外能源利用效率比较及对我国的启示

经济增长与能源消耗之间有着密切的关系。通过对快速增长的新兴经济体以及经历类似阶段的发达国家的能源利用效率的比较和政策的分析,指出我国能源问题的原因在于生活、建筑能耗方面及高耗能行业的过度消耗,进而提出规范市场、优化产业结构等政策建议,从而实现使经济发展走上资源节约型、环境友好型的良性循环这一目标。