松材线虫病害高光谱时序与敏感特征研究

采用高光谱仪ASD FieldSpec Pro FR,连续观测了健康和发病马尾松针叶的时序高光谱,分析了松材线虫病害光谱的时序特征、敏感时期和敏感特征。结果表明:与健康马尾松相比,病害马尾松时序光谱差异较大;病害首先造成红边区域内光谱反射率减低,然后再出现红边蓝移的2阶段光谱变化规律;感染松材线虫的马尾松9月初已经出现了病态植被典型的光谱特征;近红外平台内最大的一阶微分值、红边内一阶微分的总和(SDr)与蓝边内一阶微分的总和(SDb)的比值等是指示病害发生的显著性高光谱特征。     

Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP). Kidney fibrosis develops in response to increased deposition of extracellular matrix (ECM), and up-regulation of collagen I is an early marker of renal disease. With ECM remodeling known to promote a loss of epithelial stability, in the current study we used a clonal human kidney (HK2) model of proximal tubular epithelial cells to determine if collagen I modulates changes in cell function, via connexin-43 (Cx43) hemichannel ATP release. HK2 cells were cultured on collagen I and treated with the beta 1 isoform of the pro-fibrotic cytokine transforming growth factor (TGFβ1) ± the Cx43 mimetic Peptide 5 and/or an anti-integrin α2β1 neutralizing antibody. Phase microscopy and immunocytochemistry observed changes in cell morphology and cytoskeletal reorganization, whilst immunoblotting and ELISA identified changes in protein expression and secretion. Carboxyfluorescein dye uptake and biosensing measured hemichannel activity and ATP release. A Cytoselect extracellular matrix adhesion assay assessed changes in cell-substrate interactions. Collagen I and TGFβ1 synergistically evoked increased hemichannel activity and ATP release. This was paralleled by changes to markers of tubular injury, partly mediated by integrin α2β1/integrin-like kinase signaling. The co-incubation of the hemichannel blocker Peptide 5, reduced collagen I/TGFβ1 induced alterations and inhibited a positive feedforward loop between Cx43/ATP release/collagen I. This study highlights a role for collagen I in regulating connexin-mediated hemichannel activity through integrin α2β1 signaling, ahead of establishing Peptide 5 as a potential intervention.     

Quality of life development during initial hemodialysis therapy and association with loss of residual renal function

Introduction: Health related quality of life (HRQOL) is markedly reduced in hemodialysis patients compared to the general population. We investigated the course of self‐reported HRQOL over time and the association with selected factors, focusing on changes in glomerular filtration rate (GFR). Methods: Eighty‐two newly started hemodialysis patients from the SAFIR cohort filled out the Kidney Disease Quality of Life Short Form Version 1.3 (KDQOL‐SF^TM) questionnaire at baseline, 6 and 12 months. The SAFIR study was a randomized, placebo‐controlled, double‐blind intervention study, examining the effects of the angiotensin II receptor blocker irbesartan. HRQOL was a secondary outcome measure. Main inclusion criteria: Dialysis vintage <1 year, left ventricular ejection fraction >30% and urinary output >300 mL/day. GFR was measured with mean creatinine and urea clearance from 24‐hour urine collections at baseline, 6 and 12 months. Findings: Irbesartan treatment did not affect HRQOL. Patients were pooled into one group for further analyses. Decline in GFR correlated significantly with decreasing HRQOL over time. HRQOL was stable over time, with a slight nonsignificant tendency toward improved HRQOL. The largest HRQOL‐differences (positive values equal improved HRQOL) observed during the 12 month study period were (mean[95% confidence interval]): Burden of kidney disease:6.4[?2.2;15.0], Role limitations‐physical:12.7[?2.1;27.5], and Role limitations‐emotional:9.7[?5.2;24.6]. Comorbidity, especially diabetes, hospital admissions, female gender, and age were strongly associated with lower HRQOL in cross sectional analysis. Discussion: Preservation of residual renal function seems to be important for HRQOL. In newly started HD patients, HRQOL showed little change after 12 months. HRQOL was negatively affected by comorbidity, especially diabetes, hospital admissions, female gender, and age.     

654例高校妇女病检查结果分析

为了解高校女教职工妇女病患病情况、做好妇女保健提供依据,本文对2011年我校女教职工妇女病检查结果进行统计分析。结果显示全校女教职工1139人,2011年参加妇检的女教职工共计654人,参检率57.42%,参检率较低。654名参检人员中,最常见的妇科疾病是宫颈炎、乳腺增生,分别占患病人数的44.65%和41.53%,其次是子宫肌瘤、阴道炎,分别占患病人数的6.18%和4.87%。从结果中可以看出高校女教职工参检率低、患妇女病率偏高,应提高保健意识,充分认识到定期体检的重要性。     

The vibration characteristics of chain saws and their influence on vibration white finger disease

The vibration from chain saws can cause vibration-induced white finger disease (VWFD). Measurements of vibration levels on the front and rear handles of different chain saw-types, and on the operator's middle finger were collected at three logging camps on Vancouver Island. Factors effecting the vibration levels on the finger and handles were investigated. The acceleration at the firing frequency was found to be the dominant factor effecting handle and finger vibration. Other factors which were investigated were: grip force; the presence of handle covers; and chain sharpening procedure. Weighted acceleration levels are calculated and this information is used to assess the latency period for fallers to develop VWF disease.     

Olfactory and auditory event-related potentials in Huntington's disease.

The influence of Huntington's disease (HD) on the olfactory event-related potential (OERP), an electrophysiological measure of olfactory information processing, has not been reported to date. In the present study, olfactory and auditory event-related potentials (ERPs) were recorded monopolarly from Fz, Cz, and Pz electrode sites in 8 patients with HD and 8 age- and gender-matched control participants. Results demonstrated that individuals with HD were delayed compared with controls on the P3 component of the OERP (p     

Classification of heart rate data using artificial neural network and fuzzy equivalence relation

The electrocardiogram is a representative signal containing information about the condition of the heart. The shape and size of the P-QRS-T wave, the time intervals between its various peaks, etc. may contain useful information about the nature of disease afflicting the heart. However, these subtle details cannot be directly monitored by the human observer. Besides, since bio-signals are highly subjective, the symptoms may appear at random in the time scale. Therefore, the signal parameters, extracted and analysed using computers, are highly useful in diagnostics. This paper deals with the classification of certain diseases using artificial neural network (ANN) and fuzzy equivalence relations. The heart rate variability is used as the base signal from which certain parameters are extracted and presented to the ANN for classification. The same data is also used for fuzzy equivalence classifier. The feedforward architecture ANN classifier is seen to be correct in about 85% of the test cases, and the fuzzy classifier yields correct classification in over 90% of the cases.     

基于多智能体的疾病传染仿真研究

该文在对疾病传染问题研究的基础上，提出采用基于多智能体的方法建立疾病传染过程的基于多智能体仿真模型，通过对所建立模型仿真结果的分析研究，得到在起始病人数量不同，传染率、治愈率、传染规则不同和不同的人口密度环境下的疾病传染过程和传播规律，并据此提出了控制疾病传播的一些有益建议和方法。     

Education-Stratified Base-Rate Information on Discrepancy Scores Within and Between the Wechsler Adult Intelligence Scale-Third Edition and the Wechsler Memory Scale-Third Edition.

The Wechsler Adult Intelligence Scale--Third Edition (WAIS-III; D. Wechsler, 1997a) and the Wechsler Memory Scale--Third Edition (WMS-III; D. Wechsler, 1997b) are 2 of the most frequently used measures in psychology and neuropsychology. To facilitate the diagnostic use of these measures in the clinical decision-making process, this article provides information on education-stratified, directional prevalence rates (i.e., base rates) of discrepancy scores between the major index scores for the WAIS-III, the WMS-III, and between the WAIS-III and WMS-III. To illustrate how such base-rate data can be clinically used, this article reviews the relative risk (i.e., odds ratio) of empirically defined "rare" cognitive deficits in 2 of the clinical samples presented in the WAIS-III--WMS-III Technical Manual (The Psychological Corporation, 1997). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Clinical trials among worker populations: a model for an anamnestic survey of upper limb pathologies and its practical application methods

Following a brief review of the principal clinical characteristics of musculoskeletal disorders of the upper limbs, the authors propose a protocol for a structured anamnestic examination featuring a series of set questions. The anamnestic model is based on a detailed listing of the symptoms to be analysed, which are divided into four categories: pain, paraesthesia, symptoms attributable to hyposthenia, and neurovegetative disorders. Regarding pain and paraesthesia, the authors list the localization, pattern of onset, duration and number of episodes, irradiation and treatment. The patients can thus be classified as anamnestic cases based on the following criteria: presence of pain or paraesthesia during the last 12 months, with episodes lasting for at least 1 week or occurring at least once a month, with no previous acute trauma. For hyposthenia, the authors report on the conditions under which the disorder may develop. The neurovegetative disorders considered are modifications in colour of the fingers and reaction to exposure to low temperatures. The structure of the proposed anamnestic chart permits all findings to be easily encoded for subsequent storage in a dedicated database. The appendix contains an annotated facsimile of the anamnestic chart.