失业者可免费用Flex Builder 3

Adobe将为失业开发人员提供免费的Flex Builder 3许可。Adobe官方表示，将其作为“入门”包的一部分，使得失业开发人员能扩展技能、学会如何用Flex构建Web应用。“入门”包还包括开发活动相关的培训和信息，并能让开发人员访问社区中的资源，以帮助他们找到工作。     

基于5G技术的VR-定制旅游-沉浸式服务新型平台设计

YOU伴旅团队研发为用户提供私人订制、保姆级守护服务、沉浸式出游体验,为用户带来沉浸式全放松、线上预订线下接送的全包式服务体验新型定制出行软件.文章分析了该APP可行性,并对设计概念、APP设计、资源整合模式、技术依托、功能实现5个板块作阐述.     

聚磷酸铵及其酯化的生产工艺

以磷酸和尿素为原料,制备聚磷酸铵无机阻燃剂。考察磷酸、尿素、反应温度和固化温度对聚磷酸铵平均聚合度的影响,用红外光谱分析法表征聚磷酸铵的晶体结构。以聚磷酸铵和季戊四醇为主要原料,合成具有一定含氮量的聚磷酸酯并采用红外光谱分析。     

含磷三嗪环聚合物阻燃聚丙烯材料的制备及性能

利用自制的三嗪环低聚物(PMPT)及复合阻燃剂制备阻燃聚丙烯材料,研究复合阻燃剂APP/PER/PMPT用量对阻燃PP力学性能、热分解性能的影响,并初步推测阻燃剂PMPT的阻燃机理.结果表明:加入复合阻燃剂使阻燃PP的力学性能有所下降.TG曲线显示:复合阻燃剂使阻燃PP的热分解速率减小,热稳定性增加.复合阻燃剂APP/PER/PMPT使PP的氧指数(LOI)增加62%.APP/PER/PMPTF复合阻燃剂主要在凝聚相起到阻燃作用.     

无规聚丙烯热熔胶的制备及其改性研究

研究了不同配比的增黏剂、黏度调节剂、增塑剂和填充剂等对无规聚丙烯(APP)热熔胶性能的影响;以甲基丙烯酸甲酯(MMA)、丙烯酸丁酯(BA)和苯乙烯(St)等对APP进行熔融接枝改性,得到改性APP接枝物(即APP-g-St-MMA-BA);通过可视化优化法优选出制备APP热熔胶和APP-g-St-MMA-BA的最佳配方。结果表明:制备APP热熔胶的最佳配方为m(APP4型)∶m(APP5型)∶m(氢化C9树脂)∶m(轻质CaCO3)∶m(合成蜡)∶m(邻苯二甲酸二丁酯)=42.9∶57.1∶55∶14.0∶11.0∶3;制备APP-g-St-MMA-BA的最佳配方为m(APP5型)∶m(过氧化二异丙苯)∶m(MMA)∶m(BA)∶m(St)=20∶0.24∶2.16∶1.00∶1.24;APP-g-St-MMA-BA的耐热性能明显优于APP。     

Experimental investigation of flame retardancy and mechanical properties of APP/EG/TPU multilayer composites prepared by microlayer coextrusion technology

In this paper, ammonium polyphosphate(APP)/expandable graphite(EG)/thermoplastic polyurethane (TPU) composites were prepared by microlayer coextrusion technology, APP and EG fillers had good synergistic flame retardancy and excellent dispersion in TPU matrix, which greatly improved the flame retardancy and mechanical properties of multilayer composites. The dispersion of APP and EG in TPU was characterized by using SEM, the flame retardancy of composites was characterized by using UL94 and LOI, the thermal stability of composites was characterized by using TGA and DTG, and tensile test was used to characterized the mechanical properties of composites. SEM showed that the microlayer coextrusion technology significantly improved the dispersion of APP and EG in TPU. As showed by the experimental results, the vertical combustion level of ordinary blended composites reached V-2 after adding only one kind of filler either APP or EG, and the vertical combustion level of ordinary blended composites reached V-0 with APP and EG applied together, while the vertical combustion level of microlayer coextruded composites all reached V-0 when the total addition of APP and EG was 15%. In particular, the LOI value of microlayer coextruded composites was 30.9%, while the LOI value of ordinary blended composites only was 27.9% when APP: EG = 1: 1. At this time, the flame retardancy level of APP/EG/TPU composites was the best. In addition, the thermal stability and mechanical properties of microlayer coextruded composites were far superior to ordinary blended composites. In conclusion, the synergistic flame retardancy of APP and EG fillers and the dispersion of APP and EG fillers in TPU matrix played a significant role in enhancing flame retardancy and mechanical properties.     

CK1δ-Derived Peptides as Novel Tools Inhibiting the Interactions between CK1δ and APP695 to Modulate the Pathogenic Metabolism of APP

Alzheimer’s disease (AD) is the major cause of dementia, and affected individuals suffer from severe cognitive, mental, and functional impairment. Histologically, AD brains are basically characterized by the presence of amyloid plaques and neurofibrillary tangles. Previous reports demonstrated that protein kinase CK1δ influences the metabolism of amyloid precursor protein (APP) by inducing the generation of amyloid-β (Aβ), finally contributing to the formation of amyloid plaques and neuronal cell death. We therefore considered CK1δ as a promising therapeutic target and suggested an innovative strategy for the treatment of AD based on peptide therapeutics specifically modulating the interaction between CK1δ and APP. Initially, CK1δ-derived peptides manipulating the interactions between CK1δ and APP695 were identified by interaction and phosphorylation analysis in vitro. Selected peptides subsequently proved their potential to penetrate cells without inducing cytotoxic effects. Finally, for at least two of the tested CK1δ-derived peptides, a reduction in Aβ levels and amyloid plaque formation could be successfully demonstrated in a complex cell culture model for AD. Consequently, the presented results provide new insights into the interactions of CK1δ and APP695 while also serving as a promising starting point for further development of novel and highly innovative pharmacological tools for the treatment of AD.     

ZigBee技术在智能公交管理系统中的应用及系统综合评价

设计了一种基于ZigBee和3G模块的智能公交系统,对系统组成和开发技术做了详尽说明。本系统由公交车与站台无线通讯系统、专用网络服务器数据库系统、移动客户端APP等部分组成,通过ZigBee自组织网络和3G网络实现通信。建立层次分析模型,量化指标体系,对系统的公交协调能力进行综合评价。结果表明,服务指标和经济效益权重较大,系统综合效益较好。     

胸膜肺炎放线杆菌血清型特异的疫苗候选基因的筛选及痤疮丙酸杆菌异源免疫

目的筛选猪胸膜肺炎放线杆菌(APP)1型与5型特异的疫苗候选基因,并研究痤疮丙酸杆菌对猪传染性胸膜肺炎的异源免疫。方法采用cDNA代表性差异分析、大肠杆菌核糖体展示、免疫筛选和RT-PCR技术筛选APP1型和5型血清型特异的疫苗候选基因,进行克隆、测序及同源序列分析。并用与APP疫苗候选基因具有同源序列的痤疮丙酸杆菌(PA)免疫小鼠,研究其对APP感染的异源免疫。结果获得血清1型APP6条疫苗候选基因,2条为未知基因,2条与PA同源性为98%,2条与人cDNA有同源性。获得血清5型APP7条疫苗候选基因,其中2条为未知基因,2条与PA同源性分别为93%和100%。用PA全菌免疫小鼠,产生的抗血清可与1型和5型APP发生强的免疫反应,ELISA检测效价达1∶3200;脾淋巴细胞检测结果显示,免疫组CD3+、CD4+T细胞的百分率及CD4+/CD8+比值与对照组相比均升高,两组CD3+T细胞百分率差异有显著意义。以10倍LD501型和5型APP分别感染PA免疫小鼠,小鼠存活率分别为95%和90%,并且在攻毒后第15天体内APP可全部被清除。结论1型与5型APP存在不同的疫苗候选基因,痤疮丙酸杆菌与之存在共同抗原,能够产生交叉免疫应答,对血清1型和5型APP的感染具有预防作用。     

无规聚丙烯-橡胶篷布的研制

研究了无规聚丙烯与天然橡胶并用制备篷布的配方。试验了APP（无规聚丙烯）、硫化剂、硫黄、促进剂、添加剂等对胶料性能的影响。结果表明,在胶料中用一定量的APP取代天然胶时,仍能满足企业标准,但却显著降低了成本,提高了经济效益。