Automatic classification and prediction models for early Parkinson’s disease diagnosis from SPECT imaging

Early and accurate diagnosis of Parkinson’s disease (PD) is important for early management, proper prognostication and for initiating neuroprotective therapies once they become available. Recent neuroimaging techniques such as dopaminergic imaging using single photon emission computed tomography (SPECT) with ¹²³I-Ioflupane (DaTSCAN) have shown to detect even early stages of the disease. In this paper, we use the striatal binding ratio (SBR) values that are calculated from the ¹²³I-Ioflupane SPECT scans (as obtained from the Parkinson’s progression markers initiative (PPMI) database) for developing automatic classification and prediction/prognostic models for early PD. We used support vector machine (SVM) and logistic regression in the model building process. We observe that the SVM classifier with RBF kernel produced a high accuracy of more than 96% in classifying subjects into early PD and healthy normal; and the logistic model for estimating the risk of PD also produced high degree of fitting with statistical significance indicating its usefulness in PD risk estimation. Hence, we infer that such models have the potential to aid the clinicians in the PD diagnostic process.     

纺织企业的原料库存控制模型研究

合理控制库存量,降低原料库存成本对纺织企业提高市场竞争力具有重大的意义。通过建立原料库存的不定量不定期控制模型,并采用遗传算法求解,给出了满足平均库存成本最小的(s,S)控制策略,并通过实例验证算法的有效性。     

项目式教学在职业教育中对学生承诺的考核方法的研究

在中职、高职类院校,项目式教学正在被推广,在项目式教学模式下,我们把实际的企业项目带到课堂,同时,我们也希望借鉴有益的企业对员工的评价方法。基于此,提出在原有的项目式评价学生体系下,增加对学生承诺的考核方法,并给出切实可操作的研究方案。增加对学生承诺的考核旨在充分发掘学生的潜能,对超出学生承诺的专业能力的成绩给予鼓励。     

In-situ monitoring of the stabilization with hydrogen of free radicals thermally induced from coal using high pressure e.s.r., d.t.a. and p.d.a. equipment

High temperature, high pressure e.s.r. measurements of the hydrogenation reaction of Taiheiyo coal in the presence of catalysts were carried out to understand the stabilization of thermally and/or catalytically induced free radicals. A decrease in free radical concentration with increasing temperature was observed for ZnCl₂ and SnCl₂ · 2H₂O catalysts at 10MPa under hydrogen gas. High pressure modified single-cell d.t.a. and p.d.a. equipment augmented the uniquely designed high temperature, high pressure e.s.r. cell. The hydrogenation reaction was monitored under the same experimental conditions as for e.s.r. From the results of the combination of high temperature, high pressure e.s.r. with high pressure d.t.a. and p.d.a., it was established that H₂ molecules can react efficiently with free radicals from coal molecules created by the presence of ZnCl₂ and SnCl₂ · 2H₂O catalysts.     

A parametric frequency response method for non-linear time-varying systems

A new parametric frequency response algorithm is introduced to investigate linear and non-linear dynamic systems with time-varying parameters. In the new algorithm the time-varying parameters are regarded as additional inputs of the systems and the non-linear generalised frequency response functions for multi-input-single-output systems are then employed to obtain Zadeh's system functions from a differential equation representation. The parametric frequency response method reveals how the time-varying parameters affect the behaviour of the systems through a time-varying term. The new method can be applied to both linear and non-linear time-varying systems.     

Adaptive tracking control of an autonomous underwater vehicle

This paper presents the trajectory tracking control of an autonomous underwater vehicle(AUV). To cope with parametric uncertainties owing to the hydrodynamic effect, an adaptive control law is developed for the AUV to track the desired trajectory. This desired state-dependent regressor matrix-based controller provides consistent results under hydrodynamic parametric uncertainties.Stability of the developed controller is verified using the Lyapunov s direct method. Numerical simulations are carried out to study the efficacy of the proposed adaptive controller.     

基于S120变频器的转炉倾动主从控制设计及应用

随着SINAMICS S120在工控领域的应用,越来越多的成功应用案例随之产生,主从控制方案就是一个典型的案例,在许多工业领域得到了应用.本文主要介绍了转炉倾动控制系统的主从控制方案设计,实现变频器主从自动切换的调试过程及注意事项.