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51.
^153Sm—EDTMp在羟基磷灰石上的吸附 总被引:11,自引:0,他引:11
用HA作骨体外模型,研究了配合物^153Sm-EDTMP在HA上的吸附规律和几种共存离子对吸附和解吸的影响。在pH=7.0±0.2的条件下,体系中配合物量≤40μmol/(g HA),吸附定量进行;当配合物量〉40μmol/(g HA),则不能定量吸附。 相似文献
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153Sm-EDTMP和博宁治疗恶性肿瘤骨转移骨痛的疗效比较 总被引:2,自引:0,他引:2
为比较放射性药物^153Sm-EDTMP和化疗药物博宁对恶性肿瘤骨转移骨痛的疗效,将恶性肿瘤骨有痛患者18例随机分为^153Sm组和博宁组各9例进行分组治疗,采用骨痛状况评分标准,对患者治疗前后骨痛状况进行评分。受试者治疗前骨痛评分均≥6分;止痛效果采用4级评定法。结果:^153Sm-EDTMP组9例中2例好转,7例显效,无完全缓解,有效率为77.8%;博宁组9例中无效和加理4例,1例好转,显效3例,完全缓解1例,有效率44.4%,^153Sm-EDTMP对骨髓抑制制作为一过性,博宁无明显骨髓抑制作用;^153Sm-EDTMP与博宁治疗恶性肿瘤骨转移骨痛有效率相近(P=0.3348),且疼痛减轻持续3周以上,但一过性血液毒性比博宁略为显著。 相似文献
54.
《Journal of Nuclear Science and Technology》2013,50(10):711-719
Neutron capture cross sections of europium isotopes 151Eu and 153Eu were measured in the neutron energy range of 3~100keV. Experiments were carried out with the time-of-flight facility at the 52 m station of the JAERI Electron Linear Accelerator. Prompt capture γ-rays were detected by a large liquid scintillation detector and the neutron flux shape was determined with a 6Li glass scintillation detector. The average capture cross sections were examined in terms of energy independent strength functions for 151Eu and 153Eu. 相似文献
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Watson MD 《Yeast (Chichester, England)》2001,18(5):473-480
Six open reading frames (ORFs) of unknown function from the right arm of Saccharomyces cerevisiae chromosome XII were deleted in two genetic backgrounds by disruption cassettes with regions of short flanking homology. This work was carried out within the framework of the EUROFAN consortium. The SFH disruption cassettes, obtained by PCR, were made by amplification of the kanMX marker module with oligonucleotides containing approximately 40 bp of homology to either the promoter or translation terminator regions of the relevant ORF. Transformants resistant to geneticin (G418) were selected. The SFH disruption cassettes were cloned into a bacterial vector. Each cognate gene was also cloned into a yeast centromeric plasmid. Sporulation and tetrad analysis of the disrupted heterozygous strains revealed that ORF YLR153c (now known as ACS2) is essential. Basic phenotypic analysis was performed on haploid deletants of both mating types of the five non-essential ORFs, YLR082c (now known as SRL2), YLR149c, YLR151c, YLR152c and YLR154c. Plate growth tests on different media at 15 degrees C, 30 degrees C and 37 degrees C did not reveal any significant differences between parental and mutant cells. Mating and sporulation efficiencies were not affected in any of the viable disruptants as compared to wild-type cells. 相似文献
57.
Osmoderma eremita (Scopoli) is an endangered scarab beetle living in hollow trees. It has mainly been known for its characteristic odor, typically described as a fruity, peachlike or plumlike aroma. The odor emanating from a single beetle can sometimes be perceived from a distance of several meters. In this paper, we show that the characteristic odor from O. eremita is caused by the compound (R)-(+)--decalactone, released in large quantities mainly or exclusively by male beetles. Antennae from male and female beetles responded in a similar way to (R)-(+)--decalactone in electroantennographic recordings. Field trapping experiments showed that (R)-(+)--decalactone is a pheromone attracting female beetles. Lactones similar to (R)-(+)--decalactone are frequently used as female-released sex pheromones by phytophagous scarabs. This is, however, the first evidence of a lactone used as a male-produced pheromone in scarab beetles. We propose that the strong signal from males is a sexually selected trait used to compete for females and matings. The signal could work within trees but also act as a guide to tree hollows, which are an essential resource for O. eremita. Males may, thus, attract females dispersing from their natal tree by advertising a suitable habitat. This signal could also be exploited by other males searching for tree hollows or for females, which would explain the catch of several males in our traps. 相似文献
58.
引入Ca^2 、Fe^3 、Zn^2 等金属离子和氨基酸、柠檬酸、乳酸等小分子配体建立了血液的金属离子-小分子配体热力学平衡模型,通过在该模型中添加Sm^3 与小分子配体以及EDTMP与金属离子的热力学稳定常数,模拟分析了^153Sm-EDTMP在血液中的平衡组分。结果表明,体外水溶液中,在pH7.4时,EDTMP主要以[EDTMPH2]^-6和[EDTMPH3]^-5形式存在,体系pH越低,配体平衡组分所含负电荷越少;相反,体系pH越高,配体含负电荷愈多,说明高pH有利于配合物的制备,同时也说明较高pH有利于配合物的稳定。体外研究还表明,Sm—EDTMP在体外主要以[Sm-EDTMP]^-5、[Sm-EDTMPH-1]^-6、[Sm—EDTMPH]^-4等含高负电荷的配合物形式存在,说明如果配合物在体内不发生大的组分变化,则通过肾排泄,不会有高的肝摄取。体内组分分析显示,配合物在血液中主要以[Sm—EDTMPH]^-4形式存在,说明即使在体内达到热力学平衡,配合物仍会经肾排泄;配合物的高负电荷说明配合物与HA的Ca^2 有强静电吸附能力,提示配合物有较高的HA摄取。 相似文献
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60.
ZHuShoupeng 《核技术(英文版)》1999,10(1):5-7
The apoptosis in bone tumor cells is studied after ^153Sm-EDTMP irradiation.Fragmented DNA is analyzed by agarose gel electrophoresis.Experimental observations show that 153Sm-EDTMP exposure induces the internucleosomal DNA damage in bone tumor cells the DNA ladder pattern formation in bone tumor cells is show.At the same time,the microautoradiographic study indicates that ^153Sm-EDTMP could permeate through cell membrane and duisplays membrane-seeking condensation in bone tumor cells.Soon afterwards ^153Sm-EDTMP could be phagocytized by the tuymor cells and distributed in cytoplasm as well as nucleus in the form of phagosome.with the prolongation of observing time,the membrane-bounded apoptotic bodies are observed. 相似文献