羟基磷灰石对153Sm-HEDTMP的吸附性能研究

研究了各种因素对153Sm-HEDTMP(羟乙基乙二胺三甲撑膦酸)在羟基磷灰石(HA)上吸附的影响。结果表明,室温下153Sm-HEDTMP在HA上吸附20 min即可达到平衡,温度对吸附量影响不明显;过量配体会使配合物吸附量降低;吸附量在酸性条件下较高,153Sm3 在HA上的吸附能力最强,饱和吸附容量可达720μmol.g-1;153Sm-HEDTMP饱和吸附容量为61μmol.g-1;Ca2 对吸附有强烈的促进作用。EDTMP和HEDTMP对配合物的解吸率较高;生理盐水的解吸作用不明显。     

钐-153标记的多胺甲基膦酸化合物的研究

合成了8种有机胺膦酸类配位体,进行了与153Sm的配位试验,研究了酸度、温度、时间等条件的影响,得到了最佳标记条件,并进行了小鼠体内生物分布试验。结果表明,其中4种配合物在骨中有较高的浓集,注射后2h骨的摄取率均在20%·g-1以上,骨与肌肉的摄取比接近200,这与目前临床应用的153SmEDTMP基本一致,因此具有药用价值,值得进一步研究。     

Neutron capture cross section measurements of 151,153Eu using a pair of C6D6 detectors

We have measured the neutron capture cross sections of ¹⁵¹Eu and ¹⁵³Eu by the time-of-flight (TOF) method in the range from 0.005 eV to keV region using the Kyoto University Research Reactor Institute - Linear Accelerator (KURRI-LINAC). We employed a pair of C₆D₆ liquid scintillators for the prompt capture γ-ray measurement. The pulse-height weighting technique was employed to obtain the capture yields from the γ-ray spectra of ^151,153Eu. The obtained thermal cross sections at 0.0253 eV are 9051 ± 683 b for ¹⁵¹Eu and 364 ± 44 b for ¹⁵³Eu, respectively. The resonance integrals have been derived as 3490 ± 162 b for ¹⁵¹Eu and 1538 ± 106 b for ¹⁵³Eu.

The obtained capture cross sections were compared with the previously reported experimental data and the evaluated data. The evaluated data in JENDL-4.0 and JEFF-3.2 show good agreement with the present experiment results of ¹⁵¹Eu, however, the evaluated data in ENDF/B-VII.1 are larger than the present experiment results of ¹⁵¹Eu about 10% to 20% in the energy region from 0.03 to 0.2 eV. For the neutron capture cross sections of ¹⁵³Eu, the evaluated data in ENDF/B-VII.1 and Widder's data are in good agreement with the present results in the energy region below 0.35 eV.     

~(117)Sn~m(~(188)Re、~(153)Sm)-EDTMP的制备及在小鼠体内的生物分布比较

本工作通过合成得到配体EDTMP,制备出标记率较高的117Snm(188Re、153Sm)配合物。对3种配合物的体外稳定性、亲脂性进行了考察;对其生物分布作了初步探索,评价了188Re-EDTMP、117Snm-EDTMP作为骨肿瘤治疗药物的可能性。结果表明,3种配合物都易于被骨摄取,但188Re-EDTMP的体内稳定性较差,容易被洗脱,需要进一步改善;与已用于临床应用的153Sm-EDTMP相比,117Snm-EDTMP的小鼠体内分布与其趋势比较一致,在靶组织(脑骨和四肢骨)上的浓集率较高,显示出可用于骨系统疾病治疗的可能性,有进一步研究的价值。     

高活度^153Gd源芯体的研制

~(153)Gd骨密度计源芯体的烧结工艺为:将加有4%石蜡的~(153)Gd_2O_3粉末于专用模具中压制成形,再于1400℃氢气气氛中烧结成直径3mm、厚度1mm及放射性活度大于3.7×10~(10)Bq的骨密度计源陶瓷芯体。     

Modelling the chilling of the leg, loin and shoulder of beef carcasses using an evolutionary method

An evolutionary algorithm was used to adjust unknown parameters during the beef cooling process. These parameters are the equivalent diameter and the initial temperature profile, which are difficult to estimate given the irregular geometry, the elapsed time after slaughter and variations in both the air temperature and velocity. The adjusted parameters produced accurate predictions of the center and surface temperature profiles of the leg, loin and shoulder. The adjusted dimensions agreed very well with the measured carcass dimensions. Empirical equations were obtained to correlate this diameter with the weight and fat grade of beef carcasses.     

Fluorescence microscopic morphology and inhibition rate studies on apoptosis of osteosarcoma cells induced by 153Sm

The apoptosis of osteosarcoma cells treated with irradiation by ^153Sm－EDTMPwas studied,The morphological changes in osteosarcoma cells were observed by fluorescence microscopy,It was found that osteosarcoma cells exposed with ^153Sm－EDTMP displayed significant nuclear fragmentation and marked pyknosis ,With the prolongation of observing period,the membrane bound apoptotic bodies formation was observed,It should be noted,that with the lenghening of irradiation time by ^153Sm－EDTMP,the inhibiton rate of proliferation of osteosarcoma cells increased progressively.