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1-脱氧野尻霉素(DNJ)是中药桑叶降血糖组分多羟基生物碱中的一种重要成分,研究膜分离技术结合树脂法富集纯化桑叶水提物浸膏中的DNJ,建立用于DNJ定量分析的高效液相色谱-示差折光检测法.将桑叶水提物浸膏预处理后经氧化铝陶瓷膜微滤与聚醚砜膜超滤富集,然后再利用三种树脂进行纯化,所得产品用高效液相色谱-示差折光检测法测定其中DNJ的质量分数.经过膜分离技术富集后,桑叶水提物浸膏中DNJ的质量分数从1.32%提高到7.84%,收率为88.06%;经树脂纯化后DNJ的质量分数达到51.19%,总收率为12.28%.本研究首次采用微滤与超滤结合技术富集DNJ,优势明显,不仅工艺流程简单、快速,而且产品中DNJ的质量分数与收率均较高. 相似文献
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运用比较史学的原理,对森英惠、三宅一生、川久保玲三位服装设计师的专业道路、作品、设计理念初步进行了比较研究,确认其在吸收西方文化和保持东方成分方面的差异.这对当前中国服装走向世界提出了有益的借鉴和参考. 相似文献
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In the present work, the flexural and vibration response of a functionally graded plate resting on Pasternak elastic foundation is analyzed using a recently developed nonpolynomial higher-order shear and normal deformation theory by the authors. The novelty of this theory is that it contains only four unknowns and also accommodates the thickness stretching effect. Two kinds of micromechanics models, namely, the Voigt and Mori–Tanaka models, are considered. Material properties of the functionally graded plates are assumed to vary continuously in the thickness direction according to either a simple power law or an exponential law. Finite element formulation is done using C° continuous Lagrangian quadrilateral nine-noded elements with eight degrees of freedom per node. The equations of motion are derived using a variational approach. Convergence and comparison studies are carried out to establish the authenticity and reliability of the solutions. The effect of various boundary conditions, geometric conditions, micromechanics models, and foundation parameters on the flexural and vibration response of the functionally graded plate are investigated. 相似文献
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目的:探讨桑白皮生物碱与辛伐他汀联用对高脂血症金黄地鼠的降脂作用。方法:以高脂饲料喂养金黄地鼠6周建立高脂血症模型,将40只金黄地鼠随机分为正常组、模型组、桑白皮生物碱组(25 mg·kg-1·d-1),辛伐他汀组(15 mg·kg-1·d-1)和联合用药组(桑白皮生物碱25 mg·kg-1·d-1,辛伐他汀15 mg·kg-1·d-1),灌胃给药2周后心脏采血测定TG、TC、LDL-C、HDL-C等血生化指标以及ALT、AST、CRP、NO、Lp-PLA2水平;肝脏HE染色观察病理改变,油红O染色观察肝细胞脂质沉积情况。结果:与模型组相比,联合用药组的TC水平明显降低 (P<0.05);辛伐他汀组和联合用药组的LDL-C水平明显降低(P<0.05);联合用药组NO水平呈明显升高(P<0.05),且与桑白皮生物碱组和辛伐他汀组相比差异均具有统计学意义;桑白皮生物碱组、辛伐他汀组以及联合用药组均能够明显降低CRP的水平(P<0.05);联合用药能够明显降低Lp-PLA2的水平(P<0.05)。肝脏HE染色和油红O染色结果显示药物治疗后均能够改善肝脏的病变情况和脂质沉积,且联合用药组的改善情况要优于单独使用二者(P<0.05)。结论:辛伐他汀联合桑白皮生物碱给药治疗对于改善高脂血症金黄地鼠的脂质水平和炎症程度更为有效,桑白皮生物碱可以作为辛伐他汀的辅助用药,有望为临床上治疗高脂血症提供新的选择。 相似文献
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The paper aims at developing a simple two-step homogenization scheme for prediction of elastic properties of a high performance concrete (HPC) in which microstructural heterogeneities are distinguished with the help of nanoindentation. The main components of the analyzed material include blended cement, fly-ash and fine aggregate. The material heterogeneity appears on several length scales as well as porosity that is accounted for in the model. Grid nanoindentation is applied as a fundamental source of elastic properties of individual microstructural phases in which subsequent statistical evaluation and deconvolution of phase properties are employed. The multilevel porosity is evaluated from combined sources, namely mercury intrusion porosimetry and optical image analyses. Micromechanical data serve as input parameters for analytical (Mori–Tanaka) and numerical FFT-based elastic homogenizations at microscale. Both schemes give similar results and justify the isotropic character of the material. The elastic stiffness matrices are derived from individual phase properties and directly from the grid nanoindentation data with very good agreement. The second material level, which accounts for large air porosity and aggregate, is treated with analytical homogenization to predict the overall composite properties. The results are compared with macroscopic experimental measurements received from static and dynamic tests. Also here, good agreement was achieved within the experimental error, which includes microscale phase interactions in a very dense heterogeneous composite matrix. The methodology applied in this paper gives promising results for the better prediction of HPC elastic properties and for further reduction of expensive experimental works that must be, otherwise, performed on macroscopic level. 相似文献