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91.
Among the several known fatty acid‐derived chemical signals, the endogenous ligands of cannabinoid receptors type‐1 and ‐2, two G‐protein‐coupled receptors involved in several aspects of mammalian physiology and pathology, are perhaps those the levels of which have proven to be most sensitive to the fatty acid composition of the diet. The two most studied such ligands, known as endocannabinoids, are N‐arachidonoyl‐ethanolamine and 2‐archidonoylglycerol, and are found in tissues together with other N‐acyl‐ethanolamines and 2‐acylglycerols, not all of which activate the cannabinoid receptors, although several of them do exhibit important pharmacological effects. In this review article, we describe literature data indicating that the tissue concentrations of the endocannabinoids and related signalling molecules, and hence the activity of the respective receptors, can be modulated by modifying the fatty acid composition of the diet, and particularly its content in long chain PUFAs or in long chain PUFA precursors. We also discuss the potential impact of these diet‐induced changes of endocannabinoid tone on three of the major pathological conditions in which cannabinoid receptors have been involved, that is metabolic dysfunctions, inflammation and affective disorders. 相似文献
92.
Geir Kildahl-Andersen Eli Gjerlaug-Enger Frode Rise Anna Haug Bjørg Egelandsdal 《Lipids》2021,56(1):111-122
The uptake of specific fatty acids in humans is dependent on their position on the glycerol backbone. There is a great interest in methods that can access this information fast and accurately. By way of high-resolution NMR, we have analyzed TAG extracted from pig and beef tissues and obtained quantitative data for the composition and regioisomeric distribution of all major unsaturated fatty acids usually found in these source materials, using a combination of manual integration and deconvolution of 13C NMR spectra. In addition, we have developed a method for determining composition and regioisomeric distribution of the two main saturated fatty acids found in pork (16:0, 18:0). The results are discussed in relation to species-specific genetic characteristics of fatty acid and TAG biosynthesis. The developed method could support decisions related to breeding for desired fatty acid profiles, and stimulate further methodology developments using high field NMR. 相似文献
93.
Mario Kratz Paul Cullen Ursel Wahrburg 《European Journal of Lipid Science and Technology》2002,104(5):300-311
The fatty acid composition of the diet has various effects on atherosclerosis risk factors. Dietary saturated fatty acids (SFA) and trans‐unsaturated fatty acids increase the low‐density lipoprotein (LDL)‐/high‐density lipoprotein (HDL)‐cholesterol ratio in serum, while these fats do not have a significant bearing on serum triglyceride levels. By contrast, dietary monounsaturated fatty acids (MUFA), n‐6 polyunsaturated fatty acids (PUFA), and α‐linolenic acid (C18:3n‐3) similarly reduce LDL cholesterol concentrations, while their influence on serum HDL cholesterol and triglycerides is not appreciable. Dietary long‐chain n‐3 PUFA slightly increase serum LDL cholesterol concentrations, but are nevertheless considered salubrious with regard to serum lipids due to the distinct triglyceride‐lowering effects. MUFA‐rich compared to n‐6 PUFA‐rich diets strongly reduce the in vitro oxidizability of LDL. The available studies on this subject also suggest that n‐3 PUFA in the small amounts usually present in the diet are not unduly harmful. These findings are consistent with reports from observational studies: the amount of SFA is positively and the amount of MUFA and n‐6 PUFA in the diet is inversely associated with the risk of cardiovascular disease in most epidemiological studies. The available studies have had an impact on current dietary guidelines, which unanimously recommend that most of the dietary fat should be in the form of MUFA, while the amount of SFA and trans fatty acids in the diet should be as low as possible. 相似文献
94.
M. Assunta Dessì Monica Deiana Billy W. Day Antonella Rosa Sebastiano Banni Francesco P. Corongiu 《European Journal of Lipid Science and Technology》2002,104(8):506-512
The propensity of polyunsaturated fatty acids (PUFAs) to undergo oxidation plays an important role in the integrity of biological membrane and lipid containing foods. The ability of squalene (SQ), a naturally occurring dehydrotriterpene present in animal and plant tissues, to protect linoleic, linolenic, arachidonic and docosahexaenoic acids against temperature‐dependent autoxidation and UVA (ultraviolet A, 320‐380 nm) mediated oxidation was assessed. The oxidation of PUFAs was protected in varying degrees, with highest protection observed for linolenic, arachidonic and docosahexaenoic acids. Linoleic acid was less protected. At a molar ratio of 7:1 (PUFA:SQ) the inhibition of the oxidation process was 22% in the presence of linoleic acid and about 50% in presence of the other PUFAs tested. The different protection exerted by SQ against PUFAs with different degrees of unsaturation may be accounted for by the higher stability of octadecadienoic acid hydroperoxide isomers compared with respective PUFA hydroperoxides. Observing mild UVA‐mediated oxidation and the temperature‐dependent autoxidation reactions we found similarities in the oxidation pattern and the protection exerted by SQ. These findings suggest that the reaction of autoxidation is predominant and SQ acts mainly as peroxyl radical scavenger. 相似文献
95.
Schoeniger A Adolph S Fuhrmann H Schumann J 《International journal of molecular sciences》2011,12(11):7510-7528
Nutritional fatty acids are known to have an impact on membrane lipid composition of body cells, including cells of the immune system, thus providing a link between dietary fatty acid uptake, inflammation and immunity. In this study we reveal the significance of macrophage membrane lipid composition on gene expression and cytokine synthesis thereby highlighting signal transduction processes, macrophage activation as well as macrophage defense mechanisms. Using RAW264.7 macrophages as a model system, we identified polyunsaturated fatty acids (PUFA) of both the n-3 and the n-6 family to down-regulate the synthesis of: (i) the pro-inflammatory cytokines IL-1β, IL-6 and TNF-α; (ii) the co-stimulatory molecule CD86; as well as (iii) the antimicrobial polypeptide lysozyme. The action of the fatty acids partially depended on the activation status of the macrophages. It is particularly important to note that the anti-inflammatory action of the PUFA could also be seen in case of infection of RAW264.7 with viable microorganisms of the genera R. equi and P. aeruginosa. In summary, our data provide strong evidence that PUFA from both the n-3 and the n-6 family down-regulate inflammation processes in context of chronic infections caused by persistent pathogens. 相似文献
96.
Arnar?Halldorsson Gudmundur?G.?HaraldssonEmail author 《Journal of the American Oil Chemists' Society》2004,81(4):347-353
The objective of the work described in this paper was to study a possible FA selectivity of digestive lipolytic enzymes isolated
from salmon and trout intestines toward astaxanthin diesters of various FA composition and compare it with the FA selectivity
of microbial lipase. Astaxanthin diesters of varying FA composition were prepared in excellent yields (>90%) by chemical esterification
using a carbodiimide coupling aget. The astaxanthin diesters were screened in a hydrolysis reaction by various commercially
available lipases. The highest conversion rates were observed with the Candida rugosa lipase, which discriminated against n−3 PUFA. The rate of hydrolysis was determined by HPLC. Digestive lipolytic enzymes
isolated from salmon and rainbow trout intestines displayed reversed FA selectivity. Thus, astaxanthin diesters highly enriched
with n−3 PUFA including EPA and DHA were observed to be hydrolyzed at a considerably higher rate than the more saturated esters.
Similar trends in FA selectivity were observed in the hydrolysis of fish oil TAG by the digestive lipolytic enzyme mixtures. 相似文献
97.
Investigating Fatty Acid Composition of Samples were Homogenized Various Meat and Offal Products from Turkey 下载免费PDF全文
Levent Coskuntuna Umit Gecgel Ismail Yilmaz Unal Gecgel Gizem Cagla Dulger 《Journal of the American Oil Chemists' Society》2015,92(5):659-665
The aim of the present study was to compare the fatty acid composition, PUFA:SFA ratio, n6/n3 ratio, and TFA of different farm animal meats and offal products. These products were collected at a regional farm in Istanbul which is the most populous city in Turkey. The results of fatty acid composition analysis indicated that the major fatty acids of C16:0 (18.00–29.35 %), C18:0 (4.10–29.71 %), C18:1 (29.21–57.30 %), and C18:2 (1.37–18.60 %) were found in the samples. The total saturated fatty acids, total monounsaturated fatty acids and total polyunsaturated fatty acids content of the samples ranged between 30.00 and 61.83 %, 32.24 and 57.80 %, and 1.64 and 23.60 %, respectively (p < 0.05). Except for turkey abdominal fat, TFA content in all other samples showed a variation between 0.10 and 3.36 %. The PUFA:SFA ratio was higher in turkey meat (0.64) and was lower in sheep kidney fat (0.02). Moreover, the n6/n3 PUFA ratio changed between 2.90 and 22.28 (p < 0.05). 相似文献
98.
Synthesis of polyunsaturated fatty acid-enriched triglycerides by lipase-catalyzed esterification 总被引:2,自引:0,他引:2
L. Esteban Cerdán A. Robles Medina A. Giménez Giménez M. J. Ibáñez González E. Molina Grima 《Journal of the American Oil Chemists' Society》1998,75(10):1329-1337
This paper reports on the synthesis of triglycerides by enzymatic esterification of polyunsaturated fatty acids (PUFA) with
glycerol. A PUFA concentrate obtained from cod liver oil was used to optimize the reaction to favor triglyceride synthesis
with lipases. The type and amount of lipase and organic solvent, glycerol content, temperature, water content, and amount
and time of addition of molecular sieves were studied. The optimal reaction mixture and conditions were: 9 mL hexane, 60°C,
0.5% (vol/vol) water, 1 g molecular sieves added after 24 h of reaction, glycerol/fatty acid molar ratio 1:3 and 100 mg of
Novozym 435 (Novo Nordisk A/S) lipase. Under these conditions, an enriched triglyceride yiedl of 84.7% containing 27.4% eicosapentaenoic
acid and 45.1% docosahexaenoic acid was obtained from a cod liver oil PUFA concentrate. 相似文献
99.
White Bass (<Emphasis Type="Italic">Morone chrysops</Emphasis>) Preferentially Retain n-3 PUFA in Ova When Fed Prepared Diets with Varying FA Content 下载免费PDF全文
S.?Adam?FullerEmail author Steven?D.?Rawles Matthew?E.?McEntire Troy?J.?Bader Marty?Riche Benjamin?H.?Beck Carl?D.?Webster 《Lipids》2017,52(10):823-836
We evaluated the fatty acid (FA) composition of broodstock white bass ova fed one of six commercial diets with increasing polyunsaturated FA content (n‐6/n‐3 ratio; 0.36, 0.39, 0.46, 0.83, 1.07, 1.12) eight weeks prior to sampling. Fatty acid profiles of ova from brooders fed each of the six diets were significantly altered according to canonical discriminant analysis. Ova FA profiles resulting from the 0.39 diet separated those from the 0.36 diet based on lower 18:2n‐6 (LNA) and higher 20:1n‐9 concentrations from the 0.36 diet. Ova profiles were further separated based on lower concentrations of 22:5n‐3 (DPA) from the 0.46 diet, lower concentrations of 20:5n‐3 (EPA) in the 1.12 and 0.83 diets, and lower concentrations of 22:6n‐3 (DHA) in all other diets relative to the 0.46 diet. Changes in ova FA profile at four and eight weeks were consistent with dietary intake with an approximate 2% increase in any given FA class with increasing time on individual diet. There was no correlation between dietary ARA concentrations (0.7–1.1 mol%), or dietary EPA/ARA ratios (7–15), and the concentrations (1.4–1.7 mol%) or ratios (3.3–4.4) found in the ova by diet. Our results suggest that white bass females have the ability to preferentially incorporate n‐3 PUFA, particularly DHA, suggesting mobilization of this FA from other tissues for ova deposition or preferential dietary incorporation of PUFA into ova. These results will add to the limited FA information available in white bass and enable nutritionists to formulate broodstock diets that maximize reproductive potential in this species. 相似文献
100.
Microencapsulation of fish oil by spray drying--impact on oxidative stability. Part 1 总被引:3,自引:1,他引:2
Wojciech Kolanowski Maciej Ziolkowski Jenny Weißbrodt Benno Kunz Günther Laufenberg 《European Food Research and Technology》2006,222(3-4):336-342
The aim of this study was to investigate the influence of spray drying on oxidative stability of dried microencapsulated fish
oil (DMFO) coated with modified cellulose. DMFO samples were obtained by spray drying of prepared emulsions consisted of water
solution of modified cellulose and fish oil. Appearance and size of particles were measured by electron microscopy and laser
light microsizer. The oxidative stability of samples was evaluated by peroxide value measurements. Additionally the influence
of different antioxidant substances on oxidative stability of the fish oil was investigated. It was observed that oxidation
changes were much slower in bulk fish oil compared to DMFO. The most important factor determining shelf-life of the product
was the access to air. It can be concluded, that the production of fish oil microcapsules by spray drying technique is possible,
however its oxidative stability is not improved. 相似文献