Since the introduction of warranty provisions in federal highway jobs, more and more state departments of transportation (DOTs) have considered the use of such provisions to protect their initial investment. This paper describes the pros and cons of warranty contracting in highway construction based on a survey of warranty practices in the United States. In particular, the need for state DOTs to buy a warranty for a well-built project is questioned. As an alternative, this paper introduces the warranty option, which gives the DOT the right to buy a warranty only if it becomes necessary at the end of construction. This option is exercised if the performance on site warrants it. This paper describes the mechanics of the warranty option and its advantages over the conventional warranty. A bid evaluation model is also developed for the warranty option approach. 相似文献
At the same time that state departments of transportation are allowing contractor-performed quality control, they are also concerned about using the contractor-reported data for acceptance and payment purposes. The question is, are we putting the fox in charge of guarding the chickens? To address this concern, a large number of asphalt and concrete projects in Kentucky were examined. The statistical analyses showed that for the most part there is no significant difference between the contractor-performed acceptance data and concomitant highway agency-performed verification data. This is obviously a very encouraging finding that is expected to enhance the level of trust between the contractors and highway agencies. 相似文献
Factors influencing the direct transformation of the yeast Saccharomyces cerevisiae with synthetic oligonucleotides were investigated by selecting for cyc1 transformants that contained at least partially functional iso-1-cytochrome c. Approximately 3 x 10(4) transformants, constituting 0.1% of the cells, were obtained by using 1 mg of oligonucleotide in the reaction mixture. Carrier, such as heterogeneous oligonucleotides, enhanced transformation frequencies. Transformation frequencies were dramatically reduced if the oligonucleotides had a large number of mismatches or had terminally located mismatches. Transformation with oligonucleotides, but not with linearized double-strand plasmid, was efficient in a rad52- strain, suggesting that the pathway for transformation with oligonucleotides is different from that with linearized double-strand plasmid. We describe a procedure of co-transformation with two oligonucleotides, one correcting the cyc1 defect of the target allele in the host strain, and the other producing a desired amino acid alteration elsewhere in the iso-1-cytochrome c molecule; approximately 20% of the transformants obtained by co-transformation contained these desired second alterations. 相似文献
Today’s engineering managers who use total quality management (TQM) face the challenge of moving it from adoption to seamless incorporation into their organizations. Both the application and the theory of TQM can be advanced through an examination of the philosophy of pragmatism and the sciences of adaptation. Pragmatism provides a philosophy that establishes a theory for incorporating TQM into engineers’ management practice; it derives its epistemology from actual experience. In essence, pragmatism suggests that practical experience, such as that gained from the continuous improvement of and experimentation with TQM, provides the basis for successful organizational performance. The sciences of adaptation identify the characteristics of organizations that promote successful adaptation. They suggest that incremental adjustments to ongoing change are the keys to effective and successful growth. This paper explores both philosophy and science to identify actions and attitudes that can enable the success of TQM in an organization. 相似文献
Biochips are miniaturized, highly ordered analysis systems which offer the unique advantage of highly parallel analysis of thousands of analytes at the same time. Although this technique has been enthusiastically developed and has promised to improve and speed up numerous biological assays, the quality control of chip manufacture, chip analysis and data management has received less attention.
The following article compares three epoxy-containing chip surfaces (ARChip Epoxy, 3D-Link™, and EasySpot) with respect to their autofluorescence, immobilization capacity, background fluorescence and hybridization efficiency. Since data collected from biochip experiments are random snapshots with errors, inherently noisy and incomplete, we tried to evaluate technical factors causing variability and to set up quality control procedures for chip manufacture and chip analysis. Variabilities caused by arraying, glass substrate and polymer coating, fluorescent label and experimental conditions are discussed in details. 相似文献