AlCl3-Catalyzed Directional Conversion of some Polycyclic Aromatics

1　 IntroductionIt is well known that coal is the main fossilresource and energy,butit is also the main pollu-tion source in the world. The conventional meth-ods of coal utilization such as combustion,car-bonization,liquefaction and gasification can ob-tain only fuel and other low value products.Allthese conversion processes of coal belong to fuelutilization. L arge amounts of dust,SOx,CO2 andNOx,which cause the environment to be worseand worse,are emitted due to the processes. Be-cause of …     

Concave reagents. 31. A Merrifield bound concave pyridine for the selective acylation of polyols

The concave pyridine 2a has been synthesized in 61% yield in two macrocyclization steps. After deprotection to give 2b , the concave pyridine has been attached to a Merrifield resin, and the resulting polymer 10 containing 0.3 mmol 2 /g has been used as a selective acylation catalyst for the addition of propane‐1,2‐diol ( 11 ) and the glucose derivative 14a to diphenylketene ( 12 ) to form selectively 2‐hydroxypropyl diphenylacetate ( 13a ) (selectivity 13a / 13b : 11:1) and methyl 4,6‐0‐benzylidene‐2‐diphenylacetyl‐α‐D‐gluco‐pyranoside ( 14b ), (selectivity 14b / 13c : 29:1), respectively. After successful applications in batch reactions, the selective addition of 11 to 12 has also been carried out in a flow reactor filled with the polymeric catalyst 10 .     

Synthesis and chemical modification of new epoxy resins containing alkylaminopyridines

A new series of epoxy resins containing 4‐(N,N‐dialkylamine)pyridines (DAAP) functionality was prepared by reaction of 4‐aminopyridine or/and aniline with epichlorohydrin. Then, hydroxyl groups in the polymeric chain underwent a chemical modification with acyl chloride. Modification of the side group and backbone of the chain resulted in an enhancement of solubility of the linear catalyst with catalyzed system and also led to an accelerated acylation. Here, acetylation of tert‐butyl alcohol was monitored by means of chromatographic analyses for determining the catalytic power of these polymeric catalysts. Catalytic activity of the modified linear poly(4‐aminopyridine‐epichlorohydrin‐aniline) was found to be more effective than that of DMAP, and catalytic activity of network polymers in a heterogeneous system was found to be somewhat lower than that of any of its linear analogs. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 71: 1101–1105, 1999     

Erbium(III) Triflate as an Extremely Active Acylation Catalyst

Erbium(III) triflate is a powerful catalyst for the acylation of alcohols and phenols. The reaction works well for a large variety of simple and functionalized substrates by using different kinds of acidic anhydrides {Ac₂O, (EtCO)₂O, [(CH₃)₃CO]₂O, Bz₂O, and (CF₃CO)₂O} without isomerisation of chiral centres. Moreover, the catalyst can be easily recycled and reused without significant loss of activity.     

Free Radical‐Mediated Acylation and Carboxylation Reactions

Radical acylations to prepare carbonyl compounds are described and focus on indirect acylation approaches using sulfonyl oxime ethers under tin‐mediated and tin‐free conditions. The efficiency of carboxylic acid derivatives as carbonyl group radical acceptors in radical acylation and carboxylation reactions is discussed.     

酰化和酶法修饰后牦牛乳酪蛋白热稳定性变化

采用酰化试剂和转谷氨酰胺酶(TG)对牦牛乳中的酪蛋白进行改性,并对改性后的酪蛋白进行热稳定性研究,通过在280nm处测定吸光度值来评价酪蛋白热稳定性。结果表明,酪蛋白经TG交联后热稳定性提高。采用不同酰化试剂修饰后,牦牛乳酪蛋白热稳定性增强,不同改性修饰的酪蛋白热稳定性差异较大,琥珀酸酐修饰酪蛋白热稳定性最强。结果可为牦牛乳酪蛋白修饰和产品开发及利用提供参考依据。      

邻硝基对甲苯胺的合成

综述了标题化合物的合成方法。以对甲苯胺为原料时，可用多种方法如苯磺酰氯、醋酐、光气等将氨基保护后硝化；以对甲苯氨基甲酸甲酯为原料时，硝化后用碱性水解，收率94％：也可以3-硝基-4-氯甲苯为原料经氨解而成。     

头孢拉定生产工艺和设备的改进

简要介绍了对头孢拉定生产工艺和设备的改进及所取得的效益。     

Application of immobilized lipase in production of camptosar (CPT-11)

Lipase fromPseudomonas cepaica (Amano, PS-30) was immobilized on celite and used in organic solvent for the selective acylation of a key alcohol intermediate. The compound was transformed in the synthesis to the anticancer drug Camptosar (CPT-11). Catalyst activity was influenced by the water content and method used to dry the catalyst. This resolution has been conducted on production scale with equal weight of recyclable catalyst.     

离子液体在Friedel-Crafts反应中的应用

综述了离子液体中的Friedel-Crafts酰基化和烷基化反应。