Dynamic Modelling and Prediction of Cytotoxicity on Microelectronic cell Sensor Array

A real‐time cell electronic sensing (RT‐CES) system has been used for label‐free dynamic measurements of cell responses to toxicant. Cells are grown onto the surfaces of the microelectronic sensors. Changes in cell number expressed as cell index (CI) have been recorded on‐line as time series. The CI data are used for dynamic modelling or parameter estimation for cell cytotoxicity process. We consider two dynamic modelling approaches, namely data‐based system identification and first principle modelling. It is shown that data‐based system identification can provide a quick solution for the cytotoxicity dynamic models and is effective for short‐term predictions. It, however, can be poor for long‐term predictions, particularly if there is no output correction, i.e., when the model is used for simulation. In view of this, the first principle modelling approach by considering fundamental physical principles such as toxicant transport is explored. For long‐term prediction or simulation, the prediction performance for some of cytotoxicity process is dramatically improved using the models obtained from the latter approach. This happens only if the underlying mechanism is truly understood. Through several cytotoxicity modelling and validation studies, it is shown that the black box modelling and first principle modelling both should be considered in challenging modelling problems such as the cytotoxicity. Pros and cons of the two modelling approaches are discussed.     

利用测井资料识别碳酸盐岩裂缝的方法

在碳酸盐岩地层中,裂缝是非常常见且十分重要的一类储集空间类型,对油气的运移和聚集有非常重要的作用。因此,裂缝的识别显得特别重要。本文以新疆某油田为例,通过岩芯观察及成像测井资料与常规测井资料进行比对,总结出了不同类型裂缝对常规测井的不同响应特征。通过实际应用,识别效果良好,证明用测井方法识别不同类型的裂缝是可行的。     

基于信道识别的WPM解调性能改善研究

小波包调制的主要优势是其调制结构以及解调策略上的灵活性。该文利用小波包调制多速率传输特性,通过信道识别,采用联合估计的方法,探讨了小波包调制系统在不同信道中的性能改善问题。仿真结果表明该方法明显提高了小波包调制系统在不同信道中的传输性能以及抗干扰能力。     

基于模块化模型的自适应预失真技术

系统地比较和分析了OFDM传输系统里高功率放大器（HPA）预失真方法的优缺点,提出一种基于模块化模型的有记忆高功率放大器自适应数字预失真方法,该方法分别基于Wiener、Hammerstein和Wiener-Hammerstein模型各自构成一个有记忆HPA的自适应预失真器。从而避免了因分别估计Wiener-Hammerstein模型各个环节特性参数所带来的复杂性。使得有记忆高功率放大器的预失真设计变得简单了。     

基于图像噪声分析的计算机生成图像检测算法

计算机生成图像与自然图像在物理生成机理上的差异性导致其在噪声分布上具有明显的区别,据此提出一种基于图像噪声分析的计算机生成图像检测新方法。首先,用小波隐马尔可夫(MMT)模型对图像噪声进行预处理;接着,基于最大似然估计方法估测图像参考模式噪声;最后,在提取图像模式噪声统计距及其与参考模式噪声相关差值基础上,利用支持向量机(SVM)分类器进行鉴别。实验结果显示,较已有的典型算法,该算法具有更好的检测率。     

6-PRRS并联机器人的动力学建模研究

为解决并联机器人动力学模型的计算复杂性与实时准确控制之间的矛盾,采用虚功原理建立6-PRRS并联机器人各构件随参数变化的完整动力学方程,对6-PRRS并联机器人动力学模型在各种工作情况下进行仿真分析,对机器人各部分质量和转动惯量对驱动力的影响进行研究,提出动力学模型简化策略,减小了动力学计算量,提高并联机器人动力学的计算速度,为并联机器人的控制和参数识别奠定了基础.     

基于Morlet小波变换和改进遗传算法的动态识别

如何合理地识别大型复杂结构的动力参数一直是工程领域关心的问题.为此,以Morlet小波变换和采用单亲遗传算子的改进遗传算法为基础,构造一结构动态参数识别模型.并且以C++为平台,通过计算机内部命令调用ANSYS等软件,实现识别模型的程序化.通过模拟算例计算,计算结果与理论值一致.同时,结合一水电站厂房现场振动试验,对该大型结构进行动态参数识别,识别结果与工程经验值基本吻合.     

结构损伤识别的残余向量法及数值仿真

为了找到对小损伤较敏感的参数,在结构自由振动微分方程基础上,利用广义逆和矩阵投影定理,导出了识别效果很好的残余向量投影范数.确定了损伤单元,计算了该损伤单元的损伤因子.算例分析发现,该参数对结构损伤非常敏感,能识别出结构中的微小损伤,而且不受损伤位置的约束,仅需要结构的前几阶模态就能达到很好的效果.     

内模原理在转台波动力矩抑制中的应用

为了消除系统存在的周期性扰动特别是干扰力矩对系统速率平稳性能的影响,本文对基于内模原理的自适应周期性扰动抑制方法进行了研究,利用该控制策略能够较好的抑制含单一频率、多种频率和时变频率的周期性扰动.并且对扰动频率变化较快时频率估计中出现的波动现象进行了分析.该方法在测试转台模型上进行了仿真,仿真结果显示出了良好的扰动频率辨识能力和对扰动的抑制能力.     

Similarity identification method on formational interfaces and application in general granite

An instrumented drilling system can be applied for the acquisition of drilling process parameters.The system can provide continuous and huge data for geotechnical engineering.However, due to the complexity of ground strata, the variation in the drilling parameters with stratigraphical characteristics is great and the correlation between likely comparable parameters is not high, which limits the use of conventional correlation approaches in this field.How to use the data for engineering and how to get a reasonable interpretation for the relationships among the drilling parameters, as well as between a drilling parameter and formational character-istics, become a technical choke point for the development and application of the instrumented drilling system.Based on similarity criteria, the extraction of sample data and characteristics, the pretreatment of data and feature matching algorithms have been ana-lyzed and an approach of slope coefficient searching identification has been established.A case study was carried out for the similar-ity between the rotational speed of the drill bit, flushing pressure, and effective thrust force graphics in general weathered granite.The result shows that the similarity coefficients between the rotational speed of the drill bit, flushing pressure, and effective thrust force are 0.72 and 0.83, respectively.Although there are differences between the distances of the graphics, the curves of both rota- tional speed and flushing pressure agree with the effective thrust curve in shape, which provides a possible method for the identifica- tion of various formations by use of the similarity between feature drilling parameters.