Ivabradine Induces Cardiac Protection against Myocardial Infarction by Preventing Cyclophilin-A Secretion in Pigs under Coronary Ischemia/Reperfusion

In response to cardiac ischemia/reperfusion, proteolysis mediated by extracellular matrix metalloproteinase inducer (EMMPRIN) and its secreted ligand cyclophilin-A (CyPA) significantly contributes to cardiac injury and necrosis. Here, we aimed to investigate if, in addition to the effect on the funny current (I(f)), Ivabradine may also play a role against cardiac necrosis by reducing EMMPRIN/CyPA-mediated cardiac inflammation. In a porcine model of cardiac ischemia/reperfusion (IR), we found that administration of 0.3 mg/kg Ivabradine significantly improved cardiac function and reduced cardiac necrosis by day 7 after IR, detecting a significant increase in cardiac CyPA in the necrotic compared to the risk areas, which was inversely correlated with the levels of circulating CyPA detected in plasma samples from the same subjects. In testing whether Ivabradine may regulate the levels of CyPA, no changes in tissue CyPA were found in healthy pigs treated with 0.3 mg/kg Ivabradine, but interestingly, when analyzing the complex EMMPRIN/CyPA, rather high glycosylated EMMPRIN, which is required for EMMPRIN-mediated matrix metalloproteinase (MMP) activation and increased CyPA bonding to low-glycosylated forms of EMMPRIN were detected by day 7 after IR in pigs treated with Ivabradine. To study the mechanism by which Ivabradine may prevent secretion of CyPA, we first found that Ivabradine was time-dependent in inhibiting co-localization of CyPA with the granule exocytosis marker vesicle-associated membrane protein 1 (VAMP1). However, Ivabradine had no effect on mRNA expression nor in the proteasome and lysosome degradation of CyPA. In conclusion, our results point toward CyPA, its ligand EMMPRIN, and the complex CyPA/EMMPRIN as important targets of Ivabradine in cardiac protection against IR.     

Effective DOA Estimation Under Low Signal-to-Noise Ratio Based on Multi-Source Information Meta Fusion

Efficiently performing high-resolution direction of arrival (DOA) estimation under low signal-to-noise ratio (SNR) conditions has always been a challenge task in the literatures. Obvi-ously, in order to address this problem, the key is how to mine or reveal as much DOA related in-formation as possible from the degraded array outputs. However, it is certain that there is no per-fect solution for low SNR DOA estimation designed in the way of winner-takes-all. Therefore, this paper proposes to explore in depth the complementary DOA related information that exists in spa-tial spectrums acquired by different basic DOA estimators. Specifically, these basic spatial spec-trums are employed as the input of multi-source information fusion model. And the multi-source in-formation fusion model is composed of three heterogeneous meta learning machines, namely neural networks (NN), support vector machine (SVM), and random forests (RF). The final meta-spec-trum can be obtained by performing a final decision-making method. Experimental results illus-trate that the proposed information fusion based DOA estimation method can really make full use of the complementary information in the spatial spectrums obtained by different basic DOA estim-ators. Even under low SNR conditions, promising DOA estimation performance can be achieved.     

V2O5/g⁃C3N4催化剂的制备及其模拟油中硫化物的脱除

以三聚氰胺、偏钒酸铵、硼酸为前驱体,通过煅烧法制备V₂O₅/g⁃C₃N₄催化剂。采用XRD、FT⁃IR、XPS、SEM和BET等技术对催化剂的结构与形貌进行表征。以V₂O₅/g⁃C₃N₄为催化剂,乙腈为萃取剂,H₂O₂为氧化剂对模拟油中二苯并噻吩（DBT）的脱除进行考察。探究了反应温度、催化剂质量、萃取剂体积、n(H₂O₂)/n(S)以及不同硫化物等因素对脱硫效果的影响。在模拟油体积为5.0 mL、萃取剂乙腈体积为3.0 mL、n(H₂O₂)/n(S)=8、催化剂质量为0.02 g、反应温度为30 ℃和反应时间为60 min的最佳条件下,DBT的脱除率达到91.9%,经过5次催化剂再生后脱硫率仍可以达到85.7%。     

煤层注气强化开采流固耦合效应研究

为准确表征煤层气藏强化开采过程中的复杂地质力学效应,同时考虑多孔介质全组份多过程物质运移特征,构建了煤层气藏强化开采全流固耦合数学模型,开发了相应的数值模拟算法,并据此进一步剖析了地质力学效应以及注入气组成对孔渗参数及注采指标的影响。结果表明,有效应力效应与基质膨胀/收缩作用均可显著地影响孔隙度与渗透率,但两者作用方向相反,注入CO2诱发的基质膨胀可使注入井附近渗透率损失近90%。随着杨氏模量的增大或者基质形变强度的降低,CO2突破时间提前,导致煤层气产量及CO2埋存量降低。研究成果可为煤层气产能准确预测及高效开发提供技术支持。     

不同基质配比对银毛野牡丹扦插的影响

银毛野牡丹是优良的园林观赏性植物,但是繁殖有性结实率低。通过为期30天的扦插试验,对比不同基质（原土、草炭土、蛭石、珍珠岩）配比对银毛野牡丹插穗生长的影响,分析插穗生根时间、生根数目、最长根长、生根率、生长状态以及基质变化,找出适合其生长发育的优良基质,为银毛野牡丹的繁殖提供技术支撑。研究表明：试验组T8（原土：细沙：草炭土：蛭石：珍珠岩=1：1：2：1：1）的插穗生根率、最长根长、插穗长势为最佳,试验组T2（草炭土）效果次之,在条件有限的情况下可以作为备用方案以供生产所需。     

多小区多播无线携能通信鲁棒信干噪比平衡

针对非理想信道多小区多播协作网络中的供能问题,提出了一种鲁棒的无线携能通信优化方案,该方案以最差用户信干噪比最大化为目标、以每用户能量采集和每小区功率为约束,在保证用户能量采集约束和系统功率预算的前提下实现最差用户服务质量最优化.为了求解优化问题,采用半定松弛和S-引理将原始问题转化为拟凸优化问题,进而采用二分迭代算法得到问题的最优解.仿真结果表明,所提系统设计正确,迭代算法收敛特性良好.     

单关节机器人伺服系统的建模与仿真

为了深入研究机器人驱动系统,需要进行单关节机器人伺服系统的建模与仿真。首先对单关节机器人的规划轨迹、机械结构、电气结构和控制器分别建立数学模型;然后根据数学模型在MATLAB/Simulink平台上搭建伺服系统的仿真模型;最后对仿真结果做了分析,为机器人系统的优化设计与调试提供了有效模型和依据。     

短开路耦合谐振器加载的宽带带通滤波电路

提出了一种基于短开路耦合器加载的宽带带通滤波电路. 该滤波电路通过在输入和输出端口之间,并连加载短路耦合微带谐振器和开路耦合微带谐振器实现5个传输极点和3个传输零点的带通选择特性. 对所提出的短开路耦合谐振器进行了奇偶模理论分析,揭示了其传输零极点形成的物理机理. 最后,对所提出的滤波电路进行了加工测试. 测试结果表明,所提出的宽带滤波电路能够在2.0～4.2 GHz频率范围内实现 3 dB 带通传输,工作相对带宽为73%,仿真和实测结果吻合较好.     

汽车铝合金阀盖压力铸造模具数字设计与制造

制造过程实质上是信息采集、传输、处理及应用的过程.将制造信息数字化,用数字信息驱动制造系统完成造物的过程称为数字制造.数字制造不仅能提高制造效率而且能显著降低制造成本.本文以汽车制动系阀盖为例介绍了基于Pro/E的压力铸造模具的开发过程,分析了压力铸造模具数字设计与制造的特点.     

Study on diffusion welding SiCp/ZL101 with Cu interlayer

Through the vacuum diffusion welding SiCp/ZL101 aluminum with Cu interlayer,the effect of welding parame-ter and the thickness of Cu on the welded joint property was investigated,and the optimal welding parameters were putforward at the same time.The microstructure of joint was analyzed by means of optical-microscope,scanning electron mi-croscope in order to study the relationship between the macro-properties of joint and the microstructure.The results showthat diffusion welding with Cu interlayer could be used for welding aluminum matrix composites SiCp/ZL101 successfully.