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Kecheng Quan Zexin Zhang Hong Chen Xiaoxiang Ren Yijin Ren Brandon W. Peterson Henny C. van der Mei Henk J. Busscher 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(39)
The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms to enhance antimicrobial penetration and bacterial killing is proposed. Staphylococcus aureus biofilms are exposed to magnetic‐iron‐oxide nanoparticles (MIONPs), while magnetically forcing MIONP movement through the biofilm. Confocal laser scanning microscopy demonstrates artificial channel digging perpendicular to the substratum surface. Artificial channel digging significantly (4–6‐fold) enhances biofilm penetration and bacterial killing efficacy by gentamicin in two S. aureus strains with and without the ability to produce extracellular polymeric substances. Herewith, this work provides a simple, new, and easy way to enhance the eradication of infectious biofilms using MIONPs combined with clinically applied antibiotic therapies. 相似文献
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Yang Song Usha Kadiyala Priyan Weerappuli Jordan J. Valdez Srilakshmi Yalavarthi Cameron Louttit Jason S. Knight James J. Moon David S. Weiss J. Scott VanEpps Shuichi Takayama 《Advanced materials (Deerfield Beach, Fla.)》2019,31(14)
Neutrophil extracellular traps (NETs) are decondensed chromatin networks released by neutrophils that can trap and kill pathogens but can also paradoxically promote biofilms. The mechanism of NET functions remains ambiguous, at least in part, due to their complex and variable compositions. To unravel the antimicrobial performance of NETs, a minimalistic NET‐like synthetic structure, termed “microwebs,” is produced by the sonochemical complexation of DNA and histone. The prepared microwebs have structural similarity to NETs at the nanometer to micrometer dimensions but with well‐defined molecular compositions. Microwebs prepared with different DNA to histone ratios show that microwebs trap pathogenic Escherichia coli in a manner similar to NETs when the zeta potential of the microwebs is positive. The DNA nanofiber networks and the bactericidal histone constituting the microwebs inhibit the growth of E. coli. Moreover, microwebs work synergistically with colistin sulfate, a common and a last‐resort antibiotic, by targeting the cell envelope of pathogenic bacteria. The synthesis of microwebs enables mechanistic studies not possible with NETs, and it opens new possibilities for constructing biomimetic bacterial microenvironments to better understand and predict physiological pathogen responses. 相似文献
64.
Xiaojia Zhao Qun Li Pradip Pachfule Zhiya Wang Shiyin Liu Weijian Wu Mingxing Wu Arne Thomas 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(26):2301200
Techniques beyond crystal engineering are critical for manufacturing covalent organic frameworks (COFs) and to explore them for advanced applications. However, COFs are normally obtained as insoluble, unmeltable, and thus nonprocessible microcrystalline powders. Therefore, it is a significant challenge to implement COFs into larger architectures and structural control on different length scales. Herein, a facile strategy is presented to prepare flexible COF nanofiber membranes by in-situ growth of COFs on polyacrylonitrile (PAN) nanofiber substrates via a reversible polycondensation-termination approach. The obtained PAN@COF nanofiber membranes with vertically aligned COF nanoplates combine a large functional surface with efficient mass transport, thus making it a promising adsorbent, for example, for water purification. The antibiotic pollutant ofloxacin (OFX) is removed from water with a superior absorption capacity of ≈236 mg g−1 and removal efficiency as high as 98%. The here presented in-situ growth of COFs on nanofiber membranes can be extended to various Schiff base-derived COF materials with different compositions, providing a highly efficient way to construct flexible COF-based membranes for several applications. 相似文献
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介绍了纳米材料在抗菌塑料中应用的优点。综述了纳米TiO2抗菌塑料及其制品的发展状况。报道了近年来单一树脂基体和多种树脂基体的纳米TiO2抗菌塑料的研究和开发成果;纳米TiO2抗菌塑料制品的有报道的成果集中在塑料薄膜。 相似文献
66.
ABSTRACTThe efficacies of UV photolysis, UV-activated persulfate (UV/PS), and combined UV/Fe2+-activated persulfate (UV/PS/Fe2+) systems for degrading of different organic micropollutants in ultrapure water and groundwater were examined and compared. The studied micropollutants belonging to the different classes involved an artificial sweetener acesulfame K (ACE), beta-lactam antibiotic amoxicillin (AMX), and endocrine disrupting compound 4-nonylphenol (NP). Among the studied systems, the UV/PS/Fe2+ process showed the highest performance both in degradation and in mineralization of ACE (UVA-induced systems; kapp = 0.126 1/min and 80.3% TOC removal) and AMX (UVC-induced systems; kapp = 1.383 1/min and 85.4% TOC removal), followed by the UV/PS process. In the case of NP trials, the application of UVC/PS systems was the most promising, and after careful adjustment of oxidant concentration, it demonstrated a considerable improvement in the target compound degradation (at a NP/PS molar ratio of 1/4 kapp = 0.024 1/min) compared with the UVC photolysis (kapp = 0.016 1/min). Irrespective of the applied UV-induced treatment process, the efficacy of target compounds degradation was lower in groundwater as compared with ultrapure water trials. 相似文献
67.
李英 《华北水利水电学院学报》2011,(6):148-150
采用气浮-生物-臭氧气浮联合工艺对抗生素生产废水进行处理,研究了该工艺对废水化学需氧量(COD)的去除效果.结果表明,当进水的COD在8 000 mg/L左右时,出水的COD小于200 mg/L,处理效果可达97.5%以上. 相似文献
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Man Ying Jia Zhuang Xiaoli Wei Xinxin Zhang Yue Zhang Yao Jiang Diana Dehaini Mengchun Chen Silun Gu Weiwei Gao Weiyue Lu Ronnie H. Fang Liangfang Zhang 《Advanced functional materials》2018,28(22)
The recent emergence of biomimetic nanotechnology has facilitated the development of next‐generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, this study reports on the remote loading of small molecule therapeutics into cholesterol‐enriched platelet membrane‐derived vesicles for disease‐targeted delivery. Using this approach, high loading yields for two model drugs, doxorubicin and vancomycin, are achieved. Leveraging the surface markers found on platelet membranes, the resultant nanoformulations demonstrate natural affinity toward both breast cancer cells and methicillin‐resistant Staphylococcus aureus. In vivo, this translates to improved disease targeting, increasing the potency of the encapsulated drug payloads compared with free drugs and the corresponding nontargeted nanoformulations. Overall, this work demonstrates that the remote loading of drugs into functional platelet membrane‐derived vesicles is a facile means of fabricating targeted nanoformulations, an approach that can be easily generalized to other cell types in the future. 相似文献
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