部分填充手征负折射率介质的平行板波导

部分填充手征负折射率介质的平行板波导中电磁波传输的导模特性进行了研究,给出了导模的场分布公式,推导出导模的特征方程.数值计算了导模的色散特性曲线、功率曲线和能流分布,探讨了手征负折射率介质层的厚度、手征参数等对导模特性的影响,发现了导模的一些奇异特性,如存在表面波模、功率流动方向与相位传播方向相反的后向波、功率储存、传播常数三值、模式交叉等现象,还发现此波导中存在电磁波传播的禁带.     

一种手性抗惊厥药物普瑞巴林的合成方法

简述和分析了普瑞巴林的主要合成方法,以丙二酸酯和异戊醛为原料的路线消耗低、反应条件温和而具有实用价值.     

The influence of chirality,physicochemical properties,and permeation enhancers on the transdermal permeation of amlodipine across rat skin

Purpose: This study was aimed at investigating the possible relationship between the physical properties and the permeation of S-amlodipine and RS-amlodipine and studying the possible enantioselectivity of permeation of amlodipine in the presence and absence of enhancers, such as terpene enhancers and ethanol. Method: The solubility of S-amlodipine and RS-amlodipine was measured using the shake-flask method. The thermodynamic properties were investigated by differential scanning calorimetry (DSC). The type of racemate amlodipine was investigated by DSC and Fourier transform infrared spectroscopy (FTIR). The permeability of racemate and enantiomers of amlodipine through rat epidermis in vitro was investigated using the modified Franz diffusion cell. Results: The aqueous solubility of S-amlodipine was higher than that of RS-amlodipine. The melting temperature and enthalpy of fusion of S-amlodipine were lower than those of RS-amlodipine. RS-amlodipine was a racemic compound. The permeation of the enantiomers of amlodipine from RS-amlodipine reservoir showed no significant differences in the presence and absence of enhancers, but the permeation of S-amlodipine from S-amlodipine reservoir was significantly higher than that of RS-amlodipine from RS-amlodipine reservoir 30% ethanol, 50% ethanol, and terpene enhancers could not influence the difference in permeation between S-amlodipine and RS-amlodipine, but 75% ethanol could reduce the difference. Conclusion: These results suggested that there was no enantioselectivity of the enantiomers of amlodipine from RS-amlodipine reservoir in the presence and absence of enhancers, but the differences in physical properties between S-amlodipine and RS-amlodipine led to the difference in permeation across rat skins.     

手性噁唑啉配体及其在不对称催化反应中的应用

综述了各种手性恶唑配体及其在不对称环丙烷化等催化反应中的应用。     

The influence of a queen-produced substance, 9HDA,on swarm clustering behavior in the honeybeeApis mellifera L.

The effect of enantiomers of the queen-produced substance, 9-hydroxy-(E)-2-decenoic acid (9HDA) on swarm clustering behavior of the honeybeeApis mellifera was studied. Caged queens were removed from the swarms at the start of each test and were replaced with small Petri dishes containing one of the following treatments: 100 gS(+) enantiomer of 9HDA, 100 gR(-) enantiomer of 9HDA, 200 g racemic (R, S) 9HDA, and a vehicle-treated control. Each swarm was considered to have dispersed when it had lost 50% of its starting weight. All treatments with 9HDA resulted in significantly longer swarm aggregation when compared with the control. Enantiomers were not shown to have different effects at theP 0.05 level of significance. However, observations on swarm behavior indicated that theR(-) enantiomer was the most active in retarding swarm dispersal.     

最简单的手性分子—过氧化氢和过硫化氢

用范德华力和静电力分析了H_2O_2和H_2S_2的结构。它们都是手性分子,属于外消旋体。