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The addition of antimicrobial preservatives to pharmaceutical and cosmetic products is necessary to prevent microbial growth. However, the use of preservatives can also produce other undesirable effects. For several years, researchers have been investigating the use of alternative methods in safety assessment of cosmetic ingredients and formulations by means of variety methods. The aim of this study was to evaluate the erythrocyte toxicities of two commercial preservatives: imidazolidinyl urea and diazolidinyl urea. Relatively few studies about the cytotoxicity of these preservative are available. The determination of their cytotoxicity is an essential step to warrant their safe use. Erythrocyte toxicities were evaluated by assessment of the amount of hemoglobin released by red blood cells after their lysis. In this study, both imidazolidinyl urea and diazolidinyl urea showed cytotoxic activity against red blood cells. The imidazolidinyl urea induce a small release of hemoglobin after 120 min of incubation. But, the diazolidinyl urea induce a massive release of hemoglobin from the imidazolidinyl urea (a rate of 83% at concentrations of 6.25 mg/mL and 12.5 mg/mL). 相似文献
83.
基于人工神经网络的方法对主机安全性能进行量化评估。分析了BP人工神经网络模型的网络结构及学习算法,分析了影响目标主机安全性能的可能因素,并应用BP神经网络模型对目标主机的安全性能进行样本训练及实际测试。基于人工神经网络的主机安全量化评估为评价目标主机的安全性能提供了可行的方法。 相似文献
84.
The determinants of the premium value of patents for medical and cosmetic products are analyzed with respect to a complementary IP strategy such as trademarks. I discuss a novel method and database to gauge combinations of patent and trademark pairs regarding the same innovative project. The premium value is computed through a model of renewal decisions for the patent cohorts 1985–1990 that have been designated in the U.K. and Germany. After taking into the account several firm characteristics and patent indicators typically used in the literature, I find ample evidences that patent and trademark pairs are featured by higher valuations. 相似文献
85.
《日用化学工业》2024,54(5):605-613
多光子成像技术是一种观察人体皮肤组织结构的光学成像方法,其原理是利用不同波长的近红外激光使皮肤组织中特定的内源性或外源性荧光物质发出不同的荧光信号,从而观测、区分皮肤不同层的特定组织结构.近年来,该方法开始逐步应用于化妆品的评估中,如评估化妆品紧致抗皱、祛斑美白、透皮吸收的效果等.多光子成像技术能够通过监测皮肤形态或代谢的变化评估化妆品紧致抗皱的作用、定量黑色素分布和含量评估化妆品祛斑美白成分的功效性或判断特定皮肤的类型、可视化化妆品成分透皮吸收的过程评估其功效性或安全性.该方法获得的客观、可视化图像可以为化妆品评估提供定量的数据结果,在皮肤成像领域有着广阔的应用前景,本文综述了这种在体、无创、精准的三维成像方法在化妆品评估中的应用和进展. 相似文献
86.
Ang Xiao;Yuxin Yang;Xianglong Liu;Chong Shen;Qin Meng; 《Journal of surfactants and detergents》2024,27(3):355-365
Sulfate surfactants in cosmetic products raise concerns due to their skin irritating impact and sustainability. Rhamnolipid, a green and safe biosurfactant, was studied from the perspective of rheology to help develop a formulation with natural and effective ingredients for cosmetics. The viscosity of rhamnolipids was investigated by changing pH, concentration and adding additives like inorganic salts (NaCl, MgCl2) and polymers (Carbopol® Ultrez 20, Carbopol® Aqua SF-1, Carbopol® 940 and cationic guar gum), showing that the viscosity of rhamnolipid had a positive correlation with the increase of concentration, a negative correlation with the increase of pH, and that polymers instead of inorganic salts were suitable for thickening rhamnolipid. Further rheology tests indicated that Carbopol® Aqua SF-1 imparted gel properties of rhamnolipid while cationic guar gum determined the liquid properties. In addition, the rhamnolipid-containing moisturizing cream consisting of stearic acid/squalane ratios all showed shear-thinning and gel behavior the same as the commercial ones. Visual appearance and particle size analysis indicated that all formulations exhibited high storage stabilities. The knowledge gained from this study may be useful for designing “sulfonate-free” shampoo and cream with rheological properties that can be tailed for specific commercial cosmetic applications. 相似文献
87.
Pan Wang Yanting Hong Weixin Ke Xiaosong Hu Fang Chen 《Journal of the science of food and agriculture》2017,97(12):3967-3978
88.
C.F. Balthazar T.C. Pimentel L.L. Ferrão C.N. Almada A. Santillo M. Albenzio N. Mollakhalili A.M. Mortazavian J.S. Nascimento M.C. Silva M.Q. Freitas A.S. Sant’Ana D. Granato A.G. Cruz 《Comprehensive Reviews in Food Science and Food Safety》2017,16(2):247-262
Sheep milk has a high nutritional value and high concentrations of proteins, fats, minerals, and vitamins, as compared to the milks of other domestic species. The physicochemical and nutritional characteristics of sheep milk can be advantageous for the manufacture of products containing prebiotic ingredients and/or probiotic bacteria, which are major categories in the functional food market. Following this technological trend, this review will address the characteristics and advantages of sheep milk as a potentially functional food, as well as the development of sheep milk dairy products containing prebiotics and/or probiotics. 相似文献
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