电致孔经皮给药：表面活性剂对孔道存在时间和药物传输的影响

Electroporation creates aqueous pathways by short high-voltage pulses resulting in a transient perme- abilization of stratum corneum and an increase in the transdermal delivery rate.However the aqueous pathways will reseal after pulsing,which leads to the rapid drop of transdermal flux.In the present study,the surfactants were added to the donor solution to hinder the shrinkage and resealing of the electropore,and to prolong the lifetime of the aqueous pathways with the consideration that the surfactants could reduce the surface energy of the electropore. These effects of surfactants were demonstrated by the dynamic electrical resistance of the skin and the fluorescent imaging of the local transport regions.Piroxicam（PIX）was transported percutaneously in the presence of surfactants in vitro.Owing to the longer lifetime of aqueous pathways,together with the promotion of PIX availability at the barrier exterior and the improvement in the partition of PIX into the aqueous pathways,the presence of surfactants led to a remarkable increase in the transdermal delivery rate during electroporation and a significant growth of the accumulative transdermal amount of PIX.     

几种翅片管换热器的应用研究

介绍了翅片管换热器的特点、材料及型式，列出了3种翅片管换热器的应用示例，分析了在不同应用条件下翅片管的应用情况，并给出了应用结果，为翅片管换热器的应用方法提供了借鉴，最后分析了新型AIF翅片管换热器的研制及应用。     

我国化肥催化剂工业现状

全国48家化肥催化剂制造厂总能力为57Kt/a,产量近30kt/a,设备利用率不到50%。平均万吨氨耗催化剂10.36t,高于国外5.60t水平。现生产31个品种203个型号的催化剂中有103种经部级鉴定,但经常使用的约50种。目前化肥催化剂工业水平与国外相比还存在四方面差距。     

压力容器用封头制造质量控制和专业化生产发展方向

中国法规首次对压力容器等特种设备用封头实施制造资格许可和强制的监督检验制度。本文根据法规标准的规定,对压力容器封头制造质量控制和专业化生产发展方向的要求作一系统的综述,以提高压力容器产品的整体质量,确保特种设备安全万无一失。     

生物陶瓷人工骨制备的新方法

主要介绍了近年来发展起来的两种新技术 :快速原型制造技术和放电等离子烧结技术。概括了两种技术的原理、特点以及在人工骨制备中的应用 ,提出了用这两种技术制备人工骨的设想。     

采用加压-真空两段热缩聚法制备中间相沥青炭纤维的原料

以深度裂解石油渣油为原料，采用两段热缩聚法可制得软化点为268℃，可编性良好的中间相沥青。本文详细考察了温度，时间对中间相沥青软化点，可编性，中间相沥青形态及碳化收率的影响，并初步探讨了两段热缩聚反应的机理。研究结果表明反应温度，时间对中间相沥青的结构和性能影响较大，选择适宜石油渣油，采用加压－真空两段热缩聚法，调整反应条件，可制得可纺性良好的中间相沥青。     

Synthesis,degradation, and drug delivery of cycloaliphatic poly(ester anhydride)s

The high melting point of poly(1,4‐cyclohexanedicarboxylic anhydride) [poly(CHDA)] is a disadvantage, in that it is intractable in the melting process of a drug delivery system. This report relates to diols introduced into the polyanhydride main chain to decrease its melting point. Various poly(ester anhydride)s containing ethylene glycol, 1,3‐propanediol, 1,4‐butanediol, or 1,6‐hexandiol [poly(CHDA–XDO)] were synthesized by the esterification reaction and melt polycondensation. FTIR, DSC, WAXD, and intrinsic viscosity of polymers were recorded and hydrolytic degradation, as well as in vitro drug delivery, was conducted. The results show that the samples are stable in an anhydrous environment at room temperature and degrade in water following a surface erosion mechanism. The degradation period of poly(CHDA–XDO) ranged from 130 to 320 h as a result of the different diols and amounts of XDO introduced. The in vitro drug delivery gave 130–350 h of stable delivery along with the typical surface erosion mechanism. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2509–2514, 2002     

Release of salicylic acid through poly(vinyl alcohol)/poly(vinyl pyrrolidone) and poly(vinyl alcohol‐g‐N‐vinyl‐2‐pyrrolidone) membranes

A controlled release profile of salicylic acid (SA) for transdermal administration has been developed. Poly (vinyl alcohol) (PVA) and Poly(vinyl alcohol)/Poly(vinyl pyrrolidone) (PVP) blended preparations were used to prepare the membranes by solvent‐casting technique. The release of the drug from the membranes was evaluated at in vitro conditions. The effects of PVA/PVP (v/v) ratio, pH, SA concentration and temperature were investigated. 60/40 (v/v) PVA/PVP ratio was found to be the best ratio for the SA release. Increase in pH and temperature was observed to increase the transport of SA. Instead of blending PVA with PVP, N‐Vinyl‐2‐pyrrolidone (VP) was grafted onto the PVA and the delivery performance for SA was compared with that of the blended PVA/PVP membranes. Grafted membranes gave higher transport percentages than the blended membranes. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102:1244–1253, 2006     

多孔β-TCP陶瓷药物载体结构与性能的影响因素

本分析了影响多孔β-TCP陶瓷药物载体结构与性能的因素，确定了制备多孔β-TCP陶瓷药物载体的技术路线和工艺参数。