基于pH敏感型葡聚糖水凝胶微球的药物载体

以葡聚糖为原料,采用反相微乳液技术制备了一种含有席夫碱结构的葡聚糖基水凝胶纳米微球作为载体,通过交联剂聚乙烯亚胺(PEI)的静电吸附作用对药物模型8-羟基芘-1,3,6-三磺酸三钠盐(HPTS)进行了包埋,利用FTIR、SEM和DLS等对微球的结构和形貌进行了表征。结果表明,这种葡聚糖纳米水凝胶载药前后均具有良好的球形结构,平均粒径分别在459和648 nm左右。载药效果及药物释放行为研究发现,该葡聚糖纳米水凝胶可对HPTS进行有效负载,且其释放行为具有明显的酸性环境敏感性,酸性越强,释放越快。含有席夫碱结构的葡聚糖纳米凝胶微球可作为pH敏感型载体应用于药物递送领域。     

高矣物的特性对双水相相图和头孢氨苄及7-ADCA分配行为的影响

A series of ethylene oxide(EO)-propylene oxide (PO) random co-polymers (EOPO) were used to form aqueous two-phase systems (ATPS) with ammonium sulfate.Effects of EOPO′s properties on the phase separation behaviors and on the partition of cephalexin and 7-aminodesacetoxicephalosporanic acid(7-ADCA) in ATPS were investigated.Both the molar mass and molar ratio of EO to PO of EOPO could greatly influence partition behaviors of cephalexin and 7-ADCA as well as the binodal curve of ATPS. With the increase of molar mass of co-polymer or the decrease of molar ratio of EO to PO,the critical point of ATPS decreased,the binodal curve became more asymmetry,and both cephalexin and 7-ADCA followed the same tendency to partition into the polymer-poor bottom phase.The experimental results shows that it is feasible to partition cephalexin and 7-ADCA in either the polymer-rich top phase or the polymer-poor bottom phase by choosing a specific phase-forming EOPO.     

Preparation of porous poly(lactic acid)/Sio2 hybrid microspheres

With 3‐aminopropyltriethoxysilane (APTES) as coupling agent, poly(lactic acid) (PLA)/SiO₂ hybrid material was prepared to produce poly(lactic acid)/SiO₂ hybrid microspheres (PLAHs) with porous structure bythe oil‐in‐water, single‐emulsion solvent evaporation method. Field scanning electron microscopy results show that the PLAHs were porous microspheres about 20 μm in diameter. The holes in the PLAHs opened outside and were not complicated. A nitrogen adsorption–desorption experiment showed that the nitrogen adsorbed in the holes was easily desorbed, and the specific surface area of the PLAHs was calculated to be 6.87 m²/g according to the Brunauer–Emmett–Teller equation. Fourier transform infrared spectroscopy results show that PLA was amidated with APTES successfully and formed a kind of organic–inorganic hybrid material by hydrolysis and con‐condensation with tetraethoxysilane. Moreover, the molecular structure of the hybrid material was confirmed by X‐ray photoelectron spectroscopy. Differential scanning calorimetry results show that the melting point ofthe PLAHs was higher than that of PLA by about 11.2°C. These PLAHs may be used in the controlled release of drugs by the embedding of the drugs in the holes of the PLAHs, and the drug loading amount can be controlled by the size and number of holes in the PLAHs. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 679–683, 2006     

基于多目标优化的多源组播网络编码的构造

在基于单目标优化构造网络编码的基础上,提出了基于多目标优化的网络编码的构造方法。把多源组播网络划分成多个单源组播网络,各单源组播网络的组播容量互相制约,为了使各单源组播网络的组播容量达到最大,采用粒子群优化算法进行子图划分,动态求解包含各子图组播容量的Pareto解集。用户可以优先考虑某个子图的组播容量,选择相应的解向量进行线性网络编码构造。仿真测试结果表明,本方法是可行的。     

一种基于改进FCM划分算法的T—S模型辨识

鉴于以往T—S模型建模过程中,在模糊划分上存在主观性的差异,提出了一种基于改进模糊C-均值算法的模糊划分方法,使划分结果尽可能地依赖于原始数据的分布情况,进而将该模糊划分算法用于多输入单输出非线性系统的基于T—S模型模糊辨识。在用该方法对多参量水质评价系统进行基于T—S模型模糊辨识建模时,取得了较好的验证效果。该研究结果表明,基于改进模糊C-均值划分算法的T—S模型辨识能在模糊综合评价与决策等应用领域中取得较好的应用效果。     

Snort体系结构的优化

针对入侵检测系统Snort在网络流量较大时不能处理数据而产生丢包的问题,可在该系统原有的基础上采用分流技术,即在数据包检测模块前添加协议分流模块和负载分流模块。实验表明,所设计的体系结构分流后,系统能够有效检测出包含在网络数据包中的入侵行为,避免丢包漏报现象,从而提高系统对网络流量检测的可靠性。     

基于径向基函数的曲面重建算法

针对基于传统径向基函数的数据插值方法在重建大量数据点云曲面时的困难,提出将数据点先分割再分别重建的方法.将点云的包围盒沿坐标轴分割,两两合并相邻的方块,使得方块相互重叠且覆盖整个包围盒.对每个包围盒内的点用径向基函数方法插值,利用窗口函数将每个函数限制在各小方盒内求和得到最终的整体插值曲面.借助MC（marching cubes）方法得到三角网格曲面.每个方块内点云的重建过程可以并行实现,因此该方法非常适用于对重建效率要求较高的场合.     

改进Delaunay三角剖分算法

针对传统Delaunay算法对非凸三维曲面剖分结果不理想,提出了基于凸划分的改进Delaunay三角剖分算法．研究了复杂曲面剖分的特性,定义了非凸集合凸划分定理,对任意曲面相对投影平面进行划分．利用一组正交平面对任意复杂曲面的划分,通过变换域对曲面进行了Delaunay三角剖分．实验结果表明,改进算法能够在正交平面对头面数据集合进行正确凸划分,在投影平面改进Delaunay三角剖分结果正确,鲁棒性明显增强,并与理论分析一致,验证了改进算法的正确性和有效性．     

Study on volume ratio and plasticizer screening of free coating membranes composed of ethyl cellulose and chitosan

The aim of this study was to optimize the formula of free blended coating membrane of ethyl cellulose (EC) and chitosan (CS), including their suitable ratio range and the best plasticizer used. The dry films were produced by a casting/solvent evaporation method, with different volume ratio of EC and CS solution plasticized by various plasticizers, respectively. The wet films were prepared by immersing dry films in pH 6.8 phosphate buffer saline (PBS) for 24 h. The promising ratio range of EC/CS was below 20/5 or 20/6 with various plasticizer, which was determined by comparing the viscosity of the blended solutions and the morphology of the blended films. The efficiency of plasticization was evaluated by measuring glass transition temperature (T_g). All the testing plasticizers have good compatibility with EC or CS and dibutyl phthalate (DBP) have the strongest efficiency inducing the lowest T_g (39.9°C) of the film. Mechanical properties were evaluated by the ratio of tensile strength (T) to elastic modulus (E). In the wet state, the films with DBP had the highest T/E value (1.2). The results of leaching of plasticizers also verified that DBP was the most stable plasticizer in the films. The release rates of tetramethylpyrazine phosphate (TMPP) through the pellets coated with the blended films of EC/CS (20 : 6 v/v) plasticized by various plasticizers showed that the more water‐soluble the plasticizer was, the more quickly TMPP dissolved from the coated pellets, which further indicated that the water‐insoluble plasticizers (such as DBP) could be more applicable to keep the sustained or controlled release property of the blended films in wet state. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 1932–1939, 2006     

Cephazoline sodium release from poly(N‐isopropyl acrylamide‐co‐N,N‐dimethylacrylamide) hydrogels

Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water, preserving their shape. The dynamic swelling behavior of poly(N‐isopropylacrylamide‐co‐N,N‐dimethylacrylamide) [poly(NIPA‐co‐DMA)] copolymers at 37°C was investigated. It was observed that the swelling degree in the copolymers decreases with the N‐isopropylacrylamide content. In addition, the liberation mechanism was found to be Fickian. Diffusion coefficients according to Fick′s law as a function of the N‐isopropylacrylamide concentration and results of the release process are reported. The kinetics of cephazoline sodium release from poly(NIPA‐co‐DMA) hydrogels with different compositions was studied. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 91: 3433–3437, 2004