Experimental Study on Energy Consumption of Combined Conventional and Dehumidification Drying

Conventional drying, dehumidification drying, and combined conventional-dehumidification drying of wood were experimentally studied in this article. The results showed that the energy consumption in the dehumidification drying is the least but its drying time is the longest. The energy consumption in the combined drying is more than that in the dehumidification drying but less than that in the conventional drying, and the drying time is half of that in the dehumidification drying. The advantages of the combined conventional and dehumidification drying are discussed from the experiments results.     

间苯二酚－甲醛有机气凝胶的结构控制研究

以间苯二酚（Ｒｅｓｏｒｃｉｎｏｌ）－甲醛（Ｆｏｒｍａｌｄｅｈｙｄｅ）为原料，用溶胶－凝胶法和超临界干燥工艺制备了纳米多孔ＲＦ有机气凝胶。系统研究了原料配比、催化剂的使用、反应温度及溶剂用量等因素对ＲＦ气凝胶凝结时间和结构的影响，可以实现对该材料的结构进行纳米尺寸上的控制，从而为该材料的应用开发奠定了基础。     

石膏制品防水防潮剂的研制与开发

本文提出采用高分子有机材料配合，生产石膏制品防水防潮剂的生产方法和工艺。该剂还可以应用到氧化镁系列板材，同时提出开发珠光或彩色防水防潮剂，能达到满足的装饰效果，值提开发推广。     

Whey Drying on Porous Carriers

Whey is an undurable product. treated very often as a waste which pollutes the natural environment. Whey which is a valuable source of protein, lactose, vitamins and mineral salts should be utilized completely. The present paper is a proposal of whey drying on porous carriers. It is proved experimentally that the proposed drying method guarantees good product quality.     

Air entrainment in fresh concrete with PFA

The results of a study into the influence of PFA on air entrainment in fresh concrete are discussed It is shown that the required dosage of AEA to produce an air content of 5.5 ± 0.5% in a PFA modified concrete mix is two-six times that required in the corresponding neat OPC concrete mix. The dosage of a vinsol based air entraining agent (AEA) required appears to be directly related to the PFA content of the mix. Similar direct relationships were obtained with a range of different PFAs. The dosage of an AEA based on the salt of a fatty acid appears to be sensitive to both PFA and OPC contents. For the type of PFA used, the variability of measured air content or the amount of air retained after continued agitation both indicated that vinsol based AEAs show the highest variability whilst fatty acid based AEAs show low variability. The between batch variability of air content was significantly improved by the addition of PFA regardless of the AEA used.     

AI paradigms

The aim of this paper is comparative analysis of most important AI paradigms. An AI paradigm is defined as the pair composed by a concept of intelligence and a methodology in which intelligent computer systems are developed and operated. Three paradigms, the behaviourist paradigm, the agent paradigm, and the artificial life paradigm are discussed.     

ANALYSIS OF OPEN SUN DRYING EXPERIMENTS

Open sun drying has lost its previous importance due to the fact that different factors affect its reliability and the quality of the products obtained.

One of the set-backs for the analysis of solar drying exoeriments is their deoendence on a non-controlled source of energy, i.e. solar radiation depends on climatic conditions and experiments are difficult to compare. It is thus necessary to investigate the advantages of a particular set up as well as the climatic influences. Open sun drying could constitute the natural reference, allowing the comparison of different drying strategies.

A new way of standardizing drying times, based on solar radiation inout, is proposed, to allow better evaluation of the experiments. An equivalent time is defined, allowing comparison of experiments carried out under different circumstances. Carrots and potatoes were used in these experiments.

The use of the average daily solar radiation 15.28 MJ m^-2.d^-1 in Palma de Mallorca (39.33°N, 2.37°E), is proposed for comparison purposes. An improvement of more than 12 % in the explained variance was observed, the unexplained variance being lower than 1 %.     

无线网络的分布式入侵检测模型研究

对无线网络安全方面的问题和无线网络的特点进行了概述,分析了无线网络的入侵检测模型进行了分析,提出了一个分分布式的无线网络入侵检测系统模型,并给出了具体的拓扑结构设计,通过实验,证明这个入侵检测系统的设计和实现具有很好的安全性,其安全保障具有一定的实用性,值得推广。     

Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PL^pro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide ( 2 b ), which is known to bind into the S3 and S4 pockets of the SARS-CoV PL^pro. Moreover, we report the discovery of isoindolines as a new class of potent PL^pro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL^pro are valuable starting points for the development of new pan-coronaviral inhibitors.     

Mutual Prodrugs of 5-Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs

The development of potent antitumor agents with a low toxicological profile against healthy cells is still one of the greatest challenges facing medicinal chemistry. In this context, the “mutual prodrug” approach has emerged as a potential tool to overcome undesirable physicochemical features and mitigate the side effects of approved drugs. Among broad-spectrum chemotherapeutics available for clinical use today, 5-fluorouracil (5-FU) is one of the most representative, also included in the World Health Organization model list of essential medicines. Unfortunately, severe side effects and drug resistance phenomena are still the primary limits and drawbacks in its clinical use. This review describes the progress made over the last ten years in developing 5-FU-based mutual prodrugs to improve the therapeutic profile and achieve targeted delivery to cancer tissues.