采用脲类快速固化环氧粉末涂料

有机脲类化合物可以单独作为一种优良的快速固化剂,不但固化速度快,并且有优良的附着性能。ND快速潜伏性环氧树脂固化剂是一种有机脲类化合物,环氧粉末涂料中加入4％,固化温度为180℃时,粉料1min可以完全固化。     

药物中间体(R)-苄基缩水甘油醚的生物法制备研究

为获得手性苄基缩水甘油醚,以苄基缩水甘油醚为唯一碳源,从土壤中筛选到一株能对映选择性水解拆分苄基缩水甘油醚,获得相应(R)-对映体的菌株,经鉴定为白曲霉,命名为Aspergillus candidus ZJUTZQ041。并利用其冻干细胞,对苄基缩水甘油醚的生物催化拆分进行了研究,最终确定在30℃,磷酸钾缓冲液pH7.6,细胞与底物比为9∶1,助溶剂为二甲基亚砜条件下转化12 h,剩余R型底物的e.e.s值能从62.7%提高到94.7%。     

利用置换化学镀制备微米尺度覆银铜粉

目的 开发新型的置换化学镀方法,制备微米尺寸的覆银铜粉,进一步开展覆银铜粉在导电胶中的应用研究.方法 通过改变置换反应的时间,分别得到10～60℃内银的覆载量的变化曲线,通过拟合表面反应动力学方程,得到该反应在不同温度下的速率常数.对所获得的材料开展XRD、SEM等的表征,并利用该材料开展了导电胶的应用研究.结果 通过...     

多相氧化组合反应器与耦合分离新技术的研究构想与前景展望

目前大量化学品经过氧化反应制造,如重要的有机化工原料环氧丙烷(PO)、环氧氯丙烷(ECH)和盐酸羟胺等,现有工艺存在严重的“三高”问题,环保、经济和安全性方面需全面提升。国内自主创新的H₂O₂氧化工艺是以H₂O₂为氧化剂、在钛硅分子筛催化下的氧化反应,具有原子经济、环境友好等优点。但该过程是强放热的多相快反应,反应器设计与工程放大亟需解决高效混合、快速换热和安全性等问题,而氧化副产物的高效分离则是另一共性问题。基于以上问题,本项目进行了从基础研究到工业应用的全链条设计和一体化实施,重点解决H₂O₂氧化体系的分子混合与界面传递机理、跨尺度传递与反应耦合机制和反应器放大规律及过程强化新途径三个共性科学问题。项目完成后将形成多个自主产业化成套技术,建成两个H₂O₂绿色氧化体系工业示范装置(环氧丙烷工业示范装置、盐酸羟胺工业示范装置)以及环氧氯丙烷成套新技术工艺包,同时打破国外技术的封锁与垄断,颠覆和淘汰污染环境严重的现有工艺,实现节能环保绿色清洁生产。     

Effect of water concentration on photopolymerized acrylate/epoxide hybrid polymer coatings as demonstrated by Raman spectroscopy

Photopolymerization systems based on hybrid monomer 3,4-epoxy-cyclohexylmethyl methacrylate (METHB) were studied to investigate water effects on conversion and polymer coating properties. METHB contains epoxide and methacrylate moieties, which undergo cationic and free-radical photopolymerization, respectively. The conversion of both groups was obtained by Raman spectroscopy in real time and depth. Water concentration and initiator system compositions were varied and shown to affect reaction kinetics and depth profile. With increasing water concentration, the epoxide induction period increased when only cationic initiator was present; however, the induction period disappeared when using the dual-initiator system. In addition, epoxide groups continued reacting after light was shuttered and reached a higher and more homogeneous conversion. Hybrid systems were shown to be less sensitive to water at low or intermediate concentrations. With high water concentrations, hybrid monomer systems manifested increased ring opening during illumination due to chain transfer and decreased physical properties due to loss of cross-linking.     

金属卟啉络合体系引发的环状化合物开环聚合

按照阴离子配位机理卟啉络合体系在引发环状化合物的开环聚合,形成窄分布,可控分子量聚合物方面具有显著优越必训在分析该引发体系结构特点的基础上,综述了金属卟啉络合体 催化机理,开环聚合方式以及与该体系有在的新催化合成方法。     

Proteasome Inhibitors and Their Pharmacokinetics,Pharmacodynamics, and Metabolism

The proteasome is responsible for mediating intracellular protein degradation and regulating cellular function with impact on tumor and immune effector cell biology. The proteasome is found predominantly in two forms, the constitutive proteasome and the immunoproteasome. It has been validated as a therapeutic drug target through regulatory approval with 2 distinct chemical classes of small molecular inhibitors (boronic acid derivatives and peptide epoxyketones), including 3 compounds, bortezomib (VELCADE), carfilzomib (KYPROLIS), and ixazomib (NINLARO), for use in the treatment of the plasma cell neoplasm, multiple myeloma. Additionally, a selective inhibitor of immunoproteasome (KZR-616) is being developed for the treatment of autoimmune diseases. Here, we compare and contrast the pharmacokinetics (PK), pharmacodynamics (PD), and metabolism of these 2 classes of compounds in preclinical models and clinical studies. The distinct metabolism of peptide epoxyketones, which is primarily mediated by microsomal epoxide hydrolase, is highlighted and postulated as a favorable property for the development of this class of compound in chronic conditions.     

双金属催化环氧化物聚合诱导期的研究

用观察反应体系压力变化的方法测定了不同条件下双金属氰化络合催化剂催化环氧丙烷(PO)聚合的诱导期。发现诱导期与催化剂的结构组成、反应温度、体系中水分含量、分子量调节剂和溶剂的种类及用量等因素有关。适当地提高聚合温度,严格控制体系中水分含量,并选择合适的分子量调节剂和加料工艺均能够有效地缩短诱导期。     

钢纤维增强煤矸石树脂混凝土建筑应用试验研究

在对阜新煤矸石、粉煤灰进行基本性质检测的基础上,将煤矸石破碎人工级配作集料、粉煤灰作填料.采用均匀试验设计安排试验方案,利用SPSS技术处理试验数据并建立强度回归方程,用MATLAB技术得到树脂混凝土的配合比优化范围,并阐述了钢纤维的增强机理.     

液体聚异戊二烯对天然橡胶/环氧化天然橡胶共混物结构与性能的影响

研究了液体聚异戊二烯(LIR)对天然橡胶(NR)/环氧化天然橡胶(ENR)共混体系的加工性能、硫化特性、物理力学性能、耐热氧硫化性能、动态力学性能及微观结构的影响。结果表明,加入LIR提高了体系的加工性能,硫化性能和物理力学性能基本不变,体系的耐热氧老化性能提高。少量的LIR的加入可提高体系的抗湿滑性,同时滚动阻力略有下降。LIR还可有效提高炭黑在NR/ENR体系中的分散。