Behavioral Phenotype of the Reeler Mutant Mouse: Effects of Reln Gene Dosage and Social Isolation.

Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

非线性设备与编辑录像机遥控部分的接口技术

从RS—232C，RS—422接口标准及RS—232C与RS—422的电平转换等方面详细地介绍非线性设备与编辑录像机遥控部分的硬件接口技术，给出了相关的电路原理图，指出了使用时的一些注意事项。     

Yeast mutants with increased bacterial transposon Tn5 excision

Five complementing recessive mutations that exhibit increased bacterial transposon Tn5 precise excision in yeast Saccharomyces cerevisiae were obtained by ethylmethanesulfonate treatment. One of these mutations (tex1) was submitted to extensive genetic analysis. tex1 is a recessive temperature-sensitive mutation resulting in a 20-100-fold increase in Tn5 excision. It also has increased frequencies of ochre mutation reversion, of forward mutation to canavanine resistance, and loss of chromosome III or its right arm. The possible mechanism of tex1 effects is discussed.     

筛查基因突变的新技术——循环双脱氧指纹图谱法及其应用

建立了适用于大批量标本基因突变筛查的双脱氧指纹图谱法即ｄｄＦ。该技术民测定ＤＮＡ序列的双脱氧末端终止法及ＳＳＣＰ二者长处于一身，即只作一个双脱氧末端终止反应，然后将反应产物在与ＳＳＣＰ相同的电泳条件下进行聚丙烯酰胺凝胶电泳，这样有突变的样品不会漏检，阳性检出率高达１００％。     

期刊稿件网络采编系统的建立

《中国冶金》杂志社全面启用的科技期刊稿件采编系统是以Internet为载体，具有作者在线投稿、在线查询、上传校样、专家在线审理稿件、提交审稿意见、上传审改稿、编辑在线加工处理稿件等作用，完全实现了稿件从收稿到发稿的全程数字化管理，同时建立了数据齐全、操作简便的作者、审稿专家和稿件的数据库，改进了传统的操作方法和管理模式，提高了工作效率。杂志社采用该系统还可以进行网刊发布、管理以及期刊征订和发行处理。     

基于基因表达式的克隆选择算法求解JSP问题

针对作业车间调度问题的特征,提出一种基于基因表达式的克隆选择算法。在这个方法中,采用基因表达式编程算法中的编码方式来表示调度方案,同时为了提出的方法具有更强的全局搜索能力,运用克隆选择算法作为搜索引擎。最后,验证提出的方法的有效性,对7组Benchmark实例进行测试。实验结果表明,基于基因表达式的克隆选择算法在求解作业车间调度问题中是非常有效的。     

机器人足球比赛系统中的机器人任务分配方法

针对基于遗传算法的多机器人任务分配方法中,由于初始种群是随机产生不能很好地表征整个解空间,而容易陷入局部最优解的问题,提出一种新的多机器人任务分配方法。该方法根据机器人效用函数值来确定个体基因,从而产生初始种群,并引进分层遗传算法来实现具有不同最优基因的群体分开演化。仿真实验表明,该方法比传统的遗传算法有更高的寻优效率和更快的收敛速度。     

Unseen users, unknown systems: Computer design for a scholar's dictionary

The Dictionary of Old English computing systems have provided access since the 1970s to a database of approximately three million running words. These systems, designed for a variety of machines and written in a variety of languages, have until recently been planned with computing center billing algorithms in mind. With personal workstations emphasis has shifted to building more elegant user interfaces and to providing the entire DOE database to editors around the world. While the shift from sequential files to random access files and the provision of extensive development tools have changed some of the design process, error checking and protection of the database against accidental intrusion have remained as central issues.Richard L. Venezky is Unidel Professor of Educational Studies and professor of Computer and Information Sciences at the University of Delaware. He was formerly professor and chair of Computer Sciences at the University of Wisconsin. His research interests include writing systems, literacy, knowledge representation, and computer-assisted instruction. Among his recent publications are The Subtle Danger: Reflections on the Literacy Abilities of America's Young Adults (Princeton, NJ: ETS, 1987), and Steps Towards a Modern History of American Reading Instruction (Review of Research in Education, 1986, vol. 13, 129–70).