Critical State of Granular Materials Based on the Sliding-Rolling Theory

By representing the assembly by a simplified column model, a constitutive theory was recently developed for a two-dimensional assembly of rods. This theory, referred to as the sliding-rolling theory, is extended in this paper to represent the triaxial stress-strain behavior of granular materials. The sliding-rolling theory provides a dilatancy rule and an expression for the slope of the line of zero dilatancy in the stress space. These rules are then combined with triaxial observations to provide a microstructural interpretation of the critical state of granular materials. According to the theory, the slope of the critical state line in the stress space depends on the interparticle friction angle and the degree of contact normal anisotropy. To verify the basic ideas of the sliding-rolling theory, numerical experiments are conducted using the discrete-element method on three-dimensional assemblies of spheres.     

基于三点工况下的无源滤波器组优化设计

无源滤波器组的参数设计通常均针对系统单一工况(通常为最大工况)进行。当系统运行在其他工况时,有可能无论退出哪一组滤波器的运行均无法同时满足系统的无功补偿和谐波治理要求。为此基于系统的3种典型工况(最大、平均和最小工况)对无源滤波器组进行优化设计,确定合理参数,以在最小的投资费用下达到谐波治理与无功补偿的最优匹配。算例结果验证了该方法的可行性。     

Review of Evolution, culture and the human mind.

Reviews the book, Evolution, culture and the human mind edited by M. Schaller, et al. (see record 2009-20004-000). This current volume, Evolution, culture and the human mind, follows the lead of Wundt where an attempt is made to provide a synthesis of theory and data across psychological subfields into a holistic framework. Norenzayan, Schaller, and Heine begin the volume with an overview of the scope and themes that arose from their 2004 conference at the University of British Columbia on “Mind, Culture and Evolution.” Explicit throughout this volume is an effort to bridge the “yawning chasm” between perspectives of evolutionary determinism and cultural constructionism. In doing so, there is interest in providing a rigorous multidisciplinary scientific effort to solve this foundational problem for psychology. As such this volume provides an interesting and insightful examination of the evolution of consciousness, cognition, decision-making, actions, and cultural norms in terms of collective consequences and genetic mechanisms. The volume is divided into three sections where several dialectical themes (theory/data, top-down/bottom-up, ecological/social, diversification/integration) are woven throughout. Overall the volume offers nice flow from one collection of essays to the next as themes are picked up and let go, only to return later on. This volume shows a dominance of natural science (cross-cultural) inclinations where some readers may call for more voice given to phenomenological and hermeneutical (cultural) human science contributions. Other critics may challenge the reliance upon correlational, comparative, and post hoc data to bolster claims of causality in support of various theoretical suppositions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

基于GA的2DPCA在人脸识别中的应用

采用基于遗传算法(GA)的二维主成分分析法(2DPCA)进行人脸识别.2DPCA直接以二维图像矩阵为研究对象,以其协方差矩阵的特征向量为投影轴进行特征提取.为了达到识别时的信息最优,将遗传算法融入2DPCA,对协方差矩阵的特征向量进行优化选择得到最优投影轴,并在此基础上提取特征.最后在MIT人脸数据库上进行实验,表明识别率和速度均高于单纯使用2DPCA的方法.     

遗传算法在隧洞开挖爆破参数优化中的应用

介绍了利用遗传算法优化隧洞开挖爆破参数的理论和方法。以及该算法在阿荣旗-深圳高速公路隧洞爆破开挖工程中的应用。实例表明,利用遗传算法来调整爆破参数和支护参数,可以有效地降低隧道爆破成本。     

TAS2R38 Bitter Taste Receptor Expression in Chronic Rhinosinusitis with Nasal Polyps: New Data on Polypoid Tissue

Studies have shown differences in TAS2R38 receptor expression in patients with chronic rhinosinusitis (CRS) compared to healthy controls. Known agonists of TAS2R38 stimulate epithelial cells, leading to robust intracellular nitric oxide (NO) production, which damages bacterial membranes, enzymes, and DNA, but also increases ciliary beat frequency. In this study we examined, using qRT-PCR, the expression of TAS2R38 receptor in nasal polyps (NP) of patients with CRS (N = 107) and in inferior turbinate mucosa (ITM) of patients with CRS and controls (N = 39), and confronted it with clinical features and the severity of the disease. The expression was shown in 43 (50.00%) samples of ITM in the study group (N = 107), in 28 (71.79%) in the control group (N = 39) (p = 0.037), and in 43 (46.24%) of NP. There were no differences in levels of the expression in all analyzed tissues. Patients who rated their symptoms at 0–3 showed higher TAS2R38 expression in ITM in comparison to the patients with 8–10 points on the VAS scale (p = 0.020). A noticeable, however not significant, correlation between the TAS2R38 expression in ITM and the Lund–Mackay CT score was shown (p = 0.068; R = −0.28). Patients with coexisting asthma had significantly higher receptor expression in the NP (p = 0.012). Our study is the first to confirm the presence of the TAS2R38 receptor in NP. Expression of the TAS2R38 receptor is reduced in the sinonasal mucosa in patients with more advanced CRS with NP.     

Gene Variants Related to Cardiovascular and Pulmonary Diseases May Correlate with Severe Outcome of COVID-19

Background: Severe outcomes of COVID-19 account for up to 15% of all cases. The study aims to check if any gene variants related to cardiovascular (CVD) and pulmonary diseases (PD) are correlated with a severe outcome of COVID-19 in a Polish cohort of COVID-19 patients. Methods: In this study, a subset of 747 samples from unrelated individuals collected across Poland in 2020 and 2021 was used and whole-genome sequencing was performed. Results: The GWAS analysis of SNPs and short indels located in genes related to CVD identified one variant significant in COVID-19 severe outcome in the HADHA gene, while for the PD gene panel, we found two significant variants in the DRC1 gene. In this study, both potentially protective and risk variants were identified, of which variants in the HADHA gene deserve the most attention. Conclusions: This is the first study reporting the association between the HADHA and DRC1 genetic variants and COVID-19 severe outcome based on the cohort WGS analysis. Although all the identified variants are localised in introns, they may be correlated and therefore inherited along with other risk variants, potentially causative to severe outcome of COVID-19 but not discovered yet.     

Heterologous Expression of Xylanase xAor from Aspergillus oryzae in Komagataella phaffii T07

Xylanases (EC 3.2.1.8) hydrolyze the hemicellulose of plant cell walls. Xylanases are used in the food and paper industries and for bioconversion of lignocellulose to biofuel. In this work, the producer-strain with four copies of the xAor xylanase gene was organized in two tandem copies for optimal expression in Komagataella phaffii T07 yeast. The secreted 35 kDa xylanase was purified from culture medium by gel filtration on Sephadex G-25 and anion exchange chromatography on DEAE-Sepharose 6HF. Tryptic peptides of the recombinant enzyme were analyzed by liquid chromatography-tandem mass spectrometry where the amino acid sequence corresponded to Protein Accession # {"type":"entrez-protein","attrs":{"text":"O94163","term_id":"74582795","term_text":"O94163"}}O94163 for Endo-1,4-beta-xylanase from Aspergillus oryzae RIB40. The recombinant xylanase was produced in a bioreactor where the secreted enzyme hydrolyzed oat xylane with an activity of 258240 IU/mL. High activity in the culture medium suggested xylanase could be used for industrial applications without being purified or concentrated. The pH optimum for xylanase xAor was 7.5, though the enzyme was active from pH 2.5 to pH 10. Xylanase was active at temperatures from 35 °C to 85 °C with a maximum at 60 °C. In conclusion, this protocol yields soluble, secreted xylanase suitable for industrial scale production.     

FNN与混合遗传算法在智能优化的策略比较

FNN是一种重要的神经网络结构,混合遗传算法是一种正在兴起的启发式随机搜索技术,两者在智能优化中得到了广泛的应用。两者的优化机理不同,方法不同,各有千秋。论文从提高两者的优化性能出发,研究其智能优化的实现策略,并对两者进行了比较,得出了有意义的结论。     

基于软计算思想解决含干扰输入多值异或问题的研究

介绍一种解决含干扰输入多值异或问题的方法。该方法利用遗传算法寻找神经网络结构,使用模糊逻辑控制神经网络的学习率和冲量,并用传播算法训练得到神经网络。结果显示,这种方法能针对问题得到泛化性能、时间复杂度上表现都较为优秀的网络。