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Mariantonia Logozzi Rossella Di Raimo Davide Mizzoni Stefano Fais 《International journal of molecular sciences》2022,23(9)
Research in science and medicine is witnessing a massive increases in literature concerning extracellular vesicles (EVs). From a morphological point of view, EVs include extracellular vesicles of a micro and nano sizes. However, this simplistic classification does not consider both the source of EVs, including the cells and the species from which Evs are obtained, and the microenvironmental condition during EV production. These two factors are of crucial importance for the potential use of Evs as therapeutic agents. In fact, the choice of the most suitable Evs for drug delivery remains an open debate, inasmuch as the use of Evs of human origin may have at least two major problems: (i) autologous Evs from a patient may deliver dangerous molecules; and (ii) the production of EVs is also limited to cell factory conditions for large-scale industrial use. Recent literature, while limited to only a few papers, when compared to the papers on the use of human EVs, suggests that plant-derived nanovesicles (PDNV) may represent a valuable tool for extensive use in health care. 相似文献
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Fei Wei Pengyun Chen Hongliang Jian Lu Sun Xiaoyan Lv Hengling Wei Hantao Wang Tingli Hu Liang Ma Xiaokang Fu Jianhua Lu Shiyun Li Shuxun Yu 《International journal of molecular sciences》2022,23(9)
As one of the most important factors in alternative splicing (AS) events, serine/arginine-rich (SR) proteins not only participate in the growth and development of plants but also play pivotal roles in abiotic stresses. However, the research about SR proteins in cotton is still lacking. In this study, we performed an extensive comparative analysis of SR proteins and determined their phylogeny in the plant lineage. A total of 169 SR family members were identified from four Gossypium species, and these genes could be divided into eight distinct subfamilies. The domain, motif distribution and gene structure of cotton SR proteins are conserved within each subfamily. The expansion of SR genes is mainly contributed by WGD and allopolyploidization events in cotton. The selection pressure analysis showed that all the paralogous gene pairs were under purifying selection pressure. Many cis-elements responding to abiotic stress and phytohormones were identified in the upstream sequences of the GhSR genes. Expression profiling suggested that some GhSR genes may involve in the pathways of plant resistance to abiotic stresses. The WGCNA analysis showed that GhSCL-8 co-expressed with many abiotic responding related genes in a salt-responding network. The Y2H assays showed that GhSCL-8 could interact with GhSRs in other subfamilies. The subcellular location analysis showed that GhSCL-8 is expressed in the nucleus. The further VIGS assays showed that the silencing of GhSCL-8 could decrease salt tolerance in cotton. These results expand our knowledge of the evolution of the SR gene family in plants, and they will also contribute to the elucidation of the biological functions of SR genes in the future. 相似文献
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Coelho Jennifer; Roefs Anne; Havermans Remco; Salvy Sarah-Jeanne; Jansen Anita 《Canadian Metallurgical Quarterly》2011,43(1):63
Psychological processes may play a role in the evaluation of the effectiveness of exercise and subsequent food intake. In order to further investigate this phenomenon, the effects of the timing of exercise relative to an eating opportunity were evaluated. Female undergraduate participants who were of average weight and did not exercise regularly were randomly assigned to one of three conditions (exercise before eating [n = 10], exercise after eating [n = 11], or no exercise [n = 12]). Expectations of the effectiveness of the exercise, value of dieting, and intake were assessed. Participants who exercised after eating had higher expectations of the effectiveness of the exercise than those who exercised before eating, while those who exercised before eating reported valuing dieting more than controls. No effects on intake emerged; therefore, there appears to be a disconnect between dieting appraisals and actual eating behaviour. The results are discussed in relation to theories on conflicting goals. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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随着知识经济的到来,职工培训在组织发展中扮演着越来越重要的角色。本文针对盐业钻井大队职工培训的现状,进行了问题分析,提出了建立学习型组织、完善的培训体系和畅通的运行机制的建议,最后强调了制定培训计划应从加强培训需求性的调查研究、加强组织培训的协调性等五个方面把握。 相似文献
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研究了10%的单氟磷酸钠溶液作为表面处理剂对碳化高炉矿渣水泥砂浆耐久性的影响。砂浆养护10d后或暴露在自然环境中1a后,进行表面处理,这2种处理方式分别称为前处理与后处理。通常情况下,砂浆在碳化侵蚀后其微观结构被严重破坏。处理后的砂浆经碳化后的微观结构大为改观。试验结果表明:处理后的碳化高炉矿渣水泥砂浆的抗冻融循环能力得到了很大提高。 相似文献
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The human body responds psychologically and physiologically to the thermal environment to which it is exposed. Fanger's PMV model has been adopted for the design of built environments and building maintenance from the end of the 1960s. The sperm quality of humans has been decreasing since the 1970s. The thermal environment is one of the most important factors of the Sick Building Syndrome (SBS). It is well known that spermatogenesis is very sensitive to heat exposure. Mild thermal exposure increases tissue microcirculation and consequently produces an appropriate supply of nutrients and oxygen to tissue cells; thus, it can modulate the proliferation of Sertoli cells in which the spermatogonia stem cells develop into adult spermatozoa. Excessive exposure to heat is harmful to spermatogenesis, and excessive testicular cooling can cause the cessation of spermatogenesis. 相似文献
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用熔盐法制备了锶铁氧体(SrM)磁粉,改变盐的种类及组成、预烧温度Th及保温时间,可以很容易地控制SrM磁粉的粒子大小及分布、形貌、结构和磁性。实验表明,用BaCl2及K2SO4作助熔剂时,可以制备出磁性很好的亚微米SrM磁粉:粒子尺寸0.3~0.5μm,σ16=74.4~79.3μWb.m/kg(σ16为Hm=1273kA/m时的磁化强度),HCJ=414~329kA/m。而用KCl及NaBO2.4H2O作助熔剂时,可以制备粒径均匀、直径厚度比(D/t)很大的扁平状六角形SrM磁粉。这种磁粉适宜于生产高性能的柔性粘结磁体。而前述的亚微米SrM磁粉适宜于生产高矫顽力的烧结磁体。 相似文献