Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin

Camptothecin, an anticancer component from Camptotheca acuminate, may interact with human serum albumin (HSA) at the subdomain IIA (site I), and then convert to its inactive form(carboxylate form). In this paper, the detailed electrochemical behaviors of camptothecin at a pyrolytic graphite electrode is presented. The interaction between camptothecin and HSA is also studied by electrochemical technique. By comparing with bovine serum albumin (BSA), which is highly homologous to HSA, we prove that camptothecin can specifically bind to HSA. Meanwhile, the inhibitory influence of sodium salicylate to this binding is also discussed.     

日本新农村运动对重庆农村人力资源开发的启示

日本新农村运动及其人力资源开发状况给重庆农村人力资源开发带来启示。借鉴日本的经验，重庆可以从发展教育、建设农民组织、激发村民积极性、健全社会保障体系、加强基础设施建设和发挥政府作用这几个方面着手，进行农村人力资源开发。     

开发老年人力资源 应对人口老龄化的挑战

我国在开发利用老年人力资源方面，由于缺少政策鼓励、社会服务和家庭支持，老年人就业中没有劳动合同保障、最低工资保证和劳动福利保护，直接影响了老年人力资源的开发利用。要尽快制定老年人力资源开发的政策法规，呼吁社会重视对老年人力资源的开发利用，适时推行灵活退休制度，把老年人才开发纳入人才资源开发的整体战略之中。     

Deprivation selectively modulates brain potentials to food pictures.

Event-related brain potentials (ERPs) were used to examine whether the processing of food pictures is selectively modulated by changes in the motivational state of the observer. Sixteen healthy male volunteers were tested twice 1 week apart, either after 24 hr of food deprivation or after normal food intake. ERPs were measured while participants viewed appetitive food pictures as well as standard emotional and neutral control pictures. Results show that the ERPs to food pictures in a hungry, rather than satiated, state were associated with enlarged positive potentials over posterior sensor sites in a time window of 170-310 ms poststimulus. Minimum-norm analysis suggests the enhanced processing of food cues primarily in occipito-temporo-parietal regions. In contrast, processing of standard emotional and neutral pictures was not modulated by food deprivation. Considered from the perspective of motivated attention, the selective change of food cue processing may reflect a state-dependent change in stimulus salience. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Review of Technology as symptom and dream.

Reviews the book, Technology as symptom and dream by Robert D. Romanyshyn (see record 1990-97140-000). This book is an empassioned call to reexamine the history of technology and to remember the desire that propelled it. Faced with the atom bomb and space flight, we can no longer ignore, Romanyshyn argues, the possibility of the final destruction of our planet. True to his vocation as a psychologist, Romanyshyn finds that the path toward preventing the suicide of mankind lies in re-examining, reflecting and retelling the story of our past and in understanding how it shapes our present and our future. He offers us a shift in perspective: maybe we have misunderstood what technology is all about. "Perhaps technology has been part of the earth's long history of coming to know itself, and perhaps in that effort we have been its servant. (...) On a dry African plain, in the silence of the early morning, one can still imagine technology as vocation, as the earth's call to become its agent and instrument of awakening. But in the shadows imagination falters and technology seems less the earth's way of coming to know itself and more the earth's way of coming to cleanse itself of us" (p. 3). Romanyshyn's book is biased, but biased in a positive way: he refuses the detached view of the uninvolved observer. The book speaks with passionate insight for the abandoned body and the repressed soul. Informed by the phenomenological critique of the scientific attitude, Romanyshyn attempts to recover the cultural history of consciousness and the lived body. He weaves a fascinating story that resonates with profound echoes from the past. He challenges the reader's presuppositions and our habitual modern ways of conceptualizing space, body and self. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

基于二元水循环模式的水资源评价理论方法

国内外流域水资源评价方法是随着水资源稀缺性的逐渐增强而不断发展的。时至今日，传统的水资源评价方法在描述人类活动干扰和满足不同层次水资源规划要求方面面临严峻挑战。本文提出了水资源全口径层次化动态评价方法，即以降水为资源评价的全口径通量，遵照有效性、可控性和可再生性原则对降水的资源结构进行解析，实现广义水资源、狭义水资源、径流性水资源和国民经济可利用量的层次化评价。在手段上，构建了由分布式水循环模拟模型与集总式水资源调配模型耦合而成的二元水资源评价模型，并将下垫面变化和人工取用水作为模型变量以实现动态评价。     

Cyclical changes in volatile acidic metabolites of human vaginal secretions and their relation to ovulation

The major volatile constituents in human vaginal secretions were identified. Data collected during the course of 29 cycles from 9 subjects showed that the nature and abundance of the vaginal organic constituents differed with respect to subject. Only 3 of 9 subjects investigated consistently had C₃-C₅ aliphatic acids; acetic acid was present in all subjects. Lactic acid was the major acidic compound consistently found in the vaginal secretion of all subjects near the time of ovulation. Cyclical changes in the acidic constituents were demonstrated.     

Psychoanalysis as a natural science.

Despite Freud's unwavering intention that psychoanalysis should conform to the requirements of a natural science, this aim has not been realized. Some analysts hold the aim to have been mistaken. Others believe it can and should be achieved, proposing that traditional metapsychology be replaced by a new conceptual framework utilizing modern concepts not available to Freud. Utilizing data obtained from current findings in developmental psychology based on direct observation of parent-child interaction as well as from therapeutic sessions, a possible framework is sketched using principles derived from ethology, control theory, and human information processing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Protective effect evaluation of free radical scavengers on UVB induced human cutaneous erythema by skin reflectance spectrophotometry

This paper assesses the suitability of UVB induced skin erythema measured by reflectance spectrophotometry in humans as a model for differentiating topical efficacy of free radical scavengers. Two different formulations (aqueous gels and O/W emulsions) of each active compound (tocopherol, tocopherol acetate, superoxide dismutase (SOD), glutathione, ascorbyl palmitate) were tested on healthy human volunteers before and after skin exposure to UVB radiation. Skin erythema was monitored by calculating erythema index values from the skin spectral data obtained using a reflectance spectrophotometer. The free radical scavengers tested were not able to inhibit UVB induced skin erythema from both formulations when they were topically applied before UVB irradiation. Applying the free radical scavenger formulations after skin exposure to UVB radiation, glutathione and SOD showed the best ability in inhibiting the induced erythema (percentage inhibition 53.3 and 41.6%, respectively from gels). Tocopherol and tocopherol acetate inhibited UVB skin erythema by 27% while ascorbyl palmitate showed a poor efficacy. For all the active compounds tested, no significant difference was observed comparing the results obtained from gels to those from emulsions. Liposomal gel formulations containing the free radical scavengers which showed the best activity (SOD and glutathione) were prepared and topically applied after skin exposure to UVB radiation. SOD and glutathione liposomal formulations were more effective than the corresponding conventional gels. The proposed model, if validated by further studies, could be useful for differentiating the effectiveness of free radical scavengers in inhibiting photoaging due to long-term sunlight skin exposure.     

Human quality control in naval air training.

"In training programs, whether these be military… or civilian… quality control requirements exist… . This paper describes an important instance of the application of psychological research methods to human quality control over a total training program… . Human quality control… should start with identification of graduates who have been unsuccessful on the job and work backwards to the determination of those minimum standards which will prevent the selection and/or graduation of potential failures… . minimum standards already installed and under investigation should reduce the number of unsatisfactory men reaching the fleet by about 50%." The study of minimum training standards is a continuing one. The procedures for translating criterion data into an effective quality control program are summarized in 5 steps. (PsycINFO Database Record (c) 2010 APA, all rights reserved)