飞行人员骨密度与内分泌调节关系的探讨

对37名骨密度(BD)低下的飞行员(实验组)和BD正常的48名飞行员、100名地面人员(正常对照组)进行了BD和血清TT_3、TT_4、TSH IRMA、CT、PTH、E_2和T放射免疫测定。结果显示,实验组BD均值明显低于对照组(p<0.01),血清TT_3、TT_4、CT、E_2(女性)和T(男性)均值与对照组比较,大多数年龄存在着显著或非常显著差异(p<0.05或p<0.01)。同时对飞行人员BD与几种内分泌激素关系进行了探讨。     

Hormonal Responses to Susceptible,Intermediate, and Resistant Interactions in the Brassica napus–Leptosphaeria maculans Pathosystem

Hormone signaling plays a pivotal role in plant–microbe interactions. There are three major phytohormones in plant defense: salicylic acid (SA), jasmonic acid (JA), and ethylene (ET). The activation and trade-off of signaling between these three hormones likely determines the strength of plant defense in response to pathogens. Here, we describe the allocation of hormonal signaling in Brassica napus against the fungal pathogen Leptosphaeria maculans. Three B. napus genotypes (Westar, Surpass400, and 01-23-2-1) were inoculated with two L. maculans isolates (H75 8-1 and H77 7-2), subsequently exhibiting three levels of resistance: susceptible, intermediate, and resistant. Quantitative analyses suggest that the early activation of some SA-responsive genes, including WRKY70 and NPR1, contribute to an effective defense against L. maculans. The co-expression among factors responding to SA/ET/JA was also observed in the late stage of infection. The results of conjugated SA measurement also support that early SA activation plays a crucial role in durable resistance. Our results demonstrate the relationship between the onset patterns of certain hormone regulators and the effectiveness of the defense of B. napus against L. maculans.     

Clinical Significance of Tumor Infiltrating Lymphocytes in Association with Hormone Receptor Expression Patterns in Epithelial Ovarian Cancer

Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes in tumors. Specifically, the presence of specific tumor-infiltrating lymphocytes (TILs) with particular hormone receptor expression is reportedly associated with breast cancer, however, this has not been revealed in epithelial ovarian cancer (EOC). Therefore, we investigated the association between hormone receptor expression and TILs in EOC. Here we found that ERα, AR, and GR expression increased in EOC, while PR was significantly reduced and ERβ expression showed a reduced trend compared to normal epithelium. Cluster analysis indicated poor disease-free survival (DFS) in AR+/GR+/PR+ subgroup (triple dominant group); while the Cox proportional-hazards model highlighted the triple dominant group as an independent prognostic factor for DFS. In addition, significant upregulation of FoxP3+ TILs, PD-1, and PD-L1 was observed in the triple dominant group compared to other groups. NanoString analyses further suggested that tumor necrosis factor (TNF) and/or NF-κB signaling pathways were activated with significant upregulation of RELA, MAP3K5, TNFAIP3, BCL2L1, RIPK1, TRAF2, PARP1, and AKT1 in the triple dominant EOC group. The triple dominant subgroup correlates with poor prognosis in EOC. Moreover, the TNF and/or NF-κB signaling pathways may be responsible for hormone-mediated inhibition of the immune microenvironment.     

新型防雷及抗干扰方法在电铲控制系统的应用

电铲是采区主要采掘设备,其弱电控制系统是电铲正常可靠运行的关键。由于雷击或电磁干扰造成弱电控制系统装置的损坏或工作异常等故障,已成为影响电铲安全正常运行的重要因素。针对现有电铲控制系统防雷抗干扰现状、存在的问题及影响,研究了一种新型防雷抗干扰方法,并分析了其在电铲弱电控制系统中的应用和实施效果。实际运行表明,新型防雷抗干扰方法能够有效提高电铲弱电控制系统防雷及抗干扰能力,对电铲及其他弱电控制系统防雷抗干扰的研究和应用具有积极的现实意义,且有着很好的推广价值。     

聚乙二醇化重组人生长激素的性质及活性

目的　研究聚乙二醇化重组人生长激素的性质及活性。方法　通过分子筛高效液相 (SizeexclusionHPLC)、毛细管等电聚焦 (CIEF)、圆二色谱 (CD)以及荧光光谱等方法检测单聚PEG- GH的纯度、等电点、二级结构以及分子构象 ;采用妊娠兔肝细胞放射受体分析法 (RRA)检测单聚PEG GH的体外受体亲和力 ,采用未成年去垂体大鼠体重增加法检测体内生物活性。结果　分子筛高效液相图谱上仅出现一个峰 ,表明样品纯度很高 ,等电点范围为 5 .1～ 5 .2 ,与未修饰的rhGH的等电点相一致 ;CD谱与荧光光谱均表明单个mPEG ALD的修饰对rhGH的二级结构以及分子构象没有明显影响 ;与未修饰的rhGH相比 ,单聚PEG GH体外受体亲和力明显降低 ;但体内作用时间更长 ,且更加有效。结论　此结果为进一步研究和开发长效重组人生长激素提供了理论依据。     

轴流压气机旋转失速建模与检测II: 基于北航低速压气机试验台的实验研究

轴流压气机旋转失速和喘振的提前检测对于提高压气机工作效率和稳定性具有重要的意义.本文以北京航空航天大学航空发动机重点实验室的低速轴流压气机实验台为研究对象,基于确定学习理论及动态模式识别方法,开展旋转失速初始扰动近似准确建模和快速检测研究.首先,在压气机机匣壁面周向布置多个动态压力传感器,获取压气机失速前和失速先兆的动态压力信号,基于确定学习理论对旋转失速初始扰动的内部系统动态进行建模;其次,基于以上建模,利用微小振动故障检测方法实现对旋转失速的离线和在线提前检测.实验结果表明,本文所提方法能够在不同转速情况下,提前0.3 s~1 s实现对旋转失速的实时在线检测.     

仪表联锁一体化控制单元(ITCC)在压缩机防喘振控制上的应用

介绍了基于PLC的压缩机一体化控制系统,PLC和现场总线系统(DCS)、安全仪表系统(SIS)、马达一体化控制系统(MCC)等信号之间的相互关系。主要论述了压缩机的防喘振控制理论,防喘振控制器的功能及防喘振控制在赛科乙烯装置裂解气压缩机的应用。     

连接管对调压室涌波水位和水锤压力的影响

在传统大波动过渡过程计算中,调压室底部连接管的影响往往是作为阻抗孔来考虑,在连接管较长的情况下,采用阻抗孔处理时而忽略了连接管的水体弹性,因而容易造成较大误差。通过建立考虑了连接管及不考虑连接管时的调压室节点数学模型,采用Gardel公式来处理调压室的阻抗系数,将调压室的阻抗系数变为负荷实际情况的动态阻抗系数,并结合具体工程实例来分析连接管的长度及管径的变化对调压室涌浪、蜗壳进口压力以及机组转速所产生的影响。研究结果表明,对于连接管较长的情况,应考虑到连接管的作用,为了能充分反射水锤,连接管的面积不宜过小。     

双机共用尾水调压室阻力系数试验研究

主要对水流在流入和流出调压室时,其流量比、阻抗孔面积和运行机组数目的变化对调压室阻力系数的影响开展了研究,并对双机共用尾水调压室的物理模型进行了水工试验。试验结果表明,调压室的阻力系数会随着流量比的增大和阻抗孔面积的减小而增大。其中,在分流工况时,双机运行的调压室阻力系数比单机运行的调压室阻力系数要大;在合流工况时,单机运行的调压室阻力系数与双机运行时的相差无几。试验结果可为类似型式的尾水调压室的设计与研究提供借鉴及参考。     

甬沪宁原油管道水击分析与超前保护

介绍全线的站场组成及其每个站场的输油泵的配备情况,分析甬沪宁原油输送管道可能运行的输油工况,介绍了用于水击分析时稳态极限工况的选取方法,并从可能引起水击发生的水击源、产生水击时工况、用于水击分析的管道瞬变过程的理论和甬沪宁原油输送管道的各个站场的边界条件的确定方面,全面阐述了对甬沪宁管线进行水击分析的过程,同时给出了两种水击工况下的计算分析结果。