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991.
In this paper, we consider software development project success and failure from the supplier's perspective. First we clarified concepts in order to be able to exclude review articles on in-house projects, continuous services, the customer's perspective, and software product development, with the aim of providing valid results for supplier firms. We divided success criteria into project success and project management (PM) success, and, in seven articles, identified three success criteria from the supplier's perspective: customer satisfaction, short-term business benefits, and long-term business benefits. In contrast, no definition of software development project failure was found. Articles were found in seven different journals, showing that knowledge on software development project success from the supplier's perspective is fragmented. This impedes the growth of knowledge on this topic.  相似文献   
992.
The growing number of company projects requires comprehensive management, project portfolio management (PPM), for strategic alignment and efficient use of resources. In parallel, companies face customers demanding higher value, and joint value creation with customers is considered a key success factor in the future. Project portfolios delivering products and services for customers implicate a link between PPM and an increased customer focus. Combining the research fields of marketing and PPM for the first time, this study proposes customer integration into PPM. I develop a framework describing the impact of customer integration into PPM on project portfolio success mediated through relationship value. Furthermore, the study describes relevant aspects for customer integration on the project portfolio level and identifies interfaces for cross-functional integration of a customer portfolio representative within the PPM process. The findings and limitations of this study are discussed, and further research is suggested.  相似文献   
993.
Project portfolio management is central to many organizations' strategic processes and requires consideration of multiple factors and the ability to envision alternative future consequences to support strategic project portfolio decision making. Complex project portfolios with multiple project interdependencies are characteristic of many project environments, yet existing methods do not provide the clear understanding of project interdependencies that is required.  相似文献   
994.
通过研究发现,成就动机的强弱与个体学生对待其学业的态度以及对待其人际交往圈的态度息息相关,甚至是决定其成功与否的关键因素.因此,应将成就动机的培养作为教学工作中重要的心理教育环节,通过提高教师素养,调整教学方式,引导学生正确地进行自我认知和自我评价,有效地激发学生的成就动机,从而塑造其高尚美好的人格.  相似文献   
995.
欧海燕 《化工之友》2008,27(15):108-109
目的观察异位妊娠中西医结合保守治疗疗效。方法对168例符合异位妊娠保守治疗条件者,临床检验无用药禁忌症,给予甲氨蝶呤肌肉注射,米非司酮口服并联合中药宫外孕方水煎服。结果145例治愈,治愈率为86.3%。结论此法对符合异位妊娠保守治疗条件者,用药简单,不良反应小,可避免手术创伤,患者易于接受,可以推广应用。  相似文献   
996.
针对福建电力用电信息采集系统中的GPRS公网终端出现的3A频繁认证现象进行阐述.GPRS公网终端的频繁认证增加了3A服务器的工作负荷,大量消耗了3A服务器的存储资源,并且降低了GPRS公网终端的通信成功率.通过现场测试,分析产生该问题的原因,提出对应的解决方案,取得明显的效果,提高了3A服务器的工作效率和GPRS公网终端的通信成功率.  相似文献   
997.
提出了小型断路器的可靠性故障模式和试验方法。以NDM1小型断路器为样本,按照产品标准规定的寿命指标、设定的操作失效率和瞬动保护成功率等级,验证了产品的可靠性。为探讨该断路器更高的可靠性水平,又在高于寿命指标和提高可靠性等级设定下进行了可靠性试验。分析了试验中暴露的产品薄弱点,从而提出进一步改进的方向。  相似文献   
998.
    
Gestational diabetes mellitus (GDM) causes both maternal and fetal adverse outcomes. The deregulation of microRNAs (miRNAs) in GDM suggests their involvement in GDM pathogenesis and complications. Exosomes are extracellular vesicles (EVs) of endosomal origin, released via exocytosis into the extracellular compartment. Through EVs, miRNAs are delivered in distant target cells and are able to affect gene expression. In this study, miRNA expression was analyzed to find new miRNAs that could improve GDM classification and molecular characterization. MiRNA were profiled in total plasma and EVs in GDM patients and normal glucose tolerance (NGT) women. Samples were collected at third trimester of gestation from two diabetes centers. MiRNA expression was profiled in a discovery cohort using the multiplexed NanoString nCounter Human v3 miRNA. Validation analysis was performed in a second independent cohort using RT-qPCR. A set of miRNAs resulted to be differentially expressed (DE) in total plasma and EVs in GDM. Among them, total plasma miR-222-3p and miR-409-3p were validated in the independent cohort. MiR-222-3p levels correlated with fasting plasma glucose (FPG) (p < 0.001) and birth weight (p = 0.012), whereas miR-409-3p expression correlated with FPG (p < 0.001) and inversely with gestational age (p = 0.001). The major validated target genes of the deregulated miRNAs were consistently linked to type 2 diabetes and GDM pathophysiology. MiR-222-3p and miR-409-3p are two circulating biomarkers that could improve GDM classification power and act in the context of the molecular events leading to the metabolic alterations observed in GDM.  相似文献   
999.
    
Gestational diabetes mellitus (GDM) increases risk of adverse pregnancy outcomes and maternal cardiovascular complications. It is widely believed that maternal endothelial dysfunction is a critical determinant of these risks, however, connections to maternal cardiac dysfunction and mechanisms of pathogenesis are unclear. Circulating extracellular vesicles (EVs) are emerging biomarkers that may provide insights into the pathogenesis of GDM. We examined the impact of GDM on maternal cardiac and vascular health in a rat model of diet-induced obesity-associated GDM. We observed a >3-fold increase in circulating levels of endothelial EVs (p < 0.01) and von Willebrand factor (p < 0.001) in GDM rats. A significant increase in mitochondrial DNA (mtDNA) within circulating extracellular vesicles was also observed suggesting possible mitochondrial dysfunction in the vasculature. This was supported by nicotinamide adenine dinucleotide deficiency in aortas of GDM mice. GDM was also associated with cardiac remodeling (increased LV mass) and a marked impairment in maternal diastolic function (increased isovolumetric relaxation time [IVRT], p < 0.01). Finally, we observed a strong positive correlation between endothelial EV levels and IVRT (r = 0.57, p < 0.05). In summary, we observed maternal vascular and cardiac dysfunction in rodent GDM accompanied by increased circulating endothelial EVs and EV-associated mitochondrial DNA. Our study highlights a novel method for assessment of vascular injury in GDM and highlights vascular mitochondrial injury as a possible therapeutic target.  相似文献   
1000.
    
Clinical and animal studies suggest that paternal exposure to adverse environments (bad living habits and chronic stress, etc.) has profound impacts on offspring development; however, the mechanism of paternal disease has not been clarified. In this study, a meta-analysis was first performed to suggest that paternal exposure to nicotine, ethanol, or caffeine is a high-risk factor for adverse pregnancy outcomes. Next, we created a rat model of paternal nicotine/ethanol/caffeine mixed exposure (PME), whereby male Wistar rats were exposed to nicotine (0.1 mg/kg/d), ethanol (0.5 g/kg/d), and caffeine (7.5 mg/kg/d) for 8 weeks continuously, then mated with normal female rats to obtain a fetus (n = 12 for control group, n = 10 for PME group). Then, we analyzed the changes in paternal hypothalamic–pituitary–adrenal (HPA) axis activity, testicular function, pregnancy outcomes, fetal serum metabolic indicators, and multiple organ functions to explore the mechanism from the perspective of chronic stress. Our results demonstrated that PME led to enhanced paternal HPA axis activity, decreased sperm quality, and adverse pregnancy outcomes (stillbirth and absorption, decreased fetal weight and body length, and intrauterine growth retardation), abnormal fetal serum metabolic indicators (corticosterone, glucolipid metabolism, and sex hormones), and fetal multi-organ dysfunction (including hippocampus, adrenal, liver, ossification, and gonads). Furthermore, correlation analysis showed that the increased paternal corticosterone level was closely related to decreased sperm quality, adverse pregnancy outcomes, and abnormal offspring multi-organ function development. Among them, the decreased activity of the glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis may be the main mechanism of offspring development and multi-organ dysfunction caused by PME. This study explored the impact of common paternal lifestyle in daily life on offspring development, and proposed the GC-IGF1 programming mechanisms of paternal chronic stress-induced offspring dysplasia, which provides a novel insight for exploring the important role of paternal chronic stress in offspring development and guiding a healthy lifestyle for men.  相似文献   
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