鳄鱼皮制革工艺探讨

介绍了鳄鱼皮制革的若干技术要点 ,及漂白退色的工艺。     

A new method for skin care product evaluation based on the laser Doppler imaging technique

Laser Doppler perfusion imaging was used to assess the vasoactive effect of a cosmetic product on a cutaneous inflammation model: erythema induced by methyl nicotinate. Measurements were carried out on ten healthy volunteers after a rest in an environmental controlled room, and trials were performed on the ventral surface of the forearms. Recordings of cutaneous perfusion were made every 10 min after application of the vasodilator. The decrease in the highest value of perfusion on the test site was significantly higher with the cosmetic compared to the control site 30 min after its application. Fifty minutes after application, the difference between the test and control sites was 53%.     

无限导流垂直裂缝井的一种快速试井分析方法

本利用椭圆流动模型的解的计算公式，计算出了均质及双重介质油藏中无限导流垂直裂缝井试井分析的典型曲线，本还利用拉氏数值正演和拉氏数值反演技术，考虑了井筒存储和表皮效应对无限导流垂直裂缝井的试井分析典型曲线的影响，并对各种情况下的典型曲线特征进行了分析。     

Effect of skin addition on the technological properties of comminuted chicken meat emulsions

Possibility of using skin supplement as collagen raw material (substituting leg muscles) in highly comminuted sausages made from breast muscles was investigated. It was found that 5% skin added to the comminuted breast muscles resulted in the collagen content equal to that obtained with 40% leg muscles. Addition of 5% skin to the breast muscles decreases emulsifying capacity of protein extracts but increases thermal stability, and changes the flow curve of meat emulsions more than the addition of dark muscles. The skin used instead of leg muscles does not change sausage binding (shear force) and overall sensory value, but reduces water-holding capacity and palat-ability of sausages.     

Les enzymes de l'espace extra-cellulaire du stratum corneum

Bien que le stratum corneum soit composé de cellules ‘mortes’, il est le siège d'une activité métabolique très importante. Mais, contrairement à la plupart d'autres tissus, cette activité a la particularité d'étre extra-cellulaire. Elle est due à des enzymes excrétées par les Corps d'Odland avec les bicouches céramidiques. Ces enzymes sont des hydrolases, elles sont identiques ou très proches de celles des lysosomes. Les principales activités observées correspondent à une (ou des) glycosidase(s), une phospholipase, une sphingomyélinase, une phosphatase, une (ou des) estérase(s), des sulfatases, des protéases. Comme les hydrolases des lysosomes, elles semblent peu spécifiques. Ce pool enzymatique pourrait jouer plusieurs rôles fondamentaux, notamment: 1. La transformation des bicouches gluco-céramidiques en bicouches ceramidiques plus lipophiles; 2. L'élimination de la membrane plasmique, dont certains produits du catabolisme, comme les acides gras et les céramides, peuvent être intégrés aux bicouches céramidiques; 3. La diminution de la cohésion entre les cornéocytes; 4. La protection contre l'intrusion de corps étrangers. Comme tout système enzymatique, les hydrolases extra-cellulaires, sont certainement soumises à des régulations. Plusieurs de ces régulations sont envisagées. A partir de considérations d'enzymologie, le pH de la base du stratum corneum peut être estiméà environ 5. En cosmétologie, les enzymes du stratum corneum sont mises à contribution pour rendre actifs des précurseurs. L'étude des conséquences des modifications de l'activité enzymatique sur l'état de la peau pourrait constituer une future voie de recherche extrêmement prometteuse.     

复合双孔介质油藏中压力分布的相似结构

文章首先建立了复合双孔介质油藏在考虑井筒储集和表皮效应和三种外边界(无穷大、定压、封闭)条件下的试井分析模型;利用Laplace变换,求得了其在Laplace空间中的无量纲压力分布的精确解;经过分析其解式的特征,发现了它们在三种外边界下的解式之间具有相似结构,并作了进一步应用的讨论。这项研究,可以极大地方便试井分析的软件编制,也是对石油渗流理论的进一步发展。     

本钢冷轧厂平整机组AUTOMAX控制系统

介绍了引进的美国Ｒｅｌｉａｎｃｅ公司生产的ＡＵＴＯＭＡＸ控制系统的硬件总体结构及软件支持中所采用的三种主要程序。直流调速系统是全数字式调节系统，电机调速范围宽，电机的电流，电压和速度控制精度高，电流环，速度环的动态时间快，系统动，静态性能好且稳定可靠，系统故障诊断方便，带钢的延伸率控制精度高。     

Studies on the interaction of p-phenylene diamine with phospholipids

In vitro studies on the interaction of phospholipids with p-phenylene diamine, a major component of hair dyes, were undertaken. Thin layer and molecular sieving chromatography along with phosphorus estimation and spectral characterization suggested the possibility of p-phenylene diamine and its biotransformation products combining with lipophilic biomolecules.     

Efficient Transdermal Delivery of DNA Nanostructures Alleviates Atopic Dermatitis Symptoms in NC/Nga Mice

DNA nanostructures have been widely studied in biomedical research contributing to targeted treatment of chronic diseases. The immunostimulatory X_L‐DNA nanostructures of X‐shaped oligodeoxynucleotides complex are previously reported, activating toll‐like receptor9 in dendritic cells. This study examines whether the X_L‐DNA could be therapeutically applied to treat immune diseases such as atopic dermatitis. To optimize topical delivery, liposome‐encapsulated X_L‐DNA (Lipo‐X_L‐DNA) is generated using emulsion transfer method with lipid layers composed of 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine, 1,2‐dioleoyl‐sn‐glycero‐3‐phospho‐(1′‐rac‐glycerol), and cholesterol. Size distribution of Lipo‐X_L‐DNA ranges around 90–160 nm with mean diameter of 115.44 ± 18.72 nm. The morphology is confirmed by transmission electron microscope. Zeta potential is ?28.59 mV. Confocal microscopy shows that Lipo‐X_L‐DNA is efficiently delivered into epidermis and dermis. Topical application of Lipo‐X_L‐DNA effectively alleviates atopic dermatitis symptoms in mice, as shown by dermatitis score, histological evaluation, and serum immunoglobulin E levels. RNA‐seq analysis confirms that Lipo‐X_L‐DNA reduces pro‐inflammatory products, but increases epidermal barrier homeostasis factors in atopic dermatitis lesions. Lipo‐X_L‐DNA orchestrates immune balance by downregulating Th2 immunity, but upregulating Th1 immunity. Collectively, liposome encapsulation enables efficient transdermal delivery of X_L‐DNA, for an effective treatment of atopic dermatitis in mice. The results provide a promising therapeutic strategy using X_L‐DNA nanostructures to treat immune‐compromised diseases.