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在环境监测期间,经常发现设计文件中包含的环境保护措施和设施与环境影响评估报告和批准的文件不相符,经常会出现固体废物和一些存在安全隐患的废弃物放在一起的问题,针对这些问题应采取相应的措施,将固体废物和存在安全隐患的废弃物分开放置,合理利用土地,把施工期间污染物对环境造成的影响降到最低。 相似文献
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This treatment describes the details of a systematic protocol useful for performing optimal automated process fault analysis. This implementation generalizes the underlying Boolean logic version of the Method of Minimal Evidence (MOME) developed previously to a highly comprehensive algorithm for performing model-based fault diagnostics. This generalization allows for a more compact treatment of potential single and multiple fault situations, at all levels of possible diagnostic resolution, with both elegant and efficient uniform sensor validation and proactive fault analysis (SV&PFA) diagnostic rules for diagnosing those situations. This Assumption State Differences (ASD) Protocol version of the MOME algorithm thus automates the diagnostic reasoning necessary to continuously perform optimal process fault analysis so that only the underlying well-formulated models are required to achieve such performance. Using this algorithm consequently directly simplifies the solution of the more complicated problem of automated process fault analysis into the much more tractable, and incrementally solvable, problem of adequately modeling normal process operations. 相似文献
997.
Metastatic melanoma accounts for the highest number of skin cancer-related deaths. Traditional treatments are ineffective due to their inability to induce tumor regression at a high rate. Newer treatments such as immune checkpoint inhibitors (ICI), targeted therapy (BRAFi and MEKi), and T cell receptor (TCR)-engineered T cells aim to increase the ability of the host immune system to recognize and eradicate tumors. ICIs inhibit negative regulatory mechanisms and boost the antitumor activity of the host’s immune system, while targeted therapy directed against aberrant signaling molecules (BRAF and MEK) will block the uncontrolled proliferation and expansion of melanomas. The basis of the TCR-engineered T cell strategy is to transduce host T cells with antigen-specific TCRα/β chains to produce high-affinity T cells for tumor-associated antigens. TCR-transgenic T cells are expanded and activated ex vivo and reinfused into patients to increase the targeting of cancer cells. While these treatments have had varyingly favorable results, their efficacy is limited due to inherent or acquired resistance. Various mechanisms explain melanoma immune-resistance, including the loss or downregulation of the MCH/peptide complex, aberrant activity of signaling pathways, and altered dynamics of apoptotic machinery. Collectively, these mechanisms confer melanoma resistance to apoptotic stimuli delivered by T cells despite a fully functional and effective antitumor immune response. Identification of biomarkers, combination treatment, and the use of CAR T cells are among the approaches that can potentially circumvent melanoma’s resistance to immunotherapy. 相似文献
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《Ceramics International》2016,42(14):15269-15273
Yohen Tenmoku is a kind of famous black glazed Jian bowls made in ancient China. Here, imitations of Oil Spot Yohen Tenmoku were sintered at about 1280 °C in a shuttle kiln with oxygen flow. Microstructure characteristics and chemical compositions were investigated by a combination of X-ray based and photon based characterization methods. The results showed that quartz and mullite were the main crystalline phases in the bowl bodies. At the glaze surface of the bowl, the highly reflective red iridescence and the silvery appearance of Oil Spot patterns were resulted from the precipitation of hematite (α-Fe2O3) crystals. A detailed study has revealed the partially ordered microstructure within one Oil Spot which produced the striking optical effects. 相似文献
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提升电镀行业环境污染防治能力,既要强调提高生产设备和治污设施等硬件,更要着眼于企业环境管理制度等软件。指出了当前企业在建设环境管理制度方面存在的问题。从企业自身及监管部门两个角度,阐述了企业建设环境管理制度应遵循的原则、重点建设内容和需要注意的一些问题,介绍了一些值得推广的措施。 相似文献