120 kt/a硫磺制酸水管锅炉改造为火管锅炉的技术总结

介绍FRS-12S-14.5/3.82-450型余热水管锅炉以较少的投资、较少的工程量、较短的施工周期改造成QF35/1050-14.2-3.82/450型火管锅炉,使热力系统满足了120kt/a硫磺制酸装置的工艺要求。改造后系统运行平稳,运行率提高,维护费用减少,生产成本降低,解决了水管锅炉因换热管束爆管导致锅炉腐蚀及烟气泄漏造成的环境污染等问题。     

Transport properties of 1,1,1,2-tetrafluoroethane (R134a)

New equations for the thermal conductivity and the viscosity of R134a that are valid in a wide range of pressures and temperatures are presented. They were obtained through a theoretically based, critical evaluation of the available experimental data, which showed considerable inconsistencies between data sets, in particular in the vapor phase. In the critical region the observed enhancement in the thermal conductivity is well represented by a crossover model for the transport properties of fluids. Since thermodynamic properties enter into the calculation of the critical enhancement of the transport properties, a new fundamental equation for the critical region was developed also.Paper dedicated to Professor Joseph Kestin.     

ZY6400型液压支架多通块的改型设计

针对多通块原设计中的整体式结构所带来的工艺复杂,产品合格率低,制造成本高等弊端,将其改型为用螺栓联接上下2片的分体式结构,收到了良好的效益。     

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Lung cancer is the leading cause of cancer death worldwide. miR-199a, which has two mature molecules: miR-199a-3p and miR-199a-5p, plays an important biological role in the genesis and development of tumors. We collected recent research results on lung cancer and miR-199a from Google Scholar and PubMed databases. The biological functions of miR-199a in lung cancer are reviewed in detail, and its potential roles in lung cancer diagnosis and treatment are discussed. With miR-199a as the core point and a divergence outward, the interplay between miR-199a and other ncRNAs is reviewed, and a regulatory network covering various cancers is depicted, which can help us to better understand the mechanism of cancer occurrence and provide a means for developing novel therapeutic strategies. In addition, the current methods of diagnosis and treatment of lung cancer are reviewed. Finally, a conclusion was drawn: miR-199a inhibits the development of lung cancer, especially by inhibiting the proliferation, infiltration, and migration of lung cancer cells, inhibiting tumor angiogenesis, increasing the apoptosis of lung cancer cells, and affecting the drug resistance of lung cancer cells. This review aims to provide new insights into lung cancer therapy and prevention.     

The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype

Nicotine exposure either from maternal cigarette smoking or e-cigarette vaping is one of the most common risk factors for neurodevelopmental disease in offspring. Previous studies revealed that perinatal nicotine exposure programs a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE) in postnatal life, yet the underlying mechanisms remain undetermined. The goal of the present study was to determine the regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps. All experiments were conducted in offspring pups at postnatal day 9 (P9). Perinatal nicotine exposure significantly enhanced expression of miR-181a but attenuated autophagy-related protein 5 (ATG5) mRNA and protein levels in neonatal brains. Of interest, miR-181a mimicking administration in the absence of nicotine exposure also produced dose-dependent increased hypoxia/ischemia (H/I)-induced brain injury associated with a decreased ATG5 expression, closely resembling perinatal nicotine exposure-mediated effects. Locked nucleic acid (LNA)-miR-181a antisense reversed perinatal nicotine-mediated increase in H/I-induced brain injury and normalized aberrant ATG5 expression. In addition, nicotine exposure attenuated a long non-coding RNA (lncRNA) H19 expression level. Knockdown of H19 via siRNA increased the miR-181a level and enhanced H/I-induced neonatal brain injury. In conclusion, the present findings provide a novel mechanism that aberrant alteration of the H19/miR-181a/AGT5 axis plays a vital role in perinatal nicotine exposure-mediated ischemia-sensitive phenotype in offspring and suggests promising molecular targets for intervention and rescuing nicotine-induced adverse programming effects in offspring.     

批量制作座牌方法探究

在举办大型会议或培训班时,为便于管理,常需制作参加人员的座牌。如果只是按照一般方法来制作,工作量大还容易出错。本文则突破思维定式,巧妙地利用Word软件的文本框和页面设置,通过邮件合并功能,实现了座牌的批量制作。     

旋流器组粒度分级原理及粒度控制技术

探索选矿厂的磨矿－ 分级过程的工作机理。并重点探讨旋流器组的粒度分级原理及粒度控制技术的实施方法。把旋流器组作为１ 个集工艺操作、过程检测控制及机电设备启停为一体的综合自动化控制系统。提出集散系统为基础的旋流器组控制系统的设计原理及系统构成。     

一种新的强噪声环境下的语音增强算法

针对强噪声环境下语音增强中噪声估计和先验信噪比估计算法导致的语音失真和音乐噪声的问题,利用语音和噪声的统计模型的对称性得到一种噪声幅度的估计值为参考,提出了一种噪声估计算法,改进了先验信噪比估计算法,形成了一种新的增强算法,适用于强噪声环境下的语音增强。由仿真实验给出的客观评分看出,在0 dB乃至－5 dB条件下,给出信噪比估计算法能够有效减小信号失真,基本上没有残留音乐噪声。