苦瓜绿茶口含片的研制

目的优化苦瓜绿茶口含片的制备工艺。方法以苦瓜为主要原料通过醇提法制备苦瓜浸提物,再利用苦瓜浸提物为主要原料,并添加速溶绿茶粉、木糖醇和玉米淀粉及其他辅料,经混合、制粒、干燥、压片等工序,通过正交试验筛选并获得苦瓜绿茶含片的最佳配方和制备工艺。结果苦瓜浸提物在料液比1:20,温度90℃的醇溶液中浸提4 h为其最佳浸提条件;以苦瓜浸提物0.3 g,速溶绿茶粉0.1 g,填充剂(玉米淀粉:β-环状糊精=1.5:0.8)1.5 g,木糖醇3.0 g为原料,并经55℃干燥可获得新型苦瓜绿茶口含片。结论本研究将苦瓜浸提物与速溶绿茶粉相结合,通过正交试验筛选并获得具有表面光滑美观且食用方便的新型苦瓜绿茶复合营养含片的最佳配方和制备工艺。     

单冲式压片机发展现状及趋势

以小型单冲式压片机为例,介绍了单冲式压片机的基本结构组成、工作原理及工作过程,阐述了国内外单冲式压片机的发展现状,同时根据其发展现状分析了目前单冲式压片机所存在的主要缺陷,并指明了其发展趋势。     

基于Pro/E的压片机参数化设计

利用Pro/E参数化设计功能及其二次开发工具Pro/Toolkit;以VS2008为开发平台,采用面向对象和可视化编程技术,以动态链接库的形式实现了在Pro/E平台下压片机零部件交互式参数化设计的方法.     

绍兴传统石亭调查与研究

绍兴以“水乡”和“石乡”闻名于世.在绍兴石桥被广泛研究的同时,绍兴石亭的研究却成为一大空白.或精致或简朴的绍兴石亭,与水乡人们的生活息息相关,同时也是构成水乡景色的重要点缀.而随着城市的发展,石亭正在从人们视线中消失.文中笔者通过实地调研,从古亭的选址、造型,以及文化角度,对1949年以前建造的具有绍兴传统特色的石亭,进行简单的介绍以及粗浅的总结.     

低糖余甘含片的研制

通过湿法颗粒法生产低糖余甘含片,并对含片的配方和一些影响产品质量的工艺及参数进行研究。结果表明,以余甘子提取物及赤藓糖醇为主要原料,以酒精为湿润剂,再添加适量的添加剂及食用香精,可制得有余甘子风味、口感好、硬度适中的低糖余甘含片。     

马齿苋保健含片生产工艺的研究

以马齿苋浓缩汁、麦芽糖醇、山梨糖醇为主要原料，添加一定量耐酸CMC、柠檬酸、薄荷等辅料，经混合、造粒、干燥、压片等工序，制成了低热量、具有保健功能的马齿苋含片。     

The necrogeography of pet memorial spaces: pets as liminal family members in contemporary japan

ABSTRACT

This article investigates how pets are included or excluded in the human necral landscapes of contemporary Japan. Their placement in mortuary spaces reflects the pets' paradoxical position as hybrids between humans and other nonhuman animals. Since the beginning of the pet boom in the 1990s, a growing number of Japanese pet owners consider their beloved pets family members during their lifetime and feel that they should hence be treated in death like a human. Paralleling changes in human mortuary practices in the modern period, many changes have occurred in mortuary practices involving pets: pets are buried and memorialized with Buddhist rituals, cremation has become the preferred method of disposal for pet bodies, funeral options have become more individualized, pet cemeteries are ubiquitous in the urban landscape, and joint human—pet burials are gaining currency. The inquiry focuses on two examples: the memorialization of pets in the home and the interment of pet cremains in cemeteries. Despite a greater sense of inclusion, contemporary mortuary practices place pets in a liminal position between animals and humans, indicating their status as marginal, temporary family members.     

Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics

Objective: To mask the bitterness of Chlorpheniramine Maleate via encapsulating drug into Eudragit EPO microparticles, and then incorporate these microparticles into orally disintegrating films (ODF) and orally disintegrating tablets (ODT) for pediatric uses.

Methods: Spray drying of water-in-oil emulsion was utilized to encapsulate Chlorpheniramine Maleate into Eudragit EPO microparticles. Based on an orthogonal experimental design L₉ (3³), polynomial regression models were developed to evaluate correlation between microparticle properties (encapsulation efficiency and drug release) and variables (X₁: weight ratio of polymer to drug, X₂: volume ratio of oil to water and X₃: Q-flow of spray dryer). ODF and ODT formulations were evaluated including weight variation, content uniformity, tensile strength, disintegration time, friability and dissolution profiles. The bitterness taste test was evaluated in 10 adult volunteers.

Results and discussion: From polynomial regression analysis, the best values of variables leading to the optimized microparticles were X₁?=?10, X₂?=?3 and X₃?=?45. The optimized microparticles were incorporated into ODF and ODT with satisfactory weight and drug content uniformity, and acceptable physical strength. Both dosage forms disintegrated immediately (less than 40?s) in simulated saliva solutions. The outcome of taste-masking test indicated that microparticles alleviated drug bitterness significantly; bitterness was not discernible with microparticles incorporated in ODT, whereas only slight bitterness was detected from microparticles incorporated into ODF.

Conclusion: Both ODF and ODT are shown to be suitable vehicles for taste masked Chlorpheniramine Maleate microparticles with potential for pediatric uses.     

Characteristics of Tableted Roselle (Hibiscus sabdariffa Linn.) with Addition of Sodium Starch Glycolate

The focus of this research is to study the characteristics of tablets produced from the binary powder mixture of Roselle (Hibiscus sabdariffa Linn.) and sodium starch glycolate (SSG) powders. The experimental parameters studied were the compaction pressure and the mass composition. The findings indicated that the increase of compaction pressure increased the tensile strength of tablets until a limiting value was reached. On the other hand, as the compaction pressure increased, the porosity of tablets decreased to a minimum value. The elastic recovery of tablets slightly decreased in some results. The increase in compaction pressure also increased the dissolution time of tablets up to a maximum value. The increase of SSG composition decreased the tensile strength of tablets to a certain amount. The dissolution time of tablets also reduced when the percentage of SSG increased. Subsequently, under the same compaction conditions, the increase of SSG composition increased the porosity and the elastic recovery of tablets until the limiting values were achieved.     

Preparation of (S)‐ibuprofen‐imprinted polymer and its molecular recognition study

Two molecularly imprinted polymers (MIPs) were prepared using (S)‐ibuprofen as the template molecule as well as methacrylic acid (MAA) or 4‐vinylpyridine and ethylene glycol dimethacrylate (EGDMA) as the functional monomer and crosslinker, respectively. Free radical polymerization was carried out at 4°C under ultraviolet (UV) radiation. The MIPs thus obtained were ground into 25–44 μm, which were slurry packed into analytical columns. The template molecules were removed by acetic acid/methanol solution (1:9, v/v). high‐performance liquid chromatography (HPLC), with UV detection, was used to evaluate the binding performance of the MIP for the template. The selectivity of (S)‐ibuprofen and naproxen on the host–guest system were assessed using acetonitrile‐based mobile phases. The limits of detection of ibuprofen and naproxen were found to be 0.1844 mmol/L and 0.3264 mmol/L, while the limits of quantitation were 0.6262 mmol/L and 1.0909 mmol/L, respectively. The stationary phase was applied successfully to the commercial tablet analysis. Ibuprofen and naproxen were extracted from tablets with acetonitrile; analysis results showed a good relative standard deviation (RSD) of 0.81–1.24% and accuracy from ?4.01 to +2.98% for ibuprofen as well as an RSD of 0.59–0.86% and accuracy from ?4.01 to ?2.01% for naproxen. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 2972–2979, 2006