Optimal Control of the Primary Drying Stage of Freeze Drying of Solutions in Vials Using Variational Calculus

The problem of operating freeze drying of pharmaceutical products in vials placed in trays of a freeze dryer to remove free water (in frozen state) at a minimum time was formulated as an optimal control problem. Two different types of freeze dryer designs were considered. In type I freeze dryer design, upper and lower plate temperatures were controlled together, while in type II freeze dryer design, upper and lower plate temperatures were controlled independently. The heat input to the material being dried and the drying chamber pressure were considered as control variables. Constraints were placed on the system state variables by the melting and scorch temperatures during primary drying stage. Necessary conditions of optimality for the primary drying stage of freeze drying process in vials are derived and presented. Furthermore, an approach for constructing the optimal control policies that would minimize the drying time for the primary drying stage was given. In order to analyze optimal control policy for the primary drying stage of the freeze-drying process in vials, a rigorous multi-dimensional unsteady state mathematical model was used. The theoretical approach presented in this work was applied in the freeze drying of skim milk. Significant reductions in the drying times of primary drying stage of freeze drying process in vials were obtained, as compared to the drying times obtained from conventional operational policies.     

CSTN-LCD用铬版清洗效果的改善

利用铬版清洗机对CSTN-LCD用铬版进行清洗处理,分析了清洗过程中出现的铬层脱落现象,铬层脱落与轴向喷射压力和水平切力密切相关,通过调整转速和喷射压力探索了安全使用条件:在转速不超过1000r/min,喷射压力低于0.5×105Pa的情况下使用铬版清洗机进行清洗是相对安全的。同时采用预清洗处理的方法满足清洁要求,使换线时间由平均3h缩短到平均1h以内,年产能提高270000片。     

Fifty Years On: Brown v. Board of Education and American Psychology, 1954-2004 An Introduction.

Introduces the current issue of the American Psychologist, which examines the ramifications of the Brown vs. Board of Education decision and its sequelae over the last 50 years, with a special focus on the mixed role of psychological research and practice. Despite the great strides toward a more just society since May 17, 1954, inequities remain in schooling, in social relations, and in economic opportunity. How will history judge American psychology 50 years from now vis-a-vis the possibilities it helped create via Brown? The articles in this special issue suggest several important directions of research and action our field will need to take if the verdict of history is to be a positive one. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

双级染料激光放大器泵浦能量分配的数值研究

用染料激光放大器的横向稳态泵浦理论，对不同的入射光能量选择不同的增益计算方法，研究了双级染料放大器的泵浦能量分配比例、泵浦光总能量和信号光能量大小对激光增益的影响。计算结果表明，对于其他参数确定的放大系统，存在着最佳的泵浦能量分配比例，可获得最大增益输出。通过自编程序的计算，可方便地找出特定系统泵浦能量分配比例的最佳值。     

从"天人合一"到"物我合一"——设计艺术中我国观念的转化

通过我国设计艺术中人与自然以及人与物古今观念的对比，试图分析这种观念的转化产生的深层社会背景和对设计的影响。     

套保稠油油田火烧油层可行性分析

从火烧油层的筛选标准、实际地质条件及室内物理模拟实验入手，对该油田火烧可行性进行了分析。分析结果认为，套保油田进行火烧总体上是可行的，在实际火烧时应避开底水的影响，火烧区域应选在构造高部位或仅烧其主力层。     

掺气减蚀保护作用的新概念

利用针式掺气流速仪测量原型和模型掺气浓度场、流速场，气泡尺寸及其概率分布的研究成果表明，原型水流韦伯数高，形成微小气泡的能力比模型强，气泡上浮慢，接近底部的小尺寸气泡概率及掺气浓度比模型大。初步研究认为：0.2mm或0.5mm以下的微小气泡在掺气减蚀中起着主要作用，可能只要很小掺气浓度即可达到掺气减蚀的效果。因此以小尺寸气泡的掺气浓度，作为判断掺气减蚀保护作用的指标将更为准确。     

大型连杆流线简易试验方法

介绍了一种大型连杆流线的简易试验方法及其评价原则。该方法可清晰显示流线，并适合任何尺寸和形状的锻造连杆的流线试验。     

微带型Wilkinson功分器设计与实现

小型低功耗器件是射频电路设计的研究热点,而微带技术具有小型化低功耗的优点,为此在介绍微带型Wilkin-son功分器工作原理的基础上,使用基于矩量法的ADS软件设计、仿真和优化计算相关数据参数,并制作了一个微带功分器实例,最后对加工的样品进行实测,获得与仿真值吻合较好的预期结果。     

Estimation and Optimization of the Principal H-Maser Parameters

The scale along the coordinate axes in the equations of motion hitherto used for an H-maser (in relative units) is shown to depend on Q as the quality factor for an H-maser. This hinders both analysis of the operation of the H-maser and optimization of its parameters. The modified equations of motion proposed here do not have that shortcoming. We determine the atomic flux into the bulb that gives the H-maser the best metrological characteristics.