北京新建筑地域性表达倾向

梳理了北京2000年以后建成的若干新建筑,依据地域性表达的程度和方式总结出3种较明显的倾向;通过对3种倾向的分析与归纳,反思了北京新建筑中地域性缺位问题,探讨了地域性表达的解决办法。     

C21甾苷提取方法的研究

为建立萝摩科植物及相应的保健产品中C21甾苷的定量方法，本文首先进行各咱提取方法的探讨。将用于强心苷薄层层析量显色的2-去氧糖反应进行了改进，作为进行各种提取方法C21甾苷相对含量比较的方法。根据C21甾苷的结构，选用了11种萃取剂进行了提取实验，并探讨了原料粉碎度、提取时间等其它条件对提取效果的影响，最终确定了C21甾苷的提取方法。     

MIKE SHE分布式水文模型在广东省中小河流洪水预报中的应用展望

中小河流急需提高洪水预报的有效性与及时性。 MIKE SHE是基于物理过程的分布式水文模型,具有高度灵活性、操作简单、应用范围广泛等特点。该文在分析中小河流洪水预报研究现状的基础上,提出MIKE SHE在广东省中小河流洪水预警预报中的应用展望。     

运用SW6进行双管板换热器管板的计算

由于ＳＷ６－９３（ＳＷ６－１９９８）软件包没有双管板换热器管板的计算模块，因此在设计计算时，我们将双管板换热器分成几个单管板换热器进行计算。几年来设计了数十台固定双管板换热器（卧式、立式）和Ｕ形管双管板换热器，下面介绍分解模式。     

Agglomeration and relocation: Manufacturing plant relocation in Korea

This study investigates the magnitude of localization economies by analysing the relocation pattern of Korean establishments in the manufacturing sector. Relocation of establishments is identified by their move across the border of wards, counties, or cities and distinguished between beyond and within their workers' commuting distance. It seems that relocation beyond commuting distance costs more than that within commuting distance since the former includes additional costs related with searching for, hiring, and training new workers. Key findings of this paper show that external benefits from agglomeration are large enough to be recognized by manufacturers through relocation beyond the border of their workers' commuting area. When the own industry's share of employment in all manufacturing industries becomes doubled through relocation, the probability for establishments to relocate over a long distance across the boundary of their workers' commuting area rises by 17 per cent. The results for sub‐samples divided by the age of establishments show that older establishments are more likely to relocate over a long distance to an area with disproportionate presence of establishments in the same industry. These results seem to fit product life cycle theory by Duranton and Puga. As the production process of the product becomes standardized, the firms producing that product tend to relocate to the specialized area where they can reduce the production costs by increasing dependence on the existing intermediate input suppliers, who are more likely to appear in a more specialized area.     

Long Non-Coding RNAs and p53 Regulation

The advent of novel and high-throughput sequencing (next generation) technologies allowed for the sequencing of the genome at an unprecedented depth. The majority of transcribed RNAs have been classified as non-coding RNAs. Among them, long non-coding RNAs (lncRNAs) are emerging as important regulators in many biological processes. Here, we discuss the role of those lncRNAs which are under the control of p53 or that are able to regulate its activity, due to the central role of p53 pathway in many conditions. We also briefly discussed the emerging need of having novel strategies and computational tools to completely unravel the multifaceted roles of lncRNAs and to pave the way to the development of novel diagnostic and therapeutic applications based on these peculiar molecules.     

符合FDA 21 CFR Part 11条款的系统搭建与验证

根据FDA21 CFR Part 11条款的规范要求,在色谱仪器综合系统中,建立符合该条款的系统并对其进行验证,并对过程中出现的问题进行总结。使系统达到精确、可靠、持续稳定,具有识别非法记录或被篡改记录的能力。     

Synergistic inhibition of human glioma cell line by temozolomide and PAMAM‐mediated miR‐21i

Temozolomide (TMZ) is a promising chemotherapeutic agent for treating glioblastomas. However, resistance develops quickly and with a high frequency. Efforts to overcome chemoresistance are, therefore, critically needed. In present study, a poly(amidoamine; PAMAM) dendrimer was used as a vector to deliver microRNA‐21 inhibitor (miR‐21i) into U87 cells and the chemosensitivity of the combination effect of miR‐21i and TMZ for glioma therapy was investigated. Flow cytometry analysis showed the uptake efficiency of microRNA‐21 inhibitor after complexation with PAMAM. Real‐time PCR and in situ hybridization indicated that, compared with TMZ or miR‐21i treated cells, cells simultaneously treated with miR‐21i and TMZ showed a remarkable decrease in the microRNA‐21 (miR‐21) level. The transfection of miR‐21i enhanced the chemosensitivity by significantly decreasing the IC50 value of TMZ to glioma cells. Knockdown of miR‐21 promoted the cells' apoptosis, and at the same time, inhibited cell invasion. In conclusion, the combination treatment of glioma cells with TMZ and miR‐21i could yield a synergistic effect in inhibition of human glioma cell line. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013     

United Nations General Assembly Resolution: International Decade for Action,Water for Life, 2005–2015

Abstract

Of the voluminous resolutions issued by United Nations General Assembly, the Millennium Declaration, adopted in 2000, is one of the most significant. It specifies eight development goals and sets the year 2015 as the target date for achieving such goals. Although water is not explicitly mentioned as one of those eight principal goals, it is specified as a subset under one of those goals. Three years later, the United Nations General Assembly paid special attention to water by issuing a separate resolution declaring the period 2005 to 2015 as the “International Decade for Action, Water for Life.” This article reviews and discusses the Resolution and analyzes its added value.