基于.net技术的自动化立体仓库管理与控制系统的研究与实现

研究并开发了基于.net的自动化立体仓库管理与控制系统。该系统运行于微软.net平台,采用ASP.NET技术和ADO.NET技术,实现了仓库所需的各项业务操作并具有界面友好、便于维护、信息共享性及扩展性好等许多优点,为实现仓储物资可视化提供了一个有价值的解决方案。     

Efficient and High-quality Recommendations via Momentum-incorporated Parallel Stochastic Gradient Descent-Based Learning

A recommender system (RS) relying on latent factor analysis usually adopts stochastic gradient descent (SGD) as its learning algorithm. However, owing to its serial mechanism, an SGD algorithm suffers from low efficiency and scalability when handling large-scale industrial problems. Aiming at addressing this issue, this study proposes a momentum-incorporated parallel stochastic gradient descent (MPSGD) algorithm, whose main idea is two-fold: a) implementing parallelization via a novel data-splitting strategy, and b) accelerating convergence rate by integrating momentum effects into its training process. With it, an MPSGD-based latent factor (MLF) model is achieved, which is capable of performing efficient and high-quality recommendations. Experimental results on four high-dimensional and sparse matrices generated by industrial RS indicate that owing to an MPSGD algorithm, an MLF model outperforms the existing state-of-the-art ones in both computational efficiency and scalability.      

一种多用途串口转换器的设计与实现

本文设计了一种多用途串口转换器,主要实现了以下功能:USB-RS232-TTL自动切换功能、RS232的收发自动切换功能及其热插拔功能、TTL的RXD-TXD收发自动切换功能及供电电源的正负极自动切换功能。该转换器实现了这三种常用接口的自动切换,为调试电路提供了方便。     

新型瓦斯检测系统硬件设计

针对矿用瓦斯检测系统中使用传感器的特点以及工作环境,加入温度、湿度数据采集环节,在软件算法方面提高测量准确度。设计中主要采用高共模抑制比的差分放大电路、开关电容滤波器提高信号源的精确度,同时抑制电源噪声以提高系统抗干扰性。     

Generalization of recommender systems: Collaborative filtering extended to groups of users and restricted to groups of items

In this paper we present a collaborative filtering method which opens up the possibilities of traditional collaborative filtering in two aspects: (1) it enables joint recommendations to groups of users and (2) it enables the recommendations to be restricted to items similar to a set of reference items. By way of example, a group of four friends could request joint recommendations of films similar to “Avatar” or “Titanic”. In the paper, using experiments, we show that the traditional approach of collaborative filtering does not satisfactorily resolve the new possibilities contemplated; we also provide a detailed formulation of the method proposed and an extensive set of experiments and comparative results which show the superiority of designed collaborative filtering compared to traditional collaborative filtering in: (a) number of recommendations obtained, (b) quality of the predictions, (c) quality of the recommendations. The experiments have been carried out on the databases Movielens and Netflix.     

Pellets for oral administration of low-molecular-weight heparin

Background: Oral absorption of low-molecular-weight heparin (LMWH) is limited by its molecular size and negative charge. It has been shown previously that orally administered polymeric nano- or microparticles containing encapsulated LMWH have led to gastrointestinal absorption of heparin in rabbits. Method: Based on these investigations, pellets containing two LMWHs, enoxaparin (MW 4500 Da) or bemiparin (MW 3600 Da), and Eudragit®RS30D (ERS), were prepared using extrusion/ spheronization technique. Uncoated or coated (ERS) pellets were evaluated in vitro and in vivo on rabbits. Results: Enoxaparin pellets showed fast in vitro release in phosphate buffer (pH 7.4) and prolonged in vivo drug absorption after a single oral dose of 600 anti-Xa IU/ kg of body weight, leading to relative bioavailabilities ranging from 9.7 ± 1.9% to 12.8 ± 2.7% and anti-Xa activity over the curative dose. Bemiparin included in matrix pellets of ERS and coated with ERS exhibited in vitro prolonged release up to 4 hours and in vivo anti-Xa activity below the therapeutic minimum value of 0.1 IU/mL. Conclusion: This study presents LMWH in a pellet dosage form, which compared to nano- or microparticles, may offer a more convenient and industrializable way of manufacture leading to an easier scale-up process.     

自动化立体仓库系统在飞机钣金模具管理中的应用

通过设计与规划自动化立体仓库管理系统,提出了以满足工段生产需求为目标的物流配送思想,以此思想为导向,优化模具管理流程,理顺内部客户关系,实现了飞机钣金零件模具的高效、准时配送。在飞机钣金模具管理中,与传统的模具仓库管理模式相比,自动化立体仓库系统节省了场地面积,降低了人工成本,提高了零件生产效率。     

Formulation of Insulin-Loaded Polymeric Nanoparticles Using Response Surface Methodology

The objective of this work was to formulate new oral insulin-loaded nanoparticules using the response surface methodology. The insulin nanoparticles were prepared by a water-in-oil-in-water emulsification and evaporation method. The polymers used for the encapsulation were blends of biodegradable poly-epsilon-caprolactone (PCL) and of positively-charged, nonbiodegradable polymer (Eudragis RS®). A central composite design has been built to investigate the effects of three controlled variables: ratio of polymers (PCL/RS ratio), volume, and pH of the aqueous solution of polyvinyl alcohol. The nanoparticles were characterized by measuring the amount of entrapped insulin, the particle size, the polydispersity of the obtained particles, the zeta potential, and the amount of insulin released after 7 hours. A second-order model was evaluated by multiple regression and was statistically tested for each of the studied controlled variable. The obtained polynomials proved efficient to localize an optimal operating area highlighted by the use of three-dimensional response surfaces and their corresponding isoresponse curves. An interesting formulation given by the models was selected, prepared, and evaluated. The corresponding quantity of entrapped insulin was 25 IU per 100 mg of polymer, and the particle size was 350 nm with a polydispersity of 0.21. The quantity of released insulin was 4.8 IU per 100 mg of polymer after 7 hours and the zeta potential was + 44 mV. All these collected values were in perfect accordance with values estimated by the models. Finally, the results suggested that PCL/RS 50/50 nanoparticles might represent a promising formulation for oral delivery of insulin.     

基于USB2.0接口的PCM数据采集器设计与实现

为满足X型飞机飞行试验的需求,设计了基于USB2.0接口的PCM数据采集器,该采集器实现了对机载环境下振动参数的采集、记录和实时监控功能,具备对100%及部分机载环境振动参数的PCM、RS422数据流记录功能,通过USB接口实现了上位机对100%PCM数据、可选RS422数据流的加载及实时监控功能。     

SF6密度继电器RS-485通信终端电阻匹配方法研究

SF6密度继电器能够实现对高压电器设备中SF6绝缘气体状态的实时在线监测,然而在工程实践中采常采用的RS-485组网方式存在着反射信号干扰的问题,需要在通信网络的末端SF6密度继电器中进行阻抗匹配,提出了一种软硬件结合的方法对终端电阻匹配进行控制,设计了电阻投切控制电路,并设计了相应的软件控制远传密度继电器内部终端电阻的投切,可以方便地实现RS-485通信网络的终端阻抗匹配,通过对信号波形进行分析,可以证明能够有效降地低信号反射所带来的不良影响。