中央亚洲活动带及邻区砂岩型铀矿床主要类型、铀成矿特征及在我国西北地区找矿方向的探讨

以产铀盆地所处大地构造位置、形成演化及铀矿化成因特征为基础,将中央亚洲活动带及邻区主要砂岩型铀矿床分为5种类型,分析了不同类型铀矿床的分布规律,对其产出构造地质背景和铀矿化特征进行了讨论,指出了我国西北地区盆地动力学的特征、主要找矿类型和含矿层位。     

空间下弦式液压滑模在小孤山水电站调压井的应用

文中论述了在张掖小孤山电站洞压井的竖井井筒部位采用空间下弦式液压滑模进行衬砌施工的过程,该技术的应用减少了钢材的消耗量,降低了爬升系统的运行难度,整体抗变形能力加强,保证了工程质量.     

燃煤含硫量对高参数机组锅炉选型的影响

针对燃煤特性(主要是含硫量)对锅炉参数选择可能带来的影响,以美国B&W公司对各种钢材的年腐蚀量试验数据为依据,对高参数机组所能适用的燃煤含硫量进行了分析,指出对国内电厂燃煤含硫量超过2%以上机组不适宜采用超(超)临界机组。     

Sensitivity analysis of nonlinear fractional order control systems with state delay

In this paper, we consider a class of nonlinear fractional order control system with delay in state variable. Existence and uniqueness of solution are shown by using method of steps. The sensitivity of the state and control with respect to the parameters of the system is shown. Finally, analytical results are substantiated by numerical examples.     

电机车运行定位系统的单片机控制

为解决焦化行业用电机车采用人工驾驶、定位精度差、劳动强度大的现状,提出了一种基于单片机AT89C51的电机车半自动化运行控制系统,为实现电机车的无人驾驶奠定了基础。介绍了AT89C51根据炉号识别系统、脉冲编码器及三灯对正传感器的位置反馈信号,确定电机车运行速度曲线的方法。变频器ACS800采用主/从控制方式,实现了两台电机以轮对车轮对铁轨无相对滑动为基准的同步运行,及负载在变频器之间的均匀分配。给出了该系统硬件构成框图及软件流程图。本系统结构简单,实现方便,控制精度高,对恶劣环境有较强的适应能力。     

Soluble Epoxide Hydrolase and Diabetes Complications

Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke. T2DM also increases the risks of depression and dementia for reasons that remain largely unclear. Perturbations in the cytochrome P450-soluble epoxide hydrolase (CYP-sEH) pathway have been implicated in each of these diabetes complications. Here we review evidence from the clinical and animal literature suggesting the involvement of the CYP-sEH pathway in T2DM complications across organ systems, and highlight possible mechanisms (e.g., inflammation, fibrosis, mitochondrial function, endoplasmic reticulum stress, the unfolded protein response and autophagy) that may be relevant to the therapeutic potential of the pathway. These mechanisms may be broadly relevant to understanding, preventing and treating microvascular complications affecting the brain and other organ systems in T2DM.     

Mitochondrial Dysfunction in Spinocerebellar Ataxia Type 3 Is Linked to VDAC1 Deubiquitination

Dysfunctional mitochondria are linked to several neurodegenerative diseases. Metabolic defects, a symptom which can result from dysfunctional mitochondria, are also present in spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, the most frequent, dominantly inherited neurodegenerative ataxia worldwide. Mitochondrial dysfunction has been reported for several neurodegenerative disorders and ataxin-3 is known to deubiquitinylate parkin, a key protein required for canonical mitophagy. In this study, we analyzed mitochondrial function and mitophagy in a patient-derived SCA3 cell model. Human fibroblast lines isolated from SCA3 patients were immortalized and characterized. SCA3 patient fibroblasts revealed circular, ring-shaped mitochondria and featured reduced OXPHOS complexes, ATP production and cell viability. We show that wildtype ataxin-3 deubiquitinates VDAC1 (voltage-dependent anion channel 1), a member of the mitochondrial permeability transition pore and a parkin substrate. In SCA3 patients, VDAC1 deubiquitination and parkin recruitment to the depolarized mitochondria is inhibited. Increased p62-linked mitophagy, autophagosome formation and autophagy is observed under disease conditions, which is in line with mitochondrial fission. SCA3 fibroblast lines demonstrated a mitochondrial phenotype and dysregulation of parkin-VDAC1-mediated mitophagy, thereby promoting mitochondrial quality control via alternative pathways.     

Generalized Approach towards Secretion-Based Protein Production via Neutralization of Secretion-Preventing Cationic Substrate Residues

Many heterologous proteins can be secreted by bacterial ATP-binding cassette (ABC) transporters, provided that they are fused with the C-terminal signal sequence, but some proteins are not secretable even though they carry the right signal sequence. The invention of a method to secrete these non-secretable proteins would be valuable both for understanding the secretory physiology of ABC transporters and for industrial applications. Herein, we postulate that cationic “supercharged” regions within the target substrate protein block the secretion by ABC transporters. We also suggest that the secretion of such substrate proteins can be rescued by neutralizing those cationic supercharged regions via structure-preserving point mutageneses. Surface-protruding, non-structural cationic amino acids within the cationic supercharged regions were replaced by anionic or neutral hydrophilic amino acids, reducing the cationic charge density. The examples of rescued secretions we provide include the spike protein of SARS-CoV-2, glutathione-S-transferase, streptavidin, lipase, tyrosinase, cutinase, growth factors, etc. In summary, our study provides a method to predict the secretability and a tool to rescue the secretion by correcting the secretion-blocking regions, making a significant step in understanding the physiological properties of ABC transporter-dependent protein secretion and laying the foundation for the development of a secretion-based protein-producing platform.     

Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis

Systemic sclerosis (SSc) is characterized by excessive collagen deposition in the skin and internal organs. Activated fibroblasts are the key effector cells for the overproduction of type I collagen, which comprises the α1(I) and α2(I) chains encoded by COL1A1 and COL1A2, respectively. In this study, we examined the expression patterns of α1(I) and α2(I) collagen in SSc fibroblasts, as well as their co-regulation with each other. The relative expression ratio of COL1A1 to COL1A2 in SSc fibroblasts was significantly higher than that in control fibroblasts. The same result was observed for type I collagen protein levels, indicating that α2(I) collagen is more elevated than α2(I) collagen. Inhibition or overexpression of α1(I) collagen in control fibroblasts affected the α2(I) collagen levels, suggesting that α1(I) collagen might act as an upstream regulator of α2(I) collagen. The local injection of COL1A1 small interfering RNA in a bleomycin-induced SSc mouse model was found to attenuate skin fibrosis. Overall, our data indicate that α2(I) collagen is a potent regulator of type I collagen in SSc; further investigations of the overall regulatory mechanisms of type I collagen may help understand the aberrant collagen metabolism in SSc.     

非线性耗散型Schrodinger方程的惯性分形集

证明了非线性耗散型Schrodinger方程初边值问题的解半群S(t)的Lipschitz连续性和挤压性,得到了惯性分形集的存在性。