Combined Treatment with Cryptocaryone and Ultraviolet C Promotes Antiproliferation and Apoptosis of Oral Cancer Cells

Cryptocaryone (CPC) was previously reported as preferential for killing natural products in oral cancer cells. However, its radiosensitizing potential combined with ultraviolet C (UVC) cell killing of oral cancer cells remains unclear. This study evaluates the combined anti-proliferation effect and clarifies the mechanism of combined UVC/CPC effects on oral cancer cells. UVC/CPC shows higher anti-proliferation than individual and control treatments in a low cytotoxic environment on normal oral cells. Mechanistically, combined UVC/CPC generates high levels of reactive oxygen species and induces mitochondrial dysfunction by generating mitochondrial superoxide, increasing mitochondrial mass and causing the potential destruction of the mitochondrial membrane compared to individual treatments. Moreover, combined UVC/CPC causes higher G2/M arrest and triggers apoptosis, with greater evidence of cell cycle disturbance, annexin V, pancaspase, caspases 3/7 expression or activity in oral cancer cells than individual treatments. Western blotting further indicates that UVC/CPC induces overexpression for cleaved types of poly (ADP-ribose) polymerase and caspase 3 more than individual treatments. Additionally, UVC/CPC highly induces γH2AX and 8-hydroxy-2’-deoxyguanosine adducts as DNA damage in oral cancer cells. Taken together, CPC shows a radiosensitizing anti-proliferation effect on UVC irradiated oral cancer cells with combined effects through oxidative stress, apoptosis and DNA damage.     

锚索锚杆挂网喷碹联合支护在煤巷中的应用

鹤岗矿业集团公司兴安煤矿在岩巷穿煤中采用锚索锚杆挂网喷碹联合支护取得成功,取得了较好的技术经济效果。     

无旁通烟囱燃气_蒸汽联合循环机组的运行维护和停运

论述了无旁通烟囱燃气－蒸汽联合循环机组运行维护和停运的特点,探讨了它与火力发电厂和有旁通烟囱联合循环的不同之处,总结了机组运行维护和停动的经验,可供运行人员和设计人员参考。     

Optimum performance of a heat engine‐driven combined vapour compression–absorption–ejector heat pump

Optimum performance of an endoreversible heat engine‐driven heat pump cycle, based on a combination of an absorption cycle with a vapour and ejector compression cycles is investigated. This combination increases the performance of the conventional ejector and absorption cycles and provides high performance for heating. The analysis show that the combined heat pump cycle has a significant increase in system performance over the heat engine‐driven vapour compression or absorption heat pump cycle and heat engine‐driven combined vapour compression and absorption heat pump cycle. Copyright © 2000 John Wiley & Sons, Ltd.     

一种全新型太阳能供热与制冷联合循环复合系统──Ⅰ.系统构造思想

提出一种利用太阳能作为驱动热源的固体吸附式制冷与供热联合循环方法,描述了太阳能制冷与供热联合循环的工作原理,并对循环装置内各子系统部件的热力循环过程和能量转化过程作了理论分析与计算说明。采用该联合循环装置,可实现用同一集热器白天加热的热水供夜间使用,夜间制的冰供白天使用的目的     

Transport of pollutant in shallow flows: A space–time CE/SE scheme

This paper focuses on implementation of space–time CE/SE scheme for computing the transport of a passive pollutant by a flow. The flow model comprises of the Saint-Venant system of shallow water equations and the pollutant propagation is described by a transport equation. The one-dimensional and two-dimensional flow equations are numerically investigated using the CE/SE scheme. A number of test problems are presented to check the accuracy and efficiency of the proposed scheme. The results of CE/SE scheme are compared with the central scheme. Both the schemes are found to be in close agreement. However, our proposed CE/SE scheme accurately captures shocks and discontinuous profiles.     

MAC finite difference scheme for Stokes equations with damping on non-uniform grids

In this paper, we consider the numerical methods for stationary Stokes equations with damping. The mark and cell(MAC) method has been applied to discretize the problem on non-uniform grids. We establish the LBB condition and the stability for the MAC scheme. Then we obtain the second order super-convergence in L2 norm for both velocity and pressure on non-uniform grids. We also obtain the second order convergence for some terms of H1 norm of the velocity, and the other terms of H1 norm are second order convergence on uniform grids. Numerical experiments using the MAC scheme show agreement of the numerical results with theoretical analysis.     

某型飞机刹车系统内部串油分析

阐述某型飞机刹车系统组成和原理,介绍该飞机在一次滑行过程中出现的故障现象,对该故障进行原理分析,通过机上试验将故障原因定位为刹车系统内部串油,并分析该故障发生时刹车系统内部串油是由转换活门引起的,即在松刹时转换活门内部活塞两端压差导致活塞密封失效引起内部串油,针对此原因给出两条改进建议。     

An Extended Finite Variable Difference Method with Application to QUICK Scheme

A Finite Variable Difference Method (FVDM) proposed previously by the author for locally exact numerical schemes is extended so as to be applicable to polynomial expansion schemes. This extended FVDM is applied to the QUICK scheme.

The optimum differencing points are analytically derived in terms of mesh Reynolds numbers so that the variance of the numerical solution is minimized under the condition that roots of the resulting characteristic equation are nonnegative to insure the numerical stability. This optimized scheme coincides with the original QUICK scheme at Rm=8/3, which is the critical value of its stability, and complements a stable scheme for Rm greater than 8/3. This optimization improves the numerical solution for the steady and unsteady convection-diffusion equations without numerical oscillations.

In the same manner as the previous result for the locally exact numerical schemes, it has been made clear based on the extended FVDM that optimum differencing points from the view point of numerical stability and accuracy exist for the polynomial expansion schemes.