原发性高血压病靶器官损害的预测仿真研究

研究原发性高血压病靶器官损害准确预测问题,由于原发性高血压病靶器官损害的影响因子之间存在着高度冗余和非线性,导致传统方法预测准确率低,为提高预测精度,构建了一种改进的基因表达式编程算法的原发性高血压病靶器官损害预测模型,首先设计了适合靶器官损害预测的适应度函数,然后为克服早熟现象提出了以平均适应度形式自适应的改变重组算子概率和变异算子概率,通过数据训练得到靶器官损害的2年预测模型。采用对山东中医药大学第二附属医院原发性高血压病历史数据进行验证性仿真,结果表明,方法的预测精度更高,在原发性高血压病靶器官损害的预测中有着广泛的应用前景。     

表面n沟CCD的电离辐射损伤

本文报道了150光敏元表面n沟CCD(电荷耦合器件)在不同能量电子和γ射线辐照后的电离辐射效应。试验结果表明,转移失效率在≤10Gy时已明显增大。但大多数器件在累积剂量≤50Gy时,通过调整“胖零”注入仍可工作。在高剂量辐照期间,不同栅偏压器件的转移效率退化存在较大差异。应用高频和准静态C-V技术分析了参数退化的原因。     

Surface characterization of 6H-SiC (0001) substrates in indentation and abrasive machining

Surface characterization of 6H-SiC (0001) substrates in indentation and abrasive machining was carried out to investigate microfracture, residual damage, and surface roughness associated with material removal and surface generation. Brittle versus plastic deformation was studied using Vickers indention and nano-indentation. To characterize the abrasive machining response, the 6H-SiC (0001) substrates were ground using diamond wheels with grit sizes of 25, 15 and 7 μm, and then polished with diamond suspensions of 3 and 0.05 μm. It is found that in indentation, there was a scale effect for brittle versus plastic deformation in 6H-SiC substrates. Also, in grinding, the scales of fracture and surface roughness of the substrates decreased with a decrease in diamond grit size. However, in polishing, a reduction in grit size of diamond suspensions gave no significant improvement in surface roughness. Furthermore, the results showed that fracture-free 6H-SiC (0001) surfaces were generated in polishing with the existence of the residual crystal defects, which were associated with the origin of defects in single crystal growth.     

用局部法评定焊接接头的疲劳性能

采用16Mn钢非承载十字焊接接头疲劳试验结果对使用Dang Van准则的疲劳评定局部方法进行了研究。结果表明，有限元分析中应力集中区单元尺寸对局部参量计算有明显影响，为获得比较合理的预测结果需对焊趾应力集中区所划分的单元尺寸限定，当接头焊趾半径在0．15-0．8mm变化时应选择最小单元尺寸0．32-0．62mm计算局部参量；在此基础上Dang Van准则可以对焊态接头做出合理的评定，但Dang Van建议的卢值偏安全。此外，通过计算发现焊趾半径只影响局部很小区域(约0．5mm内)的应力集中分布，在某一深度(约0．5mm)后存在稳定的应力集中，因而建议采用距应力集中区最大应力处某一深度的应力参数计算Dang Van局部参量可能更为合理，这将减小局部参数对焊趾半径及单元尺寸的依赖性。     

矿岩粉碎全过程能耗-粒度关系的连续损伤理论研究SCIEI

本文从连续损伤理论的观点出发,将矿岩粉碎过程描述为在外部荷载作用下矿岩颗粒内部微缺陷(损伤)演化和繁衍的过程。导出了粉碎能耗与产品粒度分布的理论表达式。该式包含了所有传统的理论,同时较传统的能量分配观点前进了一步。     

OsMre11 Is Required for Mitosis during Rice Growth and Development

Meiotic recombination 11 (Mre11) is a relatively conserved nuclease in various species. Mre11 plays important roles in meiosis and DNA damage repair in yeast, humans and Arabidopsis, but little research has been done on mitotic DNA replication and repair in rice. Here, it was found that Mre11 was an extensively expressed gene among the various tissues and organs of rice, and loss-of-function of Mre11 resulted in severe defects of vegetative and reproductive growth, including dwarf plants, abnormally developed male and female gametes, and completely abortive seeds. The decreased number of cells in the apical meristem and the appearance of chromosomal fragments and bridges during the mitotic cell cycle in rice mre11 mutant roots revealed an essential role of OsMre11. Further research showed that DNA replication was suppressed, and a large number of DNA strand breaks occurred during the mitotic cell cycle of rice mre11 mutants. The expression of OsMre11 was up-regulated with the treatment of hydroxyurea and methyl methanesulfonate. Moreover, OsMre11 could form a complex with OsRad50 and OsNbs1, and they might function together in non-homologous end joining and homologous recombination repair pathways. These results indicated that OsMre11 plays vital roles in DNA replication and damage repair of the mitotic cell cycle, which ensure the development and fertility of rice by maintaining genome stability.     

Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

Dysregulation of retinal function in the early stages of light-induced retinal degeneration involves pannexins and connexins. These two types of proteins may contribute to channels that release ATP, leading to activation of the inflammasome pathway, spread of inflammation and retinal dysfunction. However, the effect of pannexin channel block alone or block of both pannexin channels and connexin hemichannels in parallel on retinal activity in vivo is unknown. In this study, the pannexin channel blocker probenecid and the connexin hemichannel blocker tonabersat were used in the light-damaged rat retina. Retinal function was evaluated using electroretinography (ERG), retinal structure was analyzed using optical coherence tomography (OCT) imaging and the tissue response to light-induced injury was assessed immunohistochemically with antibodies against glial fibrillary acidic protein (GFAP), Ionized calcium binding adaptor molecule 1 (Iba-1) and Connexin43 (Cx43). Probenecid did not further enhance the therapeutic effect of connexin hemichannel block in this model, but on its own improved activity of certain inner retina neurons. The therapeutic benefit of blocking connexin hemichannels was further evaluated by comparing these data against results from our previously published studies that also used the light-damaged rat retina model. The analysis showed that treatment with tonabersat alone was better than probenecid alone at restoring retinal function in the light-damaged retina model. The results assist in the interpretation of the differential action of connexin hemichannel and pannexin channel therapeutics for potential treatment of retinal diseases.     

A damage model for assessing pipeline safety in corrosion environments

Considering such practical pipeline service conditions in the petroleum transportation field as corrosion from harmful media (H₂S, CO₂ etc.) and load from the pressure of flowing petroleum as key factors, the degradation of the mechanical properties of pipeline steels and the corresponding variations in stress states are studied. A damage variable is introduced to reflect the degradation in the mechanical properties of the pipeline due to corrosion. A diluted solution approach is proposed to model the corrosion process of harmful media within the pipeline and the distribution of the damage variable along the radial direction of the pipeline is derived. An approach to the safety evaluation of damaged pipeline is proposed by comparing the instant properties of pipeline steels with servicing conditions.     

长期高温服役的12%Cr耐热合金钢性能退化与恢复

X2 0CrMoV12 1耐热合金钢广泛应用于热电厂主蒸汽管线等主要部件。经长期高温负荷运行后 ,材料性能明显退化。观察显微组织发现 ,材料性能下降是和晶界碳化物的粗化密切相关的。文章着重研究了损伤材料重新热处理后的性能和组织结构的变化 ,初步探讨了材料长期服役后通过热处理恢复其原始性能的可能性     

金属板材成形中拉深损伤模拟的两种求解方法

讨论用数值模拟预测板材成形中发生拉深损伤破坏的两种不同的求解方法。第一种是采用完全耦合的弹塑性破坯模型的动力显式数值方法。基于状态参量的不可逆热力学过程 ,完全耦合的本构方程考虑各向同性强化和拉深。这些已引入有限元软件ABAQUS/E用于对金属成形的模拟。在数值技术方面 ,隐式积分方法被用来对本构方程的局部时间积分 ,动力显式技术用于求解总体平衡方程。第二种方案是采用简化的损伤模型的方法 ,被称为逆法 (InveseApprch)。I.A被限定在考虑各向同性强化和损伤的塑性全量理论基础上的简单的本构关系。做比例加载和临界损伤达到以后的损伤饱和假定 ,可以得到损伤演化方程的封闭解。这两种损伤模型在编程中的实施采用两种方式 :计算中考虑或不考虑损伤作用 ,也就是耦合的或非耦合的计算。文中给出一些算例来说明每种损伤模型的优点