基于双规准反应谱的抗震设计谱

以千余条水平分量地震动记录为数据基础,考虑场地条件,距离和震级的影响,对地震动的加速度规准反应谱和双规准反应谱进行了研究.规准反应谱明显受到场地条件,距离和震级的影响,但场地、距离和震级影响下的平均双规准谱之间却表现出良好的一致性,基于此建议了统一的双规准设计谱模型.考虑阻尼比的影响和与现行规范设计谱的衔接,建议了可供工程设计参考使用的抗震设计谱,并与现行规范设计谱进行了比较.     

Analysis of asphalt pavement structural response from an accelerated loading test

This study was to compare theoretical calculation and practical measurement structure response of asphalt pavement. Analysis of the pavement layer moduli was determined from a Back-calculation of Falling Weight Deflectometer (FWD) data and the measured stiffness moduli of asphalt layer cores. The pavement response was calculated using a theoretical model and the measured strain response at the bottom different layers. Layered elastic theory was used to back-calculate the layer moduli and three different theory models were used to forward calculate the strain and deflection. The models were: Layered Elastic Theory (LET), the Method of Equivalent Thicknesses (MET) with linear elastic and the Finite Element Method (FEM) where asphalt layer may be viscoelastic. The results showed that the calculation structure response from FEM was consistent with measured results.     

嫦娥一号卫星X射线谱仪的性能模拟

本文主要讲述了嫦娥一号卫星(CE-1)X射线谱仪(LOXIA)的性能模拟.包括,探测效率的模拟;探测器能谱响应的模拟;角度响应的模拟三个方面,并对模拟结果进行分析,为谱仪的研制提供了参考.     

隧道洞口上方危岩崩塌块石运动规律及其对隧道的危害

为揭示危岩崩塌块石的运动规律及其对下方隧道洞口的危害,以都香高速昭通段乐红隧道洞口高陡边坡危岩区崩塌体为研究对象,运用理论计算与Rockfall数值计算2种形式对危岩区崩塌体失稳后块石的运动特征进行预测,运用Abaqus有限元软件模拟不同初速度、不同冲击落点下块石冲击隧道结构的动力响应,揭示不同因素对块石冲击隧道结构的...     

钒自给能探测器延迟信号数字处理算法与实验研究

钒自给能探测器（VSPND）输出电流信号的慢响应特性严重影响反应堆内中子通量的实时测量,不利于反应堆的控制和安全管理。采用反函数计算或各种补偿方法改进其响应特性,有利于VSPND的使用。本文研究了前向差分变换法、后向差分变换法、阶跃响应不变法及双线性变换法等4种数字处理算法,提出了两次处理的方法,有效缩短了VSPND输出信号的响应时间,时间常数由325.47 s减少到7 s以内,其中阶跃响应不变法算法的时间常数最小为5.2 s。设计了数字实验系统,验证了算法的正确性,为该探测器用于反应堆内中子通量测量的快速响应提供了可行性。     

影响窗玻璃γ辐射响应的电子自旋共振波谱研究

为更好应用于人员剂量估算和事故等级测定,探索了影响窗玻璃电子自旋共振波谱剂量学性质的因素。实验将窗玻璃处理成不同粒度大小,分别研究研磨处理对本底信号和辐射信号的影响。给予窗玻璃样本不同照射剂量,存储在不同条件下,观察温度、光线、时间等对电子自旋共振波谱(ESR)信号的影响。对比了来源不同的窗玻璃剂量响应曲线和最小检测剂量。结果表明,前期样本处理对窗玻璃辐射信号并无明显影响,但会产生机械信号;温度越高,窗玻璃辐射信号越不稳定。高温加热(≥200 ℃,≥5 min)可使照射后的ESR信号衰退至本底信号;透明袋-灯光和黑袋存储条件下的样本结果大致相同:11小时信号强度衰减9%左右,150小时衰减约18%。透明袋-阳光样品:11小时信号衰减了17%,150小时衰减38%。三种存储条件下的样本在150小时左右之后均达到稳定状态;窗玻璃样品在g=2.005 7处ESR信号与吸收剂量线性相关,线性相关性系数因来源于不同生产厂家而有差异。窗玻璃最小检测剂量是4~5 Gy。因此,在窗玻璃作为剂量计的实践中,注意以上问题,建立合理的剂量评估操作程序,可以估算出更为准确的结果。     

Cell-Based Chemical Safety Assessment and Therapeutic Discovery Using Array-Based Sensors

Synthetic chemicals are widely used in food, agriculture, and medicine, making chemical safety assessments necessary for environmental exposure. In addition, the rapid determination of chemical drug efficacy and safety is a key step in therapeutic discoveries. Cell-based screening methods are non-invasive as compared with animal studies. Cellular phenotypic changes can also provide more sensitive indicators of chemical effects than conventional cell viability. Array-based cell sensors can be engineered to maximize sensitivity to changes in cell phenotypes, lowering the threshold for detecting cellular responses under external stimuli. Overall, array-based sensing can provide a robust strategy for both cell-based chemical risk assessments and therapeutics discovery.     

Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response

Cyclin-dependent kinases (CDKs) are pivotal mediators and effectors of the DNA damage response (DDR) that regulate both the pathway components and proteins involved in repair processes. Synthetic lethality (SL) describes a situation in which two genes are linked in such a way that the lack of functioning of just one maintains cell viability, while depletion of both triggers cell death. Synthetic lethal interactions involving CDKs are now emerging, and this can be used to selectively target tumor cells with DNA repair defects. In this review, SL interactions of CDKs with protooncogene products MYC, poly (ADP-ribose) polymerase (PARP-1), and cellular tumor antigen p53 (TP53) are discussed. The individual roles of each of the SL partners in DDR are described.     

Targeting the DNA Damage Response to Increase Anthracycline-Based Chemotherapy Cytotoxicity in T-Cell Lymphoma

Mature T-cell lymphomas (MTCLs) represent a heterogeneous group of aggressive non-Hodgkin lymphomas comprising different entities. Anthracycline-based regimens are considered the standard of care in the front-line treatment. However, responses to these approaches have been neither adequate nor durable, and new treatment strategies are urgently needed to improve survival. Genomic instability is a common feature of cancer cells and can be caused by aberrations in the DNA damage response (DDR) and DNA repair mechanisms. Consistently, molecules involved in DDR are being targeted to successfully sensitize cancer cells to chemotherapy. Recent studies showed that some hematological malignancies display constitutive DNA damage and intrinsic DDR activation, but these features have not been investigated yet in MTCLs. In this study, we employed a panel of malignant T cell lines, and we report for the first time the characterization of intrinsic DNA damage and basal DDR activation in preclinical models in T-cell lymphoma. Moreover, we report the efficacy of targeting the apical kinase ATM using the inhibitor AZD0156, in combination with standard chemotherapy to promote apoptotic cell death. These findings suggest that DDR is an attractive pathway to be pharmacologically targeted when developing novel therapies and improving MTCL patients’ outcomes.