Cu48Zr4l7块体非晶合金的晶化行为及热力学性能研究

采用水冷铜模吸铸工艺制备出了片状Cu48Zr45Al7,块体非晶合金.X射线衍射(XRD)表明,样品为完全非晶.利用差示扫描量热分析仪(DSC)在不同的升温速率下连续加热测得该片状非晶合金的热稳定性参数值,均随着升温速率的增加而增加,表明其玻璃转变和晶化行为均存在显著的动力学效应.运用Kissinger法计算出其玻璃转变温度激活能(Eg)、晶化温度激活能(Ex)和峰值温度激活能(Ep)分别为424.7 kJ·mol-1,326.3 kJ·mol-1和297.1kJ·mol-1.从热力学模型角度出发,对该合金的非晶形成能力进行了分析,计算出其混合焓ΔHchem=-25.55 kJ.mol-1和归一化错配熵So/kB=0.78.结果表明,该块体非晶合金具有较强的非晶形成能力(AFA)NI良好的热稳定性.     

特高压直流送端系统的运行约束及新能源消纳挑战研究

针对特高压直流工程投运后电网特性的变化,分析了电力系统安全、经济运行面临的挑战及可采取的对策。首先在简要介绍直流系统故障的基础上,分别针对有功回退引起的暂态功角稳定问题与无功冗余造成的暂态过电压问题进行了理论分析,并根据陕西电网仿真计算结果进一步说明直流投运后对运行灵活性的制约。然后分析了运行灵活性下降对新能源消纳造成的影响,讨论了提高新能源消纳能力的对策。最后对所讨论问题进行归纳总结,并提出了未来工作与研究的展望。     

考虑客户画像和能量枢纽的配电网多目标抢修重构模型

随着大规模风电以及能量枢纽接入配电网,配电网故障后抢修重构面临新挑战,提出一种考虑客户画像和能量枢纽的配电网多目标多故障抢修重构模型。通过对配电网用电客户多因素精准画像,确定权重,建立兼顾客户画像和能量枢纽的配电网多目标抢修重构模型,提出一种改进NSGA-II算法以适应对模型求解,从而获得Pareto解集,并利用模糊最大满意度进行决策。算例仿真表明所提模型正确有效,与传统模型相比更加精细而客观。     

计及多能需求的综合能源服务商优化运行策略研究

随着分布式发电技术的不断成熟及发展,未来综合能源服务将是整合不同类型分布式发电并满足用户不同用能需求的有效途径。提出了一种含有多种分布式发电资源同时考虑多用能需求的综合能源服务商优化运行策略模型。首先建立了含有风电、光伏、燃气轮机、电储能、电热泵、辅助锅炉等分布式资源及电、热用能需求的园区综合能源系统优化调度模型;其次计算优化运行后的能源利用效率;最后,分析对比了不同季节、实时电价及天然气价格变化对综合能源服务商运行策略及盈利的影响。仿真结果验证了模型的有效性,其中综合能源服务商的收益对天然气的价格变化更为敏感。     

基于改进深度强化学习的智能微电网群控制优化方法

针对微电网群控制的经济效益、负荷波动以及碳排放问题,提出一种基于改进深度强化学习的智能微电网群运行优化方法。首先,计及分布式电源、电动汽车及负荷特性,提出微电网的系统模型。然后,针对微电网群的运行特点,提出4个系统优化目标和5个约束条件,并且引入分时电价机制调控负荷运行。最后,利用改进深度强化学习算法对微电网群进行优化,合理调控多种能源协同出力,调整负荷状态,实现电网经济运行。仿真结果表明了所提方法的有效性,与其他方法相比,其收益较高且碳排放量较小,可实现系统的经济环保运行。     

Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy

With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10⁻⁶). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets.     

Operational optimization of a building-level integrated energy system considering additional potential benefits of energy storage

As a key component of an integrated energy system (IES), energy storage can effectively alleviate the problem of the times between energy production and consumption. Exploiting the benefits of energy storage can improve the competitiveness of multi-energy systems. This paper proposes a method for day-ahead operation optimization of a building-level integrated energy system (BIES) considering additional potential benefits of energy storage. Based on the characteristics of peak-shaving and valley-filling of energy storage, and further consideration of the changes in the system’s load and real-time electricity price, a model of additional potential benefits of energy storage is developed. Aiming at the lowest total operating cost, a bi-level optimal operational model for day-ahead operation of BIES is developed. A case analysis of different dispatch strategies verifies that the addition of the proposed battery scheduling strategy improves economic operation. The results demonstrate that the model can exploit energy storage’s potential, further optimize the power output of BIES and reduce the economic cost.     

Accurate Receptor-Ligand Binding Free Energies from Fast QM Conformational Chemical Space Sampling

Small molecule receptor-binding is dominated by weak, non-covalent interactions such as van-der-Waals hydrogen bonding or electrostatics. Calculating these non-covalent ligand-receptor interactions is a challenge to computational means in terms of accuracy and efficacy since the ligand may bind in a number of thermally accessible conformations. The conformational rotamer ensemble sampling tool (CREST) uses an iterative scheme to efficiently sample the conformational space and calculates energies using the semi-empirical ‘Geometry, Frequency, Noncovalent, eXtended Tight Binding’ (GFN2-xTB) method. This combined approach is applied to blind predictions of the modes and free energies of binding for a set of 10 drug molecule ligands to the cucurbit[n]urils CB[8] receptor from the recent ‘Statistical Assessment of the Modeling of Proteins and Ligands’ (SAMPL) challenge including morphine, hydromorphine, cocaine, fentanyl, and ketamine. For each system, the conformational space was sufficiently sampled for the free ligand and the ligand-receptor complexes using the quantum chemical Hamiltonian. A multitude of structures makes up the final conformer-rotamer ensemble, for which then free energies of binding are calculated. For those large and complex molecules, the results are in good agreement with experimental values with a mean error of 3 kcal/mol. The GFN2-xTB energies of binding are validated by advanced density functional theory calculations and found to be in good agreement. The efficacy of the automated QM sampling workflow allows the extension towards other complex molecular interaction scenarios.     

Optimization algorithm for ultra-sparse arrays in regional energy focusing

The setting of ultra-sparse arrays is one of key factors for the performance of regional energy focusing.This paper focuses on one of its typical applications:Precision Electronic Warfare by UAV,and proposes an optimization algorithm for ultra-sparse arrays to maximize the performance of regional energy focusing.First,we establish the joint optimization model of the interference waveform and the positions of elements.Second,particle swarm optimization (PSO) is adopted to iterate the positions of elements.Then,the target value of the subproblem is solved for the fitness criterion,as the current array is known in each step of the iteration.Finally,we get the optimal solution of the interference waveform and the ultra-sparse array by this method.Numerical results indicate that the algorithm can optimize the array effectively,and improve the indicators of regional energy focusing obviously.Whether the localization errors of elements exist or not,the algorithm provides a better performance than existing algorithms which only design the interference waveform.     

NDN数据提供者移动支持策略能耗建模与分析

基于数据提供者的移动节点在网络中的不同位置及不同移动速度,结合命名数据网络（NDN）请求者驱动的数据传输模式,提出了3类NDN移动支持策略的网络能耗解析表达式,为NDN移动网络的研究提供了形式化的建模方法.对这3类移动支持策略在不同场景下能耗的分析与比较结果表明,数据流行度分布、移动节点所处位置及移动速度对策略的能耗影响不尽相同,为后续探求最优能效的移动支持策略提供了理论参考.