一阶电路的四要素公式

给出了直流激励下的一阶电路的四要素公式,将经典分析的起点延伸到0_,使经典电路分析与现代电路分析的起点一致,统一了动态分析理论。     

使用网络分析仪测量外部品质因子

外部品质因子是设计谐振滤波器的重要参数,测量出外部品质因子对于获得所需要的滤波特征至关重要。本文描述了使用网络分析仪来测量外部品质因子的方法。文中讨论了单端口,双端口情况下如何测量外部品质因子,并推导了相关的测量公式。     

中国纺织业技术选择的宏观透视

在中国二元经济结构的背景之下,从理论上探讨了纺织业优化要素配置的技术选择路径,通过对1985—2005年中国纺织业要素产出效率的实证分析,考察了．人均资本产出的演变轨迹,并从优化要素配置的角度提出了中国纺织业未来产业结构调整和技术进步的政策建议。     

高校创新能力对创新人才培养质量的影响探究——基于30个区域创新指数

基于30个地区高校创新能力和人才创新指数,运用双变量相关性分析法,明确了高校创新能力对人才创新指数的25个关键影响因素。通过对25个关键影响因素的因子分析,提取了3个共性因子,分别为f₁研发资源、f₂创新平台建设、f₃创新主体。采用多元回归法,探究3个共性因子对人才创新指数的显著性影响。研究发现,地区高校的研发资源是重要因素,一定程度上影响着创新人才培养质量。基于此,提出了三条建议：重点优化地区高校研发资源;完善高校创新平台;不断提高创新主体的创新思维与创新能力。研究成果为高校提高科技创新型人才的培养质量提供一定理论指导。     

The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis

The functionally important NF-κB1 promoter polymorphism (−94ins/delATTG) significantly shapes inflammation and impacts the outcome of sepsis. However, exploratory studies elucidating the molecular link of this genotype-dependent pattern are lacking. Accordingly, we analyzed lipopolysaccharide-stimulated peripheral blood mononuclear cells from both healthy volunteers (n = 20) and septic patients (n = 10). All individuals were genotyped for the −94ins/delATTG NF-κB1 promoter polymorphism. We found a diminished nuclear activity of the NF-κB subunit p50 in ID/DD genotypes after 48 h of lipopolysaccharide stimulation compared to II genotypes (p = 0.025). This was associated with higher TNF-α (p = 0.005) and interleukin 6 concentrations (p = 0.014) and an increased production of mitochondrial radical oxygen species in ID/DD genotypes (p = 0.001). Although ID/DD genotypes showed enhanced activation of mitochondrial biogenesis, they still had a significantly diminished cellular ATP content (p = 0.046) and lower mtDNA copy numbers (p = 0.010) compared to II genotypes. Strikingly, these findings were mirrored in peripheral blood mononuclear cells taken from septic patients. Our results emphasize the crucial aspect of considering NF-κB subunits in sepsis. We showed here that the deletion allele of the NF-κB1 (−94ins/delATTG) polymorphism was associated with the lower nuclear activity of subunit p50, which, in turn, was associated with aggravated inflammation and mitochondrial dysfunction.     

The Regenerative Effects of c-Met Agonistic Antibodies in Vocal Fold Atrophy

Background: Atrophy of the vocal folds and the accompanying glottic insufficiency affect the quality of life. Although growth factors have been used to treat muscle atrophy, their effectiveness is limited by their short half-life. Methods: In total, 15 rabbits and 24 rats were used for the study. The right recurrent laryngeal nerves of all animals were transected. One month following nerve transection, PBS (PBS group), rHGF (HGF group), or a c-Met agonistic antibody (c-Met group) was injected into the paralyzed vocal folds. The larynges of the rabbits were harvested from each group for histologic examination and subjected to PCR analysis. Results: Cross-sectional areas (CSAs) of thyroarytenoid muscles were evaluated. The c-Met group had increased CSAs compared to the PBS and HGF groups, but there were no significant differences compared to normal controls. The expression levels of myogenesis-related genes were evaluated three weeks after the injection. The expression levels of myosin heavy chain IIa were significantly increased in the PBS group, while the expression levels of MyoD were increased in the c-Met group. Conclusions: The c-Met agonistic antibody showed promise for promoting muscle regeneration in a vocal fold palsy model.     

四川盆地下二叠统,上三叠统水动力场与天然气保存

下二叠统和上三叠统储集层是四川盆地油气主力产层。在对其水动力场控制因素分析研究的基础上，对实测地层压力资料进行数据处理，分别建立了Ｐ１和Ｔ３地层压力预测模型。地层埋深，孔隙度，构造抬升率和褶皱强度等为现今水动力场的主要控制因素，其中地层埋深对地层压力的影响最大。     

四川盆地老气田二次开发优化技术及应用

经过近60年的开发,四川盆地的许多老气田已进入低压、低产的开发中后期,部分气田虽然已濒临废弃,但其中仍尚存较多剩余天然气资源未采出。通过梳理分析,认为具备二次开发条件的气田多存在地层水活跃形成水封难以解封、低渗透储量难动用等问题。为此,从老气田二次开发的定义出发,全面阐述了其技术路线及优选条件:(1)在建立缝洞系统多储渗体模式的基础上,采用压力重整曲线进行地质模型正演、生产动态反演特征曲线诊断,提出了复杂岩溶缝洞系统多储渗体识别及定量描述方法,结合U型管气水赋存新模式,形成了强水侵多缝洞系统天然气储量计算新技术;(2)建立孔、洞、缝三重介质数值模型,形成强水侵底水缝洞气藏"水平井排水+直井采气"排采井网模拟及效果评价新技术;(3)依托精细气藏描述形成的配套集成技术,重构气藏地质模型,分类评价气藏低渗透储量,结合井网优化、水平井地质导向、分段酸化压裂等工艺技术,进一步提高有效动用率;(4)建立多节点、多环节输气管网模型,形成区域性管网整体模拟优化及预测技术。实施效果表明,该二次开发技术在老气田产能建设、提高老气田采收率、延缓老气田产量递减、稳定老气田产量等方面均具有明显成效。     

NGF Modulates Cholesterol Metabolism and Stimulates ApoE Secretion in Glial Cells Conferring Neuroprotection against Oxidative Stress

Cholesterol plays a crucial role in the brain, where its metabolism is particularly regulated by astrocytic activity. Indeed, adult neurons suppress their own cholesterol biosynthesis and import this sterol through ApoE-rich particles secreted from astrocytes. Recent evidence suggests that nerve growth factor (NGF) may exert neurotrophic activity by influencing cell metabolism. Nevertheless, the effect of NGF on glial cholesterol homeostasis has still not been elucidated. Thus, the aim of this project is to assess whether NGF could influence cholesterol metabolism in glial cells. To reach this objective, the U373 astrocyte-derived cell line was used as an experimental model. Immunoblot and ELISA analysis showed that proteins and enzymes belonging to the cholesterol metabolism network were increased upon NGF treatment in glial cells. Furthermore, NGF significantly increased ApoE secretion and the amount of extracellular cholesterol in the culture medium. Co-culture and U373-conditioned medium experiments demonstrated that NGF treatment efficiently counteracted rotenone-mediated cytotoxicity in N1E-115 neuronal cells. Conversely, neuroprotection mediated by NGF treatment was suppressed when N1E-115 were co-cultured with ApoE-silenced U373 cells. Taken together, these data suggest that NGF controls cholesterol homeostasis in glial cells. More importantly, NGF exerts neuroprotection against oxidative stress, which is likely associated with the induction of glial ApoE secretion.