以风险防控为导向优化电镀企业环境风险应急管理的研究

以风险防控为导向,建立了针对电镀行业的环境风险因子库,共计26项因子。以东莞某电镀园区为例,结合现场调研、因子分析等工作,筛选出九大重点改善因子。采用统计学方法对因子改善前后的结果进行横向及纵向对比,总结出行业普遍存在的薄弱环节,提出有针对性的预防管理对策。     

基于精细化工行业风控评价系统研究

就目前精细化工行业风险存在的问题,针对精细化工行业企业,从金融信贷信息、企业运营信息、行业评价信息、诉讼信息、发展能力等5个维度构建指标评价体系,从而设计了一套完整的服务大数据和人工智能时代的监管信息平台体系。通过搭建模型管理架构,建设监控预警、追踪查证为主的业务应用平台,介绍了可以实现精细化工行业风控评价指标以及即时反馈的风险系统,大大降低精细化工行业的风险系数。     

Association of Dietary Phytosterols with Cardiovascular Disease Biomarkers in Humans

Cardiovascular disease (CVD) is a leading cause of death worldwide. Elevated concentrations of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are major lipid biomarkers that contribute to the risk of CVD. Phytosterols well known for their cholesterol-lowering ability, are non-nutritive compounds that are naturally found in plant-based foods and can be classified into plant sterols and plant stanols. Numerous clinical trials demonstrated that 2 g phytosterols per day have LDL-C lowering efficacy ranges of 8–10%. Some observational studies also showed an inverse association between phytosterols and LDL-C reduction. Beyond the cholesterol-lowering beneficial effects of phytosterols, the association of phytosterols with CVD risk events such as coronary artery disease and premature atherosclerosis in sitosterolemia patients have also been reported. Furthermore, there is an increasing demand to determine the association of circulating phytosterols with vascular health biomarkers such as arterial stiffness biomarkers. Therefore, this review aims to examine the ability of phytosterols for CVD risk prevention by reviewing the current data that looks at the association between dietary phytosterols intake and serum lipid biomarkers, and the impact of circulating phytosterols level on vascular health biomarkers. The clinical studies in which the impact of phytosterols on vascular function is investigated show minor but beneficial phytosterols effects over vascular health. The aforementioned vascular health biomarkers are pulse wave velocity, augmentation index, and arterial blood pressure. The current review will serve to begin to address the research gap that exists between the association of dietary phytosterols with CVD risk biomarkers.     

造纸污泥与市政污泥混合处理可行性研究

以濮阳市龙丰纸业造纸污泥及市辖区3座污水处理厂市政污泥作为研究对象,对造纸污泥和市政污泥的泥质进行了比对分析,对其潜在生态风险进行了评价。结果表明,造纸污泥有机质含量介于市级和县级的市政污泥之间,高于猪厩肥和农用有机肥标准,重金属含量低于市政污泥,且形态稳定,潜在生态风险低,是一种良好的有机肥料资源,可以和市政污泥一起混合处理。     

贵州辣椒中腐霉利和高效氯氟氰菊酯的残留及膳食风险评估

[目的]明确贵州鲜食辣椒中腐霉利和高效氯氟氰菊酯的残留水平及其可能存在的膳食摄人风险.[方法]通过建立一种快速、简便的气相色谱检测鲜食辣椒中腐霉利和高效氯氟氰菊酯残留量的方法,采集贵州各地鲜食辣椒进行残留检测,并对不同人群的膳食暴露及风险进行了评估.[结果]贵州辣椒中腐霉利检出率为8.25％,残留量在0.01～0.62...     

超高效液相色谱-串联质谱法检测花生中18种塑化剂的研究

为了解决塑化剂检测的问题,本文建立了高效液相色谱-串联质谱法检测花生中18种塑化剂。样品经乙腈超声提取并低温低速离心后,直接取上清液置于-18℃冰箱中冷冻至少2 h,上清液过膜后经Shim-pack XR-ODS Ш 反相色谱柱(150 mm×2.0 I.D., 2.0 μm)分离,最后用三重四极杆质谱在多反应监测模式下外标法定量测定。在最佳分析条件下,各塑化剂靶标线性范围均良好,相关系数(r2)均>0.999;检出限和定量限分别在0.0004~1.0000μg/kg和0.0012~3.0000 μg/kg范围内;在3个不同浓度下的加标回收率位于75.26%~114.54%之间,相对标准偏差为1.08%~8.00% (n=6)。该方法操作简单、稳定可靠、检测通量高、检测成本低,有望用于大批量花生样品中塑化剂质量安全风险评估筛查及验证分析,为政府部门粮油质量安全监管提供技术支撑。     

燃气管道泄漏风险评价体系研究

以燃气管道泄漏风险影响因素为出发点,建立包括风险预测层、风险筛查层、风险预警层的燃气管道泄漏风险评价体系。可实现对评价时间段内各风险强度指标进行评分,量化评价风险强度指标。基于风险强度指标评分,计算综合风险得分,对高风险区域进行筛查,量化各风险强度指标的风险强度贡献度。在时序上实现快速迭代,对未来综合风险得分做出预判,以实现风险预警。     

基于模糊数据融合的健康评价方法

研究基于多传感器信号的船舶用柴油机冷却系统的健康状况评价问题, 提出了船舶用柴油机冷却系统健康状况的定量综合评价指标--健康度, 将基于模糊集的数据融合方法用于健康度的计算, 该方法利用层次分析法来确定各个传感器监测参数的重要程度系数, 利用模糊综合评判对多传感器数据进行融合计算得到系统的健康度, 以此为基础, 建立了船舶用柴油机冷却系统的健康评价体系, 给出了系统的健康状况等级. 实验结果表明该方法能够对其健康状况进行定量的、合理的评价.     

OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions

The Novel Organic Cation Transporter, OCTN1, is the first member of the OCTN subfamily; it belongs to the wider Solute Carrier family SLC22, which counts many members including cation and anion organic transporters. The tertiary structure has not been resolved for any cation organic transporter. The functional role of OCNT1 is still not well assessed despite the many functional studies so far conducted. The lack of a definitive identification of OCTN1 function can be attributed to the different experimental systems and methodologies adopted for studying each of the proposed ligands. Apart from the contradictory data, the international scientific community agrees on a role of OCTN1 in protecting cells and tissues from oxidative and/or inflammatory damage. Moreover, the involvement of this transporter in drug interactions and delivery has been well clarified, even though the exact profile of the transported/interacting molecules is still somehow confusing. Therefore, OCTN1 continues to be a hot topic in terms of its functional role and structure. This review focuses on the most recent advances on OCTN1 in terms of functional aspects, physiological roles, substrate specificity, drug interactions, tissue expression, and relationships with pathology.