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11.
Dovile Stravinskiene Aiste Sliziene Lina Baranauskiene Vilma Petrikaite Aurelija Zvirbliene 《International journal of molecular sciences》2020,21(24)
Monoclonal and recombinant antibodies are widely used for the diagnostics and therapy of cancer. They are generated to interact with cell surface proteins which are usually involved in the development and progression of cancer. Carbonic anhydrase XII (CA XII) contributes to the survival of tumors under hypoxic conditions thus is considered a candidate target for antibody-based therapy. In this study, we have generated a novel collection of monoclonal antibodies (MAbs) against the recombinant extracellular domain of CA XII produced in HEK-293 cells. Eighteen out of 24 MAbs were reactive with cellular CA XII on the surface of live kidney and lung cancer cells as determined by flow cytometry. One MAb 14D6 also inhibited the enzymatic activity of recombinant CA XII as measured by the stopped-flow assay. MAb 14D6 showed the migrastatic effect on human lung carcinoma A549 and renal carcinoma A498 cell lines in a ‘wound healing’ assay. It did not reduce the growth of multicellular lung and renal cancer spheroids but reduced the cell viability by the ATP Bioluminescence assay. Epitope mapping revealed the surface-exposed amino acid sequence (35-FGPDGENS-42) close to the catalytic center of CA XII recognized by the MAb 14D6. The variable regions of the heavy and light chains of MAb 14D6 were sequenced and their complementarity-determining regions were defined. The obtained variable sequences were used to generate recombinant antibodies in two formats: single-chain fragment variable (scFv) expressed in E. coli and scFv fused to human IgG1 Fc fragment (scFv-Fc) expressed in Chinese Hamster Ovary (CHO) cells. Both recombinant antibodies maintained the same specificity for CA XII as the parental MAb 14D6. The novel antibodies may represent promising tools for CA XII-related cancer research and immunotherapy. 相似文献
12.
Chemical processes are becoming increasingly complicated, leading to an increase in process variables and more complex relationships among them. The vine copula has a significant advantage in portraying the dependence of high-dimensional variables. However, as the dimensions increase, the vine copula model incurs a high computational load; such pressure greatly reduces model efficiency. Relationships among variables in the industrial process are complex. Different variables may be strongly or weakly associated or even independent. This paper proposes a process monitoring method based on correlation variable classification and vine copula. The weighted correlation measure is first used to divide variables into a correlated subspace and weakly correlated subspace. Then, two vine structures, C-vine and D-vine, are applied to the correlated and weakly correlated subspaces, respectively. This method takes advantage of C-vine for correlated variables and the flexibility of D-vine for weakly correlated variables. Finally, comprehensive statistics are established based on different subspaces. Monitoring results of the numerical system and the Tennessee Eastman process demonstrate the effectiveness and validity of the proposed method. 相似文献
13.
Galin Ivanov Ertugrul Bilgucu Ivelina Ivanova Milena Dimitrova 《International Journal of Dairy Technology》2020,73(3):563-569
The present study aimed to investigate the effect of somatic cell count (SCC) of raw cow's milk on the volatile organic compound (VOC) profiles of yoghurt. Test yoghurt samples were produced from three batches of cow's milk with low, medium and high SCC, respectively. The VOCs were determined by gas chromatography–mass spectrometry (GC–MS) analysis. A lower diacetyl and acetoin content and a higher content of 2‐heptanone, and butanoic and hexanoic acids were established in the yoghurt samples from batches with high SCC of above 1 000 000 cells/cm3. The increased SCC of cow's milk had a negative effect on the volatile organic compound profiles of yoghurt. 相似文献
14.
高浓度聚合物驱提高采收率方法实验研究 总被引:3,自引:0,他引:3
为探索一种新的提高原油采收率的方法,在外形尺寸为4.5 cm×4.5 cm×30 cm、气测渗透率0.9~1.0μm2、变异系数为0.72的二维纵向非均质人造岩心上,模拟大庆油田油藏流体性质及温度条件,研究了高浓度聚合物(HPAM)驱注入时机、聚合物相对分子质量、聚合物段塞体积及段塞组合对驱油效果的影响。通过注入大分子量、高浓度聚合物,结合合理的注入方式,在化学剂成本与三元复合驱相当的情况下,采收率比水驱提高20个百分点以上,接近或超过三元复合驱的水平。实验表明,采用高浓度聚合物驱油是一种较好的提高原油采收率的方法。 相似文献
15.
Zk线性码的对称形式的MacWilliams恒等式 总被引:8,自引:2,他引:6
该文定义了Zk线性码的码字的对称重量计数公式,利用离散的Hadamard变换,建立了线性码与其对偶码之间的对称形式的MacWilliams恒等式. 相似文献
16.
17.
在时变多径衰落信道下,接收到的CDMA信号功率变化较大,此时D-Rake盲自适应多用户检测器性能显著下降,将变步长LMS算法与基于主分量的相干合并引入到D-Rake(DecorrelatingRake)检测器中,构成一种变步长D-Rake,称之为VD-Rake(Variablestep-sizeDecorrelatingRake)检测器。该检测器能克服原D-Rake检测器对信号功率变化较敏感等缺点,有效地改善了D-Rake检测器的性能。 相似文献
18.
提出了用于水利项目方案评价的方法——基于相对最优方案的指标赋权模型,介绍了该方法的基本原理,建立了综合考虑保证出力、年发电量、单位千瓦投资等因素的基于相对最佳方案的指标赋权模型,并用实例加以说明,与模糊优选神经网络模型的评价结果相对比,研究表明该模型适合于水利项目方案的评价和优选。 相似文献
19.
Hannerz Harald; Albertsen Karen; Nielsen Martin Lindhardt; Tüchsen Finn; Burr Hermann 《Canadian Metallurgical Quarterly》2004,23(3):283
This study explored whether factors related to the work environment could predict changes in body mass index (BMI) and whether the effect of psychosocial factors was dependent on baseline BMI. The sample consisted of 1,980 male employees from the Danish National Work Environment Cohort Study. Changes in BMI between 1995 and 2000 were analyzed, by multiple regression, as a function of background variables and a series of occupational variables obtained in 1995. Age, baseline BMI, job insecurity, and psychological demands predicted changes in BMI. Job insecurity and high or low psychological demands increased the likelihood of weight gain among obese employees, whereas they increased the likelihood of weight loss among employees with a low BMI. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
20.
油田注水系统的耗电量一般占整个油田生产耗电的40%-60%,因此降低注水系统的能耗可显著降低油田的生产成本。常规的通过调节阀门开启度来达到调节注水泵出口压力和流量的作法,会使很大一部分能量造成浪费,要解决这个问题,可以采取对注水泵进行调速的方法。文章论述了通过高压变频技术对注水泵进行调速,从而达到节能效果的基本原理;对一台恒速泵和一台变频调速泵并联运行时的效率进行了分析,并对应用实例进行了计算,注水站的效率比原来提高了9.04%,收到了显著的节能效果。 相似文献