Structure-activity studies of human tumour necrosis factors

The mechanism by which tumour necrosis factors (TNF and lymphotoxin,also called TNFß and TNFß respectively) exerttheir cytotoxic activity on many malignant cells, remains largelyunknown. Furthermore, the broad array of differentiation (geneinduction) and mitogenic activities towards many primary cellsis still a subject of intensive investigation. TNF is an importantmediator in inflammation, immune responses and infection-relatedphenomena and these activities contribute to the severe toxidtyseen when TNF is used as an anticancer agent. The first stepin the mechanism of action is the specific binding of the ligandto its receptors and dissection of the molecular mechanism involvedin this interaction is the subject of this review. The reasonsfor the interest in this aspect are obvious: first, the developmentof strong antagonistic TNF analogues can be useful in dampeningthe potentially lethal or debilitating effects of an overproductionof the cytokine (as in septic shock or rheumatoid arthritis).Secondly, since two distinct TNF receptors exist, constructionof TNF muteins that distinguish between both types may leadto derivatives of this plekrtropic agent with a more restrictedbiological activity pattern. Ideally, one would like to developa TNF mutant that has retained its cytotoxic action on tumourcells without inducing the deleterious systemic toxteity. Suchan optimized TNF molecule could become a potent anticancer agent     

Molecular orientation and stress in biaxially deformed polymers. II. Steady potential flow

The development of biaxial segmental orientation and stress in a flexible-chain polymer fluid subjected to steady biaxial extensional flow is analyzed. Closed-formula model based on the Padè approximation of the inverse Langevin function in the non-Gaussian distribution of the chain end-to-end vectors is considered. The approach is free from the limitations related to finite chain extensibility and slow convergence of the series expansion formulations at higher chain deformations.Segmental orientation is characterized by the average orientation tensor, related axial orientation factors and global orientation anisotropy. Orientational behavior and corresponding stresses in the biaxial elongational potential flow are discussed in a wide range of elongation rates. Orientation characteristics calculated for the biaxial flow deformation are much higher than those predicted for the affine biaxial stretch deformation in polymer solids.     

软土地基地下结构的一个CAD软件

本文介绍地下结构计算机辅助设计软件——UCAD的总体结构、主要功能以及解决的问题。     

煤气设施防腐实践及影响质量因素分析

根据近几年三明钢铁公司煤气设施的防腐实践，就影响煤气设施的质量因素进行了分析。     

化工企业环境因素的评价

化工企业环境因素评价是建立环境管理体系的核心任务，化工企业生产过程的特点决定了其环境因素数量多、环境影响大、识别评价难、控制难度大。本文介绍了化工企业环境因素评价的技术方法和过程，可以为提高环境因素评价的科学性、客观性和充分性提供参考。     

Calendar maintenance of arbitrarily structured systems

A semi-Markov model is constructed that describes an arbitrarily structured multicomponent technological system and takes into account its calendar maintenance. Using an aggregation algorithm, approximate values of stationary reliability characteristics and an optimal term of maintenance work are determined for the system. __________ Translated from Kibernetika i Sistemnyi Analiz, No. 2, pp. 69–86, March–April 2006.     

Experimental investigations of the effect of new passive safety systems on the temperature state of fuel elements

Results of experiments conducted on a large-scale integral PSB-VVéR bench and directed toward investigation of the performance of new passive safety systems for nuclear plants with a water-cooled power reactor, an additional system for passive flooding of the active zone, and a system for the passive removal of heat from steam generators are presented. __________ Translated from élektricheskie Stantsii, No. 9, September 2007, pp. 7–10.     

黄河小浪底郑州集中控制系统的实现

黄河小浪底郑州集中控制系统将多个相互联系的不同专业领域子系统有机地连接成一个整体。文中介绍了该系统的硬件配置和主要功能,并简单介绍了该系统所采用的网络安全措施。     

做好闸坝定期巡检确保安全运行

根据国家电力监管委员会《水电站大坝运行安全管理规定》和《混凝土大坝安全监测技术规范》对巡视检查工作的具体要求,结合映秀湾水力发电总厂所辖三座闸坝运行的实际,阐述闸坝安全巡视工作的作用及应重点做好的定期检查及日常巡检工作的内容和要求.     

优化改造油田生产工艺 增产增效提高环保水平——涠洲11-4油田生产工艺优化改造实践

油田生产水处理和海管输油能力不足是制约涠洲11-4油田生产和影响生产安全的瓶颈问题。合理利用油田原有设施和条件,对生产水处理系统和输油管道系统进行工艺优化改造,使该油田B平台海管运行的安全可靠性得以明显提高,并使油田生产水处理能力和处理质量得到有效改善,同时大幅度降低了油田生产成本,拓宽了油田增产挖潜的空间。涠洲11-4油田优化改造生产工艺实践经验,可为进一步拓宽海上老油气田的生产管理思路提供参考。