Three-dimensional investigation and scoring of extracellular matrix remodeling during lung fibrosis using multiphoton microscopy

The organization of collagen during fibrotic processes is poorly characterized because of the lack of appropriate methodologies. Here we show that multimodal multiphoton microscopy provides novel insights into lung fibrosis. We characterize normal and fibrotic pulmonary tissue in the bleomycin model, and show that second-harmonic generation by fibrillar collagen reveals the micrometer-scale three-dimensional spatial distribution of the fibrosis. We find that combined two-photon excited fluorescence and second-harmonic imaging of unstained lung tissue allows separating the inflammatory and fibrotic steps in this pathology, underlining characteristic features of fibroblastic foci in human Idiopathic Pulmonary Fibrosis samples. Finally, we propose phenomenological scores of lung fibrosis and we show that they unambiguously sort out control and treated mice, with a better sensitivity and reproducibility in the subpleural region. These results should be readily generalized to other organs, as an accurate method to assess extracellular matrix remodeling during fibrosis.     

单螺杆压缩机的新进展

针对单螺杆压缩机成本高等的缺点,介绍了在提高其性能、寿命和可靠性的前提下降低成本的途径。     

Combination of multiphoton and reflective confocal imaging of cornea

We combine reflective confocal microscopy with multiphoton microscopy to form a minimally invasive technique to observe the cornea. The two imaging modalities allow detection of complementary information from the cornea. The autofluorescence signal shows the cytoplasm of epithelial cells, and the second harmonic generation signal is used to detect collagen, found mostly in the stroma of the cornea. The reflective confocal imaging allows detection of epithelial cells and keratocytes in the stroma. The system is first tested on bovine cornea. Assessment of the result on the bovine eye will be used to evaluate the potential of the system as a technique for in vivo clinical application.     

基于圆锥滚子的弧面凸轮三维CAD

基于空间机构的共轭啮合原理 ,采用齐次坐标变换法推导了基于圆柱滚子的弧面凸轮的曲面方程与压力角方程 ,并利用UG软件的二次开发模块 ,开发了弧面凸轮三维CAD软件     

基于OpenGL的机械手三维可视化仿真研究

通过对一个机器人机械手三维实时运动仿真系统实例的介绍和分析，阐述了利用OpenGL图形库实现机械手运动仿真的有效方法．重点分析了机械手运动学模型的构建及仿真过程的动态显示，并且讨论了该仿真系统的主要功能模块构成。最后总结了该仿真系统的主要特点，指出了OpenGL在机器人运动仿真中的应用前景。     

基于B/S模式的材料定额管理系统

材料定额计算是CAPP系统的重要组成部分。针对目前企业材料定额的工作量大，重复性强，错误率高等问题，分析了材料定额系统与企业管理信息系统各模块之间的信息流程关系，介绍了基于B／S模式的材料定额管理系统的功能及三层分布式体系结构，重点阐述了材料定额的制订方法、Web环境下材料定额明细报表及汇总报表的实现等关键技术。     

三叶罗茨风机的流量特性研究

摘要：通过对渐开线型三叶罗茨风机的设计参数的分析，计算出了径距比Rm／a与面积利用系数λ、理论流量Qth、实际流量仉及容积效率ηv的相关曲线，并确定了径距比Rm／a的合理选择范围。     

炮膛内高过载环境力测量系统设计

了获取弹丸在膛内高过载情况下的加速度信号,设计了一种弹载数据采集系统。选用高性能的Zynq 7000系列SoC芯片作为控制核心,将采集到的加速度信号通过A/D转换芯片送入大容量Nand Flash存储器完成数据的采集。通过对成品电路板的全面灌封技术,提高了系统整体的抗冲击能力。通过对实测结果进行分析,表明此系统可以准确地获取弹丸的膛内加速度变化曲线。     

彩色三维打印成形技术及应用

介绍了彩色三维打印(3DP)成形技术的工作原理及其成形工艺,分析了彩色三维打印的原型件的物理性能.此外,还介绍了彩色三维打印成形技术的应用.     

三参数灌浆自动记录仪

介绍了研制的LJ型三参数灌浆自动记录仪，仪器运用传感器技术、电子技术与微机技术对灌浆过程中的压力、流量和水灰比3个关键技术参数进行了动态检测，设计了传感器与主机的接口，研制了数据转存器与灌浆资料管理软件。实验结果表明：该仪器具有稳定性好、精度和灵敏度高、响应速度快等特点，在高温、潮湿、高灰尘的恶劣施工现场能正常工作。