亭口水库泥沙研究方法

在多沙河流上修建亭口水库,选用合适的泥沙研究方法,对工程设计至关重要。用泥沙物理模型的试验成果验证泥沙数学模型的计算结果,用数学模型计算在空间与时间上延伸物理模型试验。两者相互补充,能有效地解决水库计算中的泥沙问题。     

基于政府规制的发电市场结构演进及国际实践

通过政府规制下各国发电市场结构演进实践的考察和分析,认为政府利用准入规制控制了发电市场主体进入市场,是政府对发电市场结构进行规制的主要手段,决定着竞争性发电市场结构的形成;政府对市场力的规制可以防止发电商滥用市场力逐利,损害竞争,导致社会福利无谓损失,保护着竞争性发电市场结构形成.结论是政府规制对发电市场结构的演进起着决定性作用.     

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells

Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca²⁺ is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. Ca²⁺ participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of Ca²⁺ through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of Ca²⁺ in both mitochondria and cytoplasm, thereby regulating cellular Ca²⁺ homeostasis. Mitochondrial Ca²⁺ transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis. In particular, MCU and its regulatory proteins represent a new era in the study of MCU-mediated mitochondrial Ca²⁺ homeostasis in tumors. Through an in-depth analysis of the close correlation between mitochondrial Ca²⁺ and energy metabolism, autophagy, and apoptosis of tumor cells, we can provide a valuable reference for further understanding of how mitochondrial Ca²⁺ regulation helps diagnosis and therapy.     

储层流动单元研究新技术在油田开发中的应用

流动单元研究提供了精细解剖砂体,表征砂体内部非均质性的新方法。本文在传统流动单元划分的基础上应用流动带指标新方法(F z)进行储层流动单元的定量划分,为合理进行油田开发动态分析提供依据,同时开辟了一个可预测可操作的有效流动单元研究方法。     

我国量块计量技术概况与发展趋势

该文介绍了我国量块计量技术与国际接轨的进程,并提出了量块计量技术发展需要研究的课题。     

Uncovering Hierarchical Regulation among MYB-bHLH-WD40 Proteins and Manipulating Anthocyanin Pigmentation in Rice

Anthocyanins accumulate in various organs of rice, and the regulatory genes involved in pigmentation of specific organs, such as pericarp, hull, leaf, apiculus, and stigma have been elucidated. However, the corresponding gene for rice culm pigmentation has not been clarified. The well-known MYB-bHLH-WD40 (MBW) complex plays vital role in regulating the anthocyanin biosynthesis pathway in plants. However, the core members of MBW and the hierarchical regulation between these members are not fully elucidated in rice. Here, by map-based cloning, we identified the culm-specific pigmentation gene S1 whose alleles are also known for hull/pericarp pigmentation. We also clarified that one WD40 protein encoding gene, WA1, is indispensable for anthocyanin biosynthesis in rice. In the cascading regulation among MBW members, S1 (bHLH) acts as the master gene by activating the expression of C1 (MYB), and then C1 activates the expression of WA1 (WD40), which is unique in plant species. This enables MBW members to be coordinated in a common way to efficiently regulate anthocyanin biosynthesis genes. Based on these studies, we explored the minimal gene set required for anthocyanin biosynthesis in rice. These findings will help us design new rice varieties with anthocyanin accumulation in specific organs as needed.     

横江水库土坝渗水原因分析及处理措施

横江水库长期处于限制蓄水、 "带病"运行状态.只有对渗水原因进行分析、解决土坝的变形和渗透等问题,才能最终达到除险加固之目的.     

Profile of TREM2-Derived circRNA and mRNA Variants in the Entorhinal Cortex of Alzheimer’s Disease Patients

Genetic variants in TREM2, a microglia-related gene, are well-known risk factors for Alzheimer’s disease (AD). Here, we report that TREM2 originates from circular RNAs (circRNAs), a novel class of non-coding RNAs characterized by a covalent and stable closed-loop structure. First, divergent primers were designed to amplify circRNAs by RT-PCR, which were further assessed by Sanger sequencing. Then, additional primer sets were used to confirm back-splicing junctions. In addition, HMC3 cells were used to assess the microglial expression of circTREM2s. Three candidate circTREM2s were identified in control and AD human entorhinal samples. One of the circRNAs, circTREM2_1, was consistently amplified by all divergent primer sets in control and AD entorhinal cortex samples as well as in HMC3 cells. In AD cases, a moderate negative correlation (r = −0.434) was found between the global average area of Aβ deposits in the entorhinal cortex and circTREM2_1 expression level. In addition, by bioinformatics tools, a total of 16 miRNAs were predicted to join with circTREM2s. Finally, TREM2 mRNA corresponding to four isoforms was profiled by RT-qPCR. TREM2 mRNA levels were found elevated in entorhinal samples of AD patients with low or intermediate ABC scores compared to controls. To sum up, a novel circRNA derived from the TREM2 gene, circTREM2_1, has been identified in the human entorhinal cortex and TREM2 mRNA expression has been detected to increase in AD compared to controls. Unraveling the molecular genetics of the TREM2 gene may help to better know the innate immune response in AD.     

青草沙水库取水泵闸库内侧消能防冲技术研究

通过理论计算与物模试验相结合,对上游取水泵闸库内侧消能防冲技术进行研究,调整库内局部整流措施,以改善出水流态,减小对出水渠及已有建筑物的冲刷,保证取水系统安全。