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51.
教育发展周期比王朝盛衰周期长。在同一教育发展周期内,王朝的衰落带来教育发展的小幅波动,新王朝创立之后能在较短的时间内修复原有的教育结构。而当教育结构自身开始坍塌的时候,王朝的衰落则明显加快这一坍塌的过程。教育结构的重建一般需要几个世纪,这一时期内王朝频繁更替,教育与王朝政治处于两衰的恶性循环中。教育与王朝政治的依存关系形成于春秋战国,巩固于西汉。僵硬的教育结构与人的创造力构成持续的冲突,最终导致教育结构的坍塌。 相似文献
52.
建立了以一维无限深势阱中极端相对论粒子为工质的不可逆量子斯特林热泵循环模型。考虑高低温热源之间的热漏,导出了循环的性能系数与无量纲泵热率的表达式。分析了循环性能与各性能参数之间的关系。研究发现,热泵的性能系数与无量纲泵热率都随粒子在状态1进处于激收态上的占有几度单调递减,性能系数与无量纲泵热率都是势阱宽度比的凸单调函数。无量纲泵热率关于性能系数的关系曲线为回原点的扭叶型,并确定了该不可逆量子斯特林热泵的最优运行区间。 相似文献
53.
Laura Francesca Pisani Gian Eugenio Tontini Carmine Gentile Beatrice Marinoni Isabella Teani Nicoletta Nandi Pasquale Creo Emanuele Asti Luigi Bonavina Maurizio Vecchi Luca Pastorelli 《International journal of molecular sciences》2021,22(11)
Interleukin (IL)-33 is a member of the interleukin (IL)-1 family of cytokines linked to the development of inflammatory conditions and cancer in the gastrointestinal tract. This study is designed to investigate whether IL-33 has a direct effect on human gastric epithelial cells (GES-1), the human gastric adenocarcinoma cell line (AGS), and the gastric carcinoma cell line (NCI-N87) by assessing its role in the regulation of cell proliferation, migration, cell cycle, and apoptosis. Cell cycle regulation was also determined in ex vivo gastric cancer samples obtained during endoscopy and surgical procedures. Cell lines and tissue samples underwent stimulation with rhIL-33. Proliferation was assessed by XTT and CFSE assays, migration by wound healing assay, and apoptosis by caspase 3/7 activity assay and annexin V assay. Cell cycle was analyzed by means of propidium iodine assay, and gene expression regulation was assessed by RT-PCR profiling. We found that IL-33 has an antiproliferative and proapoptotic effect on cancer cell lines, and it can stimulate proliferation and reduce apoptosis in normal epithelial cell lines. These effects were also confirmed by the analysis of cell cycle gene expression, which showed a reduced expression of pro-proliferative genes in cancer cells, particularly in genes involved in G0/G1 and G2/M checkpoints. These results were confirmed by gene expression analysis on bioptic and surgical specimens. The aforementioned results indicate that IL-33 may be involved in cell proliferation in an environment- and cell-type-dependent manner. 相似文献
54.
Chi Nguyen Quynh Ho Minh Thi Tran Chung Chinh Doan Son Nghia Hoang Diem Hong Tran Long Thanh Le 《International journal of molecular sciences》2021,22(9)
Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton organization, which plays an important factor in various cellular processes. The inhibition in cell cycle progression has been considered to be one of the main causes of proliferation inhibition in cells under SMG, but their mechanisms are still not fully understood. This study aimed to evaluate the effects of SMG on the proliferative ability and cytoskeleton changes of Chang Liver Cells (CCL-13). CCL-13 cells were induced SMG by 3D clinostat for 72 h, while the control group were treated in normal gravity at the same time. The results showed that SMG reduced CCL-13 cell proliferation by an increase in the number of CCL-13 cells in G0/G1 phase. This cell cycle phase arrest of CCL-13 cells was due to a downregulation of cell cycle-related proteins, such as cyclin A1 and A2, cyclin D1, and cyclin-dependent kinase 6 (Cdk6). SMG-exposed CCL-13 cells also exhibited a downregulation of α-tubulin 3 and β-actin which induced the cytoskeleton reorganization. These results suggested that the inhibited proliferation of SMG-exposed CCL-13 cells could be associate with the attenuation of major cell cycle regulators and main cytoskeletal proteins. 相似文献
55.
Xihan Fu Shuang Wang Zheng Liu Yaofa Luo Xiaosheng Du Haibo Wang Mi Zhou Xu Cheng Zongliang Du 《大分子材料与工程》2021,306(1):2000504
In recent years, highly efficient oil/water separation materials have brought much attention. It requests superhydrophobic surfaces with a rapid and facile separation process, excellent durability, and large-scale fabrication. Herein, a facile vapor-liquid sol-gel, and free radical polymerization reaction method to prepare the durable and robust superhydrophobic cotton fabric is proposed. Moreover, the fabric can be used for highly efficient and various oil/water separation. It is prepared via a simple two-step process, including a vapor-liquid sol-gel process to deposit with thiols particles, and then followed a free radical polymerization reaction to graft 2,2,3,4,4,4-hexafluorobutyl methacrylate. Scanning electron microscopy and Fourier transform infrared spectrometry prove that the rough structures are generated from the hydrolysis condensation reaction between tetraethyl orthosilicate and 3-mercaptopropyltriethoxysilane. As a result, the synthetic chemical composition provided by the natural fabric and silica nanoparticles synergistically construct a superhydrophobic surface with water contact angles and shedding angle of 158° and 9°, respectively. Additionally, the treated fabric exhibits excellent chemical resistance and self-cleaning ability. Remarkably, the fabric still retains superhydrophobic and excellent mechanical robustness after 30 cycles of various oil/water separation. In summary, the resultant fabrics with excellent chemical resistance, remarkable mechanical robustness, and versatile separation abilities have potential applications in various oil/water separations. 相似文献
56.
研究了快淬工艺对无钴AB5型LaxMm1-x(NiMnSiAlFe)4.9(x=0,0.45,0.75,1.0)合金微观结构及电化学循环稳定性的影响.结果表明快淬处理显著改善合金的成分均匀性,使晶粒细化,并显著提高合金的循环稳定性.当淬速从0m/s增加到28 m/s时,经300次充放循环后,x=0.45合金的容量衰减率D从0.28 mAh/g·c-1(c代表一次循环)下降到0.13mAh/g·c-1;x=1.0合金的容量衰减率D从0.3mAh/g·c-1下降到0.14mAh/g·c-1. 相似文献
57.
Fe替代Co对AB5型贮氢合金循环稳定性的影响 总被引:2,自引:0,他引:2
用铸造及快淬的方法制备了稀土基AB5型Mm(NiMnSiAl)4.3Co0.6-xFex(x=0,0.1,0.2,0.3,0.4,0.5,0.6)贮氢合金,用XRD。TEM及SEM观测了铸态及快淬态的微观结构,测试了合金在铸态及快淬态下的电化学循环稳定性。研究了Fe替代Co对铸态及快淬态贮氢合金微观结构及循环稳定性的影响。研究结果表明,Fe替代Co对铸态及快淬态合金的相结构没有明显影响,但对合金的循环稳定性产生显著影响。Fe替代Co能不同程度地改善铸态及快淬态合金的循环稳定性,但对快淬态合金循环寿命的改善更加显著,导致这一结果的主要原因是Fe替代Co使快淬态合金的微观组织显著细化。 相似文献
58.
Weighting model is the only valuation model of life cycle impact assessment(LCIA) profile now. It simplifies evaluation function into linear function, and makes the determination of weighting factor complicated. Therefore the valuation of LCIA profile is the most critical and controversial step in life cycle assessment(LCA). Development on valuation models, which are understood easily and accepted widely, is urgently needed in the field of LCA.The modeling approaches for the linear evaluation function were summed up. The modeling approaches for the nonlinear evaluation function were set up by function approximation theory, which include choosing preference products, forming preference data, establishing artificial neural network(ANN) and training ANN by preference data.By selecting 7 material products as preference product, experience was done with modeling approaches of the nonlinear evaluation function. The results show that the modeling approaches and valuation model of the nonlinear evaluation function are more practical than the weighting model. 相似文献
59.
High cycle fatigue behaviour of Ti–6Al–4V alloy was studied at 623 K and 723 K. Fatigue strength decreased at elevated temperatures compared with at ambient temperature. In the short life regime, fatigue strength was lower at 723 K than at 623 K, but in the long life regime it was nearly the same at both temperatures. At elevated temperatures, cracks were generated earlier at applied stresses below the fatigue limit at ambient temperature, indicating lowered crack initiation resistance. Small cracks grew faster at elevated temperatures than at ambient temperature, which became more noticeable with increasing temperature. After allowing for the elastic modulus, small cracks still grew faster at elevated temperatures. 相似文献
60.