Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinson’s Disease Model

Layered hydroxide nanoparticles are generally biocompatible, and less toxic than most inorganic nanoparticles, making them an acceptable alternative drug delivery system. Due to growing concern over animal welfare and the expense of in vivo experiments both the public and the government are interested to find alternatives to animal testing. The toxicity potential of zinc aluminum layered hydroxide (ZAL) nanocomposite containing anti-Parkinsonian agent may be determined using a PC 12 cell model. ZAL nanocomposite demonstrated a decreased cytotoxic effect when compared to levodopa on PC12 cells with more than 80% cell viability at 100 μg/mL compared to less than 20% cell viability in a direct levodopa exposure. Neither levodopa-loaded nanocomposite nor the un-intercalated nanocomposite disturbed the cytoskeletal structure of the neurogenic cells at their IC₅₀ concentration. Levodopa metabolite (HVA) released from the nanocomposite demonstrated the slow sustained and controlled release character of layered hydroxide nanoparticles unlike the burst uptake and release system shown with pure levodopa treatment.     

Laboratory and Field Study of the Attraction of Male Pea Midges, Contarinia pisi, to Synthetic Sex Pheromone Components

Behavioral activity of the recently identified sex pheromone components of the pea midge, Contarinia pisi, (2S,11S)-diacetoxytridecane, (2S,12S)-diacetoxytridecane, and 2-acetoxytridecane, was tested in wind tunnel and field-trapping experiments. In the wind tunnel, the attractancy of the three-component blend in a 7 : 10 : 0.1 ratio (following the above order, mimicking the ratios found in gland extract) did not differ significantly from female gland extract, whereas a mixture of the two major components (7 : 10) only attracted 2% of the males to the source. In the field, traps baited with the three-component blend caught by far the largest number of males. Traps baited with the two major components only caught slightly more than the blank traps, and catches in traps baited with 2-acetoxytridecane alone did not differ from catches in the blank traps. Traps baited with the racemate of all three components did not catch more than the blank traps, indicating that some of the enantiomers are inhibitory.     

汽轮机叶片用1Cr12Mo钢成分与热处理工艺对冲击韧度的影响

1Cr12Mo钢属于马氏体不锈钢,被广泛用于汽轮机亚临界机组的低压叶片。该钢在生产过程中由于冶炼方法的不同其化学成分会在一定范围内变化。对大量生产和试验数据进行分析的结果表明,成分的波动和热处理工艺参数的变化对钢的冲击韧度都有重要的影响。     

Urban spatial pattern as self-organizing system: An empirical evaluation of firm location decisions in Cleveland–Akron PMSA,Ohio

Economic models of urban spatial patterns have largely ignored complexity as an attribute of urban systems. Complexity theorists on the other hand have not made sufficiently serious and sustained attempts to verify empirically the relevance of complex systems models for urban spatial patterns. This research bridges this gap by simulating the evolution of an urban employment pattern as a self-organizing complex system and seeking its empirical validation. It estimates the model’s parameters by using firm data aggregated to the level of municipalities in Cleveland-Akron Consolidated Metropolitan Statistical Area in Ohio. The interaction among four parameters, forces of attraction and dispersion and their respective rates of dissipation with distance, are modeled as a two-dimensional complex system. The research compares the states of the modeled system with empirical data to present viable methods for verification, calibration and validation of such models.

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一个国际产、学、研结合的范例--美国伍斯特工学院金属研究所

简要介绍美国伍斯特工学院金属研究所(MPI)在产学研结合方面的成功经验.美国伍斯特工学院是美国历史上第3所工科院校,以重视与企业合作进行工程教育而闻名.MPI是大学研究所与企业的联合体,有包括福特汽车公司、北美压铸协会等131个大大小小的企业及工业协会参加这一联合体.致力于进行针对企业存在的技术问题的基础与应用研究,开发和示范最先进的金属加工技术,为工业合伙人培训雇员等.会员自愿入会,交纳会费,由会员代表组成指导委员会,汇集和整理企业提出的技术需求,每年从中提炼出两个共性的问题,交由MPI进行研究.同时,MPI也同联合体成员共同承担美国政府资助的研究项目,这类项目多数由企业部分出资.研究工作以MPI与企业密切结合的方式开展.联合体每年举办两次会议,由MPI向企业汇报研究结果,交换信息.联合体也以伍斯特工学院为依托,开展企业的人员培训工作.     

2A12铝合金形变热处理工艺在旋压工艺中的应用

采用工艺实验研究2A12铝合金形变热处理工艺中时效温度和室温塑性变形量对材料性能的影响。结果表明:经固溶/淬火+8%室温塑性变形+(140±5)℃,15 h,及空冷人工时效工艺处理后,2A12铝合金获得良好的强塑性配合;在2A12铝合金热挤压管材旋压工艺中采用形变热处理技术,可以使旋压工件材料的综合性能得到明显提高。     

热处理工艺参数对2A12铝合金镍磷镀层性能的影响

研究了2A12铝合金表面镍磷合金镀层的性能及热处理温度对镀层硬度、耐磨性、磨损速率等的影响.     

ZAlSi12Cu2Mg1微弧氧化陶瓷膜层形成过程研究

通过控制微弧氧化时间,研究了ZAlSi12Cu2Mg1在不同氧化时间下膜层的生长过程,分析了氧化过程中正向电流密度、膜层厚度的变化.结果表明微弧氧化阶段又分为氧化过渡阶段和氧化烧结阶段.氧化过渡阶段陶瓷层以向外生长为主;生成Al2O3非晶氧化物;氧化烧结阶段膜层以向内生长为主,此阶段膜层生长速率最快,生成Al2O3晶体和莫来石.氧化烧结阶段对陶瓷膜层的形成起重要作用,对氧化烧结阶段的控制可直接影响膜层的厚度以及膜层中Al2O3晶体含量.     

锂离子电池负极材料Li4Ti5O12的研究进展

"零应变"材料Li4Ti5O12具有优良的循环性能和平稳的放电电压等优点,与石墨电极相比,其安全性和使用寿命都大大提高.本文介绍了锂离子电池负极材料Li4Ti5O12的结构与性能,总结了制备方法、制备工艺参数对其性能的影响,对Li4Ti5O12的掺杂改性作了综述,并对Li4Ti5O12性能提高的发展方向作了展望.     

基于MC9S12DP256的汽车ABS数据采集系统设计

设计了基于MC9S12DP256单片机的汽车ABS数据采集系统;详细介绍了该系统的硬件电路以及系统软件设计.大量的ABS实车实验证明:该数据采集系统工作性能良好,可靠性高.采集数据的精度完全可以满足汽车ABS系统的要求.