Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment

The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified using double solvents in the extraction of analytes. With the modified method, some of the previously undetectable metabolites were recovered and subtle differences in the metabolic changes upon exposure to a single dose of VPA between males and female rats were identified. In male rats, changes in 2-hydroxybutyric acid, pipecolic acid, tetratriacontane and stearic acid were found between the control and treatment groups at various time points from 2.5 h up to 24 h. In contrast, such differences were not observed in female rats, which could be caused by the vast inter-individual variations in metabolite levels within the female group. Based on the measured DBS drug concentrations, clearance and apparent volume of distribution of VPA were estimated and the values were found to be comparable to those estimated previously from full blood drug concentrations. The current study indicated that DBS is a powerful tool to monitor drug levels and metabolic changes in response to drug treatment.     

WT615增压CNG电喷发动机燃烧特性数值分析

以WT615 CNG发动机为模拟研究对象,采用KIVA-3V软件建立了多维软件计算模型,并验证了模型的准确性。在此基础上研究了主要结构参数——燃烧室形状对燃烧特性和整机性能的影响。研究表明,直口形燃烧室的动力性、经济性能最好,更加适用于该天然气发动机,但排放性能有待提高;缩口形燃烧室的整机性能次之,碗形燃烧室的动力性和经济性则较差,后燃现象严重,不适用于天然气发动机。     

天然气色谱工作站的二次开发

利用燃气色谱工作站提供的数据共享接口进行二次编程开发,以拓展工作站的性能。     

电加热方式在SF6开关设备中的应用

由于SF6气体在超低温下产生部分液化,使得SF6开关设备内的SF6气体密度下降,降低了SF6开关设备的开断能力和绝缘水平,无法保证SF6开关设备的可靠运行。为此,本文作者提出了采用电加热装置对SF6开关设备中的SF6气体进行加热,使SF6气体的温度可以始终高于SF6气体液化温度的解决方案。同时,本文对超低温环境下的其他解决方案也进行了分析比较。     

Set up of a Screen-Printing Procedure for the Production of a β Alumina-Based Gas Sensor*

A gas sensor based on a -alumina thick film was recently developed on a laboratory scale. This sensor can be successfully used for selective detection of CO and NO_x, resulting from an appropriate choice of the working temperature of the sensing element. This paper deals with the approach of the industrial transfer of the sensor prototype, mainly concerning the scale-up of the screen-printing procedure from a hand-operated apparatus to an industrial production machine. Many parameters were already investigated during the laboratory development, namely the ink composition in terms of organic/inorganic component ratio, the type and amount of the liquid dispersant and rheological agent, the composition and softening temperature of the binder, the -alumina/binder weight ratio. During the industrial transfer, some other parameters must be considered, such as the particle size distribution of the ceramic components of the ink, the influence of the mesh number of the screen fabric on the surface texture of the -alumina film, the viscosity performances of the ink as a function of the applied shear rate and ageing. A common commercial metallic paste was also used as reference for optimizing the characteristics of the -alumina based ink.     

高炉煤气在热电风联产技术中的应用

高炉煤气作为燃料用于发电和供热，是一种能源综合利用方法。详细论述了以高炉煤气为燃料实现热电风三联供的工艺流程及技术方案，并对其经济效益进行了分析和评价，证明此技术具有很好的社会效益和经济效益。     

相变换热器应用于电站锅炉的探讨

阐述了复合相变换热器是一种新型的换热器,可以控制低温受热面金属不发生低温腐蚀,降低烟气的排放温度,该技术可用于各种燃煤、燃油、燃气锅炉、窑炉、注气炉、加热炉等换热设备,目前复合相变换热器应用于工业锅炉和循环流化床已有不少成功案例[1-3],而应用于大型电站锅炉还很少有报道,结合某330 MW电站锅炉尾部加装复合相变换热器的运行情况,对复合相变换热器应用于电站锅炉的运行情况及优缺点做了简要探讨。     

湿法脱硫GGH结垢原因分析与对策

根据嘉兴发电厂一期2×300MW机组烟气湿法脱硫装置的实际运行情况,分析GGH积灰结垢的原因,提出了相应的对策与控制措施,保障脱硫系统安全、可靠和经济运行。     

烟气预洗涤处理技术在1 000 MW机组无旁路脱硫系统中的应用

通过分析沁北电厂三期工程1 000 MW机组无旁路脱硫系统,论证了湿法脱硫系统采用预洗涤系统的必要性。阐述了预洗涤系统的流程、设计原则、设备选型及实际应用。实践证明,烟气预洗涤系统在控制油污、粉尘和防止高温烟气进入脱硫系统方面效果良好。     

变压器绕组直流电阻超标缺陷的综合判断

针对变压器绕组电阻试验数据超标的情况,在对试验数据进行纵向对比的基础上,结合油色谱分析和红外测温图谱分析,判断出变压器的缺陷部位在高压套管V相柱头处,并分析缺陷产生直流电阻超标的原因,提出缺陷处理措施和整改建议。