从分子结构出发探索 TPP 分子用于生物成像与光学治疗的潜能

5-(4-羧基苯基)-10, 15, 20-三苯基卟啉(TPP)是具有高度对称性和大 π 共轭结构的分子,属于 卟啉衍生物。卟啉是血红素、叶绿素等多种生物成分的关键前体,结构上的特殊性使其呈现出特征的光学特性。该文通过检测不同溶液条件下 TPP 的电子吸收和分子发射光谱的变化,探讨溶液极性、pH 等对其光学性能的影响,测量分子的质子化能力,并与理论计算值互相推演,探究可能出现这些现象的分子结构变化。最后,根据体外溶液和肿瘤细胞中光动力效果预测其在肿瘤的光动力治疗方面 的潜能。     

New Molecular Complex of Fullerene C60 with Porphyrin Dimer [FeTPP]2O: Synthesis and Crystal Structure

Abstract

New molecular complex of C₆₀ with covalently linked (Fe^IIITPP)₂O · C₆₀ dimer has been obtained. The complex has isolated packing of fullerenes in which fullerene molecule is embraced in a pocket built by porphyrins. (Fe^IIITPP)₂O preserves its initial geometry in the complex. The Fe···C(C₆₀) contacts are in the 3.239–3.513 Å range indicating the absence of Fe–C₆₀ coordination. This results in the similarity of the EPR spectra of the complex and parent (Fe^IIITPP)₂O.     

葛根黄酮的壳聚糖颗粒的制备及其释放性研究

以葛根黄酮提取物为芯材,壳聚糖和三聚磷酸钠（TPP）为包裹材料,制备葛根黄酮的壳聚糖颗粒。以包埋率为指标筛选壳聚糖颗粒制备的工艺条件,并通过扫描电子显微镜和X-射线衍射初步分析其性质,同时通过体外药物释放实验评价其释放性能。结果表明：葛根黄酮的壳聚糖颗粒的最佳制备条件为6mg／mL的1mL葛根黄酮溶液,0．6％（m／v）的20mL壳聚糖溶液,0．6％（m／v）的20mL TPP溶液,在此条件下包埋率可达到67．1％。所制备的颗粒的体外释放缓慢且完全,12h时释放率能达到90％,能有效提高葛根黄酮的生物利用率,表明本实验条件下制备的葛根黄酮的壳聚糖颗粒较为成功,达到了预期要求。     

Chitosan—A versatile semi-synthetic polymer in biomedical applications

This review outlines the new developments on chitosan-based bioapplications. Over the last decade, functional biomaterials research has developed new drug delivery systems and improved scaffolds for regenerative medicine that is currently one of the most rapidly growing fields in the life sciences. The aim is to restore or replace damaged body parts or lost organs by transplanting supportive scaffolds with appropriate cells that in combination with biomolecules generate new tissue. This is a highly interdisciplinary field that encompasses polymer synthesis and modification, cell culturing, gene therapy, stem cell research, therapeutic cloning and tissue engineering. In this regard, chitosan, as a biopolymer derived macromolecular compound, has a major involvement. Chitosan is a polyelectrolyte with reactive functional groups, gel-forming capability, high adsorption capacity and biodegradability. In addition, it is innately biocompatible and non-toxic to living tissues as well as having antibacterial, antifungal and antitumor activity. These features highlight the suitability and extensive applications that chitosan has in medicine. Micro/nanoparticles and hydrogels are widely used in the design of chitosan-based therapeuticsystems. The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.     

Effect of Organophosphorous Compounds as Coke Inhibitors on Coking Rate in the Pyrolysis of Naphtha

Abstract

The reduction in the rate of coke formation during naphtha pyrolysis due to the injection of triphenyl phosphine (TPP), tri-o-tolyl phosphine (TTP), and triphenyl phosphine oxide (TPPO) has been investigated in a jet stirred reactor at atmospheric pressure in the temperature range of 800–900°C. Coke formation was significantly reduced in the presence of the additives. The data are consistent with the formation of a metal–phosphorous complex that passivates the metal activity for coke formation. Scanning electron microscope (SEM) and energy dispersive X-ray (EDX) techniques were used for morphological and elemental surface analyses respectively. It was found, that coke formed in presence of organophosphorous inhibitors are softer and have less metal concentrations.     

单层织物湿态热防护性能测试与分析

为研究消防服用织物的湿态热防护性能,以4种适宜用作消防服装多层结构的面料为试样, 通过热辐射和热对流综合热防护性能实验（TPP实验）,测试织物在5种湿状态下热辐射和热对流综合热防护值TPP值和二级烧伤时间,比较不同层面料吸湿后热防护性能的变化。用SPSS软件研究分析了单层织物吸湿后含水率对二级烧伤时间和TPP值的影响。结果显示, 在高强度热流量短时间作用情况下,水分有助于提高单层织物的热防护性能。二级烧伤时间和TPP值均随面料含水率的增大而增大,含水率与二级烧伤时间和TPP值之间存在显著的线性正相关关系。并在TPP值、二级烧伤时间与含水率之间建立了一元线性回归方程。     

5,10,15,20—四苯基卟啉吸附在Ag溶胶和AgCl溶胶表面的UVA谱

讨论了５，１０，１５，２０－四苯基卟啉Ｈ２ＴＰＰ吸附在Ａｇ溶胶和ＡｇＣｌ溶胶上的吸收光谱。谱图显示Ｈ２ＴＰＰ在Ａｇ溶胶和ＡｇＣｌ溶胶表面进行了络合反应，生成其银络合物Ａｇ（Ⅱ）ＴＰＰ。     

磷酸三苯酯对丙烯酸熔融接枝等规聚丙烯的影响

利用磷酸三苯酯(TPP)预溶胀等规聚丙烯(i-PP),而后将单体丙烯酸(AA)及引发剂过氧化异丙苯(DCP)分散于聚丙烯(PP)树脂中,在190℃条件下熔融反应得到接枝产物。利用傅立叶红外光谱分析仪(FT-IR)、熔融流动速率测定仪、差示扫描量热仪(DSC)、热重分析仪(TGA)等对接枝产物的接枝率、熔融流动速率(MFR)、结晶度及热稳定性进行了分析和表征。实验结果表明,当w(TPP)=1%时,较未添加TPP的AA接枝PP,AA接枝率增幅高达130%;TPP的加入可以有效降低副反应的发生;随着接枝率的提高,接枝产物的熔点(Tm)及结晶度(Xc)下降,接枝物的热稳定性有显著提高。     

1000t／a磷酸三苯酯扩产改造

对磷酸三苯酯扩产，生产技术和设备改造做了概述，改造后产品质量指标接近国外标准。     

茶叶的综合利用

详细介绍了茶叶中所含营养成分及其对人体的影响，茶饮料和１７种茶叶保健食品的制作方法，从茶叶中提取茶多酚，儿茶素和咖啡碱的方法及其这些产品的用途，讨论了对云南经济的意义。