体育课的新方法初探

本文通过选项上课,增加了学生的学习兴趣,提高了身体素质和运动竞赛水平。是一种可以借鉴的好方法。     

面向在线率差异的SaaS订阅限额及资源配置组合优化

软件即服务（softuare as a service,SaaS）是一种让用户通过支付订阅费来获得软件访问权的云服务模式。由于其业务的多样性,用户对不同软件的在线访问率存在很大差异,所以不同软件所消耗的云计算资源也存在差异。为避免违反服务等级协议（service level agreement,SLA）而产生违约赔付的风险,SaaS运营商不仅要优化各种软件的计算资源配置,还要对各类软件的订阅量加以限额限制。在考虑SLA限制的基础上,构建了一个以收益最大化为目标的有资源约束的非线性整数规划模型。由于模型计算的复杂性,其无法在多项式时间内求解,所以设计了基于Q学习-粒子群（particle swarm optimizoction,PSO）的融合算法来求解该NP难题。该算法将Q-学习嵌入到PSO中,动态调整PSO参数,从而避免直接使用PSO时会面临的局部最优陷阱和计算效率低下的问题。仿真实验验证了在不同场景下模型及算法的有效性,结果表明该算法可在云计算资源有限的条件下,以较高的求解效率获得收益更高的订阅限额及资源配置方案。其中,当处于需求波动大的情境下时,运营商应尽可能降低软件的资源争用比,通过配置足量的虚拟机资源并设定严格的订阅限额来保障软件的服务质量,减少违约赔付成本;相反,当处于需求波动小的情境下时,运营商可以提高软件的资源争用比,通过放宽订阅限额来抢占更大的市场,实现收益最大化。     

Investigation of a non-explosive directional roof cutting technology for self-formed roadwayOA

Traditional explosives have characteristics of high risk, large vibration, and poor directional fracturing.Consequently, an instantaneous expander with a single crack surface(IESCS), which is a novel nonexplosive directional rock-breaking technique, has been developed. The directional roof-cutting mechanism of the IESCS method, driven by high-pressure gas, was theoretically analyzed. Laboratory experiments and numerical simulations proved the directional slitting effect of the IESCS method to be...     

直流功率变换器的一种控制方法

非线性PID控制方法是一种处理非线性控制问题的简单而直接的办法。本文将这一方法应用于脉宽调制变换器的非线性无穷大频率平均模型,重点研究了升降压式变换器,通过数字仿真分析,说明了变换器非线性PID控制器的调节性能,从而表明非线性PID控制器应用于开关式直流功率变换器的控制的可行性。     

120 kt/a硫磺制酸水管锅炉改造为火管锅炉的技术总结

介绍FRS-12S-14.5/3.82-450型余热水管锅炉以较少的投资、较少的工程量、较短的施工周期改造成QF35/1050-14.2-3.82/450型火管锅炉,使热力系统满足了120kt/a硫磺制酸装置的工艺要求。改造后系统运行平稳,运行率提高,维护费用减少,生产成本降低,解决了水管锅炉因换热管束爆管导致锅炉腐蚀及烟气泄漏造成的环境污染等问题。     

轴流涡轮与排气壳扩压段一维耦合设计研究

为探究轴流涡轮耦合排气壳扩压段的一维设计变量选取规律,提高排气壳扩压段的性能,参考现有NRCC叶栅导叶模型,采用自编程序,结合理论分析构建轴流涡轮与排气扩压段耦合的一维设计模型。详细分析耦合设计中影响扩压段的静压恢复系数以及总体性能的因素。研究结果表明：扩压段面积比、平均倾角、扩张角以及壁面摩擦系数等设计参数不仅影响扩压段的静压恢复系数,也影响涡轮的气动效率;本研究模型在面积比为3.5、平均倾角为30°、扩张角δ为5°时整体性能最优;涡轮出口气流的马赫数、叶顶泄漏流以及出口旋流对扩压段的性能有很大影响,出口半径比的增大会使得静压恢复系数降低,因此在耦合设计时应充分考虑涡轮以上参数的选择。     

Transport properties of 1,1,1,2-tetrafluoroethane (R134a)

New equations for the thermal conductivity and the viscosity of R134a that are valid in a wide range of pressures and temperatures are presented. They were obtained through a theoretically based, critical evaluation of the available experimental data, which showed considerable inconsistencies between data sets, in particular in the vapor phase. In the critical region the observed enhancement in the thermal conductivity is well represented by a crossover model for the transport properties of fluids. Since thermodynamic properties enter into the calculation of the critical enhancement of the transport properties, a new fundamental equation for the critical region was developed also.Paper dedicated to Professor Joseph Kestin.     

ZY6400型液压支架多通块的改型设计

针对多通块原设计中的整体式结构所带来的工艺复杂,产品合格率低,制造成本高等弊端,将其改型为用螺栓联接上下2片的分体式结构,收到了良好的效益。     

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Lung cancer is the leading cause of cancer death worldwide. miR-199a, which has two mature molecules: miR-199a-3p and miR-199a-5p, plays an important biological role in the genesis and development of tumors. We collected recent research results on lung cancer and miR-199a from Google Scholar and PubMed databases. The biological functions of miR-199a in lung cancer are reviewed in detail, and its potential roles in lung cancer diagnosis and treatment are discussed. With miR-199a as the core point and a divergence outward, the interplay between miR-199a and other ncRNAs is reviewed, and a regulatory network covering various cancers is depicted, which can help us to better understand the mechanism of cancer occurrence and provide a means for developing novel therapeutic strategies. In addition, the current methods of diagnosis and treatment of lung cancer are reviewed. Finally, a conclusion was drawn: miR-199a inhibits the development of lung cancer, especially by inhibiting the proliferation, infiltration, and migration of lung cancer cells, inhibiting tumor angiogenesis, increasing the apoptosis of lung cancer cells, and affecting the drug resistance of lung cancer cells. This review aims to provide new insights into lung cancer therapy and prevention.     

The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype

Nicotine exposure either from maternal cigarette smoking or e-cigarette vaping is one of the most common risk factors for neurodevelopmental disease in offspring. Previous studies revealed that perinatal nicotine exposure programs a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE) in postnatal life, yet the underlying mechanisms remain undetermined. The goal of the present study was to determine the regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps. All experiments were conducted in offspring pups at postnatal day 9 (P9). Perinatal nicotine exposure significantly enhanced expression of miR-181a but attenuated autophagy-related protein 5 (ATG5) mRNA and protein levels in neonatal brains. Of interest, miR-181a mimicking administration in the absence of nicotine exposure also produced dose-dependent increased hypoxia/ischemia (H/I)-induced brain injury associated with a decreased ATG5 expression, closely resembling perinatal nicotine exposure-mediated effects. Locked nucleic acid (LNA)-miR-181a antisense reversed perinatal nicotine-mediated increase in H/I-induced brain injury and normalized aberrant ATG5 expression. In addition, nicotine exposure attenuated a long non-coding RNA (lncRNA) H19 expression level. Knockdown of H19 via siRNA increased the miR-181a level and enhanced H/I-induced neonatal brain injury. In conclusion, the present findings provide a novel mechanism that aberrant alteration of the H19/miR-181a/AGT5 axis plays a vital role in perinatal nicotine exposure-mediated ischemia-sensitive phenotype in offspring and suggests promising molecular targets for intervention and rescuing nicotine-induced adverse programming effects in offspring.